XRCC3 haplotypes and risk of gliomas in a Chinese population: A hospital‐based case‐control study

Abstract

In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype-based approach to investigate whether 4 tagging single nucleotide polymorphisms of the XRCC3 gene are associated with risk of gliomas in 771 glioma patients and 752 cancerfree controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the unconditional logistic regression, and haplotype associations were estimated using Haplo.Stat. After adjustment for age and sex, the variant G allele of rs861530 and T allele of rs3212092 were significantly associated with an increased risk of gliomas (AG/GG versus AA: adjusted OR 5 1.44, 95% CI 5 1.15-1.80, p 5 0.001 and CT/TT versus CC: adjusted OR 5 1.66, 95% CI 5 1.12-2.46, p 5 0.013, respectively). Consistent with these results, XRCC3 haplotype ''GGCC'' containing rs861530 G allele and haplotype ''AGTC'' containing rs3212092 T allele were also significantly associated with an elevated risk of gliomas compared with the common haplotype ''AGCC'' (adjusted OR 5 1.35, 95% CI 5 1.14-1.58, p 5 0.000 and adjusted OR 5 1.67, 95% CI 5 1.11-2.52, p 5 0.015, respectively). Our results suggest that common genetic variants in the XRCC3 gene may modulate glioma risk. ' 2009 UICC

Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis

“…Of these articles, two was excluded because on (Goode et al, 2002) is a review and the other is a repeated article (Zhou et al, 2009). At last, a total of nine studies were included in this meta-analysis (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Custodio et al, 2012;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013), all of these publications were written in English. The study characteristics of the included in the meta-analysis were presented in Table 1.…”

Molecular Epidemiology of Primary Brain Tumors

“…We have listed about 20 epidemiological studies reporting positive associations between DNA repair polymorphisms and cancer risk (Table 1 [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] ). Only a small proportion of studies were large (five studies were more than 500 pair cases and controls) and population based; however, some consistencies in results are apparent.…”

The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis

“…According to the inclusion and exclusion criteria, a total of nine publications with 3,752 Cases and 4,849 Controls were included in this meta-analysis (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Custódio et al, 2012;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013). Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations.…”

“…Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations. Five of the studies (Wang et al, 2004;Zhou et al, 2009;Rajaraman et al, 2010;Liu et al, 2012;Luo et al, 2013) were hospital-based and four (Kiuru et al, 2008;Liu et al, 2009;Custódio et al, 2012;Pan et al, 2013) were population-based. The genotype distributions in the controls were conformed to the HWE in all studies.…”