Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers

Ryk, Charlotta; Kumar, Rajiv; Thirumaran, Ranjit K.; Hou, Sai‐Mei

doi:10.1016/j.lungcan.2006.08.004

Cited by 83 publications

(46 citation statements)

References 39 publications

(58 reference statements)

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“…Publications on NBS1 polymorphisms have mainly focused on rs1805794 and the risk of cancers including lung, breast, bladder, renal cell cancers, non-Hodgkin lymphoma and childhood acute leukemia (Medina et al, 2003;Lan et al, 2005;Zienolddiny, 2005;Landi et al, 2006;Ryk et al, 2006;Hsu et al, 2007;Choudhury et al, 2008;Margulis et al, 2008;Mosor et al, 2008;Schuetz et al, 2009;Stern et al, 2009;Park et al, 2010), but the results were not consistent. A recent meta-analysis on rs1805794 has shed light on a positive association between the variant genotype of rs1805794 and the risk of multiple cancers (MeiXia et al, 2009).…”

Section: 851 Variants Of Nbs1 Predict Clinical Outcome Of Chemotheramentioning

confidence: 99%

Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

Hu²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: 851 Variants Of Nbs1 Predict Clinical Outcome Of Chemotheramentioning

confidence: 99%

Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

Hu²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The variant T allele has been reported to be associated with a nonstatistically significant increased risk of squamous cell carcinoma of head and neck 37 and with a reduced risk of leukaemia, 17 whereas no association has been found in meningiomas, 38 and gastric cancer. [39][40][41] Moreover, conflicting results have been published on the associations with breast cancer, 16,21,22 lung cancer, 17,19,42 malignant melanoma 20,43,44 and bladder cancer. 17,18,45 It was also noted that the frequency of the XRCC3-241Met allele in our control group (5.9%) was similar to that previously reported in a Chinese population, 39 but quite different from that found in Caucasians and African Americans, suggesting that the Met allele frequency could vary by ethnicity.…”

Section: Discussionmentioning

confidence: 99%

XRCC3 haplotypes and risk of gliomas in a Chinese population: A hospital‐based case‐control study

Zhou

Liu

Zhang

et al. 2009

Intl Journal of Cancer

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In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype-based approach to investigate whether 4 tagging single nucleotide polymorphisms of the XRCC3 gene are associated with risk of gliomas in 771 glioma patients and 752 cancerfree controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the unconditional logistic regression, and haplotype associations were estimated using Haplo.Stat. After adjustment for age and sex, the variant G allele of rs861530 and T allele of rs3212092 were significantly associated with an increased risk of gliomas (AG/GG versus AA: adjusted OR 5 1.44, 95% CI 5 1.15-1.80, p 5 0.001 and CT/TT versus CC: adjusted OR 5 1.66, 95% CI 5 1.12-2.46, p 5 0.013, respectively). Consistent with these results, XRCC3 haplotype ''GGCC'' containing rs861530 G allele and haplotype ''AGTC'' containing rs3212092 T allele were also significantly associated with an elevated risk of gliomas compared with the common haplotype ''AGCC'' (adjusted OR 5 1.35, 95% CI 5 1.14-1.58, p 5 0.000 and adjusted OR 5 1.67, 95% CI 5 1.11-2.52, p 5 0.015, respectively). Our results suggest that common genetic variants in the XRCC3 gene may modulate glioma risk. ' 2009 UICC

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“…All polymorphisms have been reported to affect either the expression or function of their host genes or to be associated with the risk of malignancy (26)(27)(28)(29)(30)(31)(32)(33)(34). These SNPs consisted of six nonsynonymous SNPs (nsSNPs) with an amino acid substitution (ATM D1853N, NBS1 E185Q, BRCA2 N372H, XRCC3 T241M, RAG1 K820R, and LIG4 T91I), one intronic SNP (XRCC3 A17893G), a splicing site SNP (XRCC4 IV7-1), one SNP in the 3' untranslated region (UTR) of KU80 gene, and one SNP in the 3' region of XRCC2.…”

Section: Selection Of Dsb Polymorphisms and Genotypingmentioning

confidence: 99%

Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions

Yang

Lippman

Huang

et al. 2008

European Journal of Cancer

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Oral premalignant lesions (OPLs) are early genetic events en route to oral cancer. To identify individuals susceptible to OPL is critical to the prevention of oral cancer. In a case-control study consisting of 147 patients with histologically confirmed OPL and 147 matched controls, we evaluated the associations of 10 genetic variants in nine genes of the double-strand break (DSB) DNA repair pathway with OPL risk. The most notable finding was an intronic polymorphism (A17893G) of the XRCC3 gene. Compared with the homozygous wild-type AA genotype, the odds ratios [OR] (95% confidence interval [CI]) for the heterozygous AG and homozygous variant GG genotype were 0.85 (0.49-1.48) and 0.18 (0.07-0.47), respectively (P for trend=0.002). In addition, compared with the most common A-C haplotype of XRCC3 (in the order of A17893G-T241M), the G-C haplotype was associated with a significantly decreased risk of OPL (OR=0.40, 95% CI 0.23-0.68). Moreover, compared with individuals without the G-C haplotype, the ORs were 1.04 (0.56-1.95) and 0.20 (0.08-0.51) for subjects with one copy and two copies of the G-C haplotype, respectively (P for trend=0.005). Classification and regression tree (CART) analysis further revealed potential highorder gene-gene and gene-environmental interactions and categorized subjects into different risk groups according to their specific polymorphic signatures. Overall, our study provides the first epidemiological evidence supporting a connection between DSB gene variants and OPL development. Our data also suggest that the effects of high-order interactions should be taken into consideration when evaluating OPL predisposition.

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Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers

Cited by 83 publications

References 39 publications

Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

XRCC3 haplotypes and risk of gliomas in a Chinese population: A hospital‐based case‐control study

Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions

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