Polymorphisms in the <i>interleukin‐1 </i>gene influence the stratum corneum interleukin‐1α concentration in uninvolved skin of patients with chronic irritant contact dermatitis

Jongh, Cindy M. de; Khrenova, Liubov; Kežić, Sanja; Rustemeyer, Thomas; Verberk, Maarten M.; John, Swen Malte

doi:10.1111/j.1600-0536.2007.01316.x

Cited by 41 publications

(24 citation statements)

References 30 publications

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“…Following the addition of test compounds, the TNF- α levels were lower than that seen for the untreated irradiated cells. When IL-1 α (10 ng/mL) was added to the UVB-irradiated melanocyte cultures, there was an increase in TNF- α release (120-fold; Figure 3(a), Table 1) similar to that seen in cultured keratinocytes (results not shown) and previous studies [38–40]. When the IL-1 α stimulated melanocyte cells were treated with α -tocopherol, CO 2 -SFE mussel oil, and 5 β -scymnol, the levels of TNF- α shed from the cells fell by 53%, 65%, and 76%, respectively (Figure 3(a), Table 1).…”

Section: Resultssupporting

confidence: 81%

Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-αRelease from UVB-Irradiated Human Melanocyte-Derived Cells

Muthusamy

Hodges

Macrides

et al. 2011

Oxidative Medicine and Cellular Longevity

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UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma. Natural products like 5β-scymnol and CO2-supercritical fluid extract (CO2-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiation. Therefore, their effect on the release of the proinflammatory cytokine, tumour necrosis factor-α (TNF-α), from UVB-irradiated human melanocytic cells was examined. Human epidermal melanocytes (HEM) and MM96L melanoma cells were exposed to UVB radiation and IL-1α. Cell viability and TNF-α levels were determined 24 hours after-irradiation while p38 mitogen-activated protein kinase (MAPK) activation was observed at 15 min after-irradiation. When α-tocopherol, CO2-SFE mussel oil, and 5β-scymnol were added to the UVB-irradiated HEM cells treated with IL-1α, TNF-α levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells. This effect was not due to inhibition of the intracellular p38 MAPK signalling pathway. These compounds may be useful in preventing inflammation-induced damage to normal melanocytes.

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Section: Resultssupporting

confidence: 81%

Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-αRelease from UVB-Irradiated Human Melanocyte-Derived Cells

Muthusamy

Hodges

Macrides

et al. 2011

Oxidative Medicine and Cellular Longevity

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“…A strong association was recently identified between AD and mutations in the FLG (6,7), whereas a moderate association was found with genetic variations in the claudin 1 gene (encoding epidermal tight junctions) in mainly African Americans (8), supporting the notion that skin inflammation is often secondary to skin barrier abnormality (9). Although genetic risk factors for hand eczema and contact sensitization are not yet well-characterized, and are expected to play a more modest role for the pathogenesis, they include FLG mutations and polymorphisms in detoxification systems and immunological pathways (4,(10)(11)(12). Whether xerotic skin increases the risk of hand eczema and contact sensitization has been little-investigated, whereas the association between AD and xerosis is wellestablished.…”

mentioning

confidence: 90%

Xerosis is Associated with Atopic Dermatitis, Hand Eczema and Contact Sensitization Independent of Filaggrin Gene Mutations

Thyssen

Johansen²,

Zachariae³

et al. 2013

Acta Derm Venerol

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Atopic dermatitis, hand eczema and contact sensitization are prevalent disorders, and may, in many cases, be secondary to skin barrier abnormality. The aim of this study was to investigate the association between self-reported generalized xerosis, atopic dermatitis, hand eczema and contact sensitization, taking filaggrin gene mutations into account. Questionnaire data were collected from a cross-sectional study performed in a general population in Copenhagen. A total of 3,460 18-69-year-olds were patch-tested and 3,335 were genotyped for the 2282del4 and R501X mutations in the filaggrin gene. Atopic dermatitis and hand eczema were significantly associated with generalized xerosis, whereas contact sensitization (not nickel) showed only a borderline significant association. These results suggest that generalized xerosis may increase the risk of common skin disorders.

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“…Accordingly, the same research group reported that carriers of a variant IL1A-889T allele have a reduced amount of IL-1α in their stratum corneum 21) . It might be speculated that an intrinsic favourable cytokine balance reflected in a high IL-1RA /IL-1α ratio due to the reduced amount of IL-1α might result in a better resistance against skin irritants.…”

Section: Genetic Factors and Icdmentioning

confidence: 99%

Individual Susceptibility to Occupational Contact Dermatitis

2009

Self Cite

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Occupational Contact Dermatitis (OCD) is one of the most common work-related diseases. High risk occupations are in health care, hairdressing, food sector and metal industry. OCD tends to become chronic; persistent OCD often results in impaired quality of life and loss of work ability. The purpose of this article is to review the present knowledge on the factors which determine individual susceptibility to acquire OCD. Recent discoveries regarding genes involved in the skin barrier, inflammatory response and biotransformation of xenobiotics provide more insight in the individual susceptibility for OCD. Knowledge of the factors which predispose to OCD is useful in occupational health practice for the application of preventive measures and for career guidance for apprentices and workers in high risk occupations.

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Polymorphisms in the interleukin‐1 gene influence the stratum corneum interleukin‐1α concentration in uninvolved skin of patients with chronic irritant contact dermatitis

Abstract: We have shown a clear effect of IL1 genotype on protein expression in the SC. This altered expression may be responsible for the interindividual differences in the inflammatory response of the skin.

Cited by 41 publications

References 30 publications

Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-αRelease from UVB-Irradiated Human Melanocyte-Derived Cells

Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-αRelease from UVB-Irradiated Human Melanocyte-Derived Cells

Xerosis is Associated with Atopic Dermatitis, Hand Eczema and Contact Sensitization Independent of Filaggrin Gene Mutations

Individual Susceptibility to Occupational Contact Dermatitis

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