Polymorphisms in the LPL gene and their association with growth traits in Jiaxian cattle

Abstract

ABSTRACT. Previous studies showed that the lipoprotein lipase (LPL) gene was involved in metabolism and transport of lipids, suggesting that the LPL is a potential candidate gene affecting growth traits in animals. The aim of this study was to identify polymorphism in the bovine LPL gene and analyze its possible association with growth traits in 218 randomly selected Jiaxian cattle. We used DNA sequencing to identify single nucleotide polymorphisms (SNPs) in the LPL gene. A sequence analysis revealed three SNPs: two in intron 5 (C18306T and C18341T) and one in exon 6 (G18362A). G18362A is a missense mutation leading to a change of the 325th glycine to serine. Based on c 2 tests, the genotypic distributions of C18306T were in agreement with the Hardy-Weinberg equilibrium (P > 0.05), whereas the other two mutations were not (0.05 > P > 0.01). Association analyses showed that the C18341T SNP was significantly associated with several growth traits (P < 0.01 or P < 0.05), and the G18362A was associated with withers height (P < 0.05). Our results suggest that LPL gene variation may be considered molecular markers for growth traits in Jiaxian cattle.

Genetic variants in the serum amyloid A2 (SAA2) gene as a potential marker for milk production traits in Chinese Holstein cows

“…Milk performance is considered to be primary economic trait in dairy cattle, which is regulated by a series of factors, such as inheritance, age, diet, location and other random environment factors. Accumulating genome‐wide association studies (GWAS) indicated that a numbers of candidate genes (i.e., Toll‐like receptor 4, UDP‐glucose dehydrogenase, complement component 4) are involved in complex mechanisms, thereby altering milk performance traits (Gui et al., 2016; Li et al., 2015; Palombo et al., 2018), Here, we detected significant SNPs within the SAA2 gene that potentially influence milk composition and yield in Chinese dairy cattle, which could be used as a genetic marker aiming towards long‐term improvement in production.…”

“…The intronic g.18341 C>T of the lipoprotein lipase ( LPL ) gene was significantly correlated with withers height and chest depth in Nanyang cattle (Gui et al., 2016). Currently, it was speculated that 14061A>G and g.3208C>T may impact the biological function, resulting in an alteration in phenotype of mammal.…”

Association between Single Nucleotide Polymorphisms in SIRT1 and SIRT2 Loci and Growth in Tibetan Sheep

“…Previously, the g.2694 C > T and g.3801 T > C mapping on intronic SNPs of max dimerization protein 3 (MXD3) influenced on several growth traits in two Chinese indigenous beef cattle [23]. The intronic g.18341 C > T of the lipoprotein lipase (LPL) was significantly correlated with withers height and chest depth in Nanyang cattle [24].…”