Polymorphisms in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction

Iacoviello, Licia; Castelnuovo, Augusto Di; Knijff, Peter de; D’Orazio, Andria; Amore, C.; Arboretti, Rosa; Kluft, C.; Donati, Maria Benedetta

doi:10.1056/nejm199801083380202

Cited by 268 publications

(182 citation statements)

References 23 publications

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“…Plasma CRP level, which is also a CV risk factor (Ridker, 1997), did not change either with diet or wine intervention. Plasma levels of ®brinogen and, probably those of factors VIIc and VIIIc, have direct association with CV disease (Ridker, 1997;Mead et al, 1986;Held et al, 2000;Rumley et al, 1999;Iacoviello et al, 1998;Redondo et al, 1999). It has been hypothesized that differences in diet and wine intake could partially explain the lower CV morbidity and mortality in southern European countries in comparison with their northern counterparts.…”

Section: Discussionmentioning

confidence: 99%

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

et al. 2001

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Objectives:To compare the effect of alcohol-free Mediterranean-type diet (MD) and high-fat diet (HFD) on plasma concentration of emergent haemostatic cardiovascular risk factors (HCVRF). Also, to test if red wine supplementation modi®es HCVRF, independent of diet. Design, subjects and intervention: Controlled prospective intervention study. Two groups, each of 21 healthy male university students (22 AE 3.4 y), received either MD or HFD for 90 days. Between days 30 and 60, both diets were supplemented with 240 mladay of red wine. Baseline and T30, T60 and T90-day samples were drawn. No drop out from the study was observed. Setting: University campus and outpatient nutrition clinic. Results: Volunteers on HFD at T30 had increases in pro-coagulants ®brinogen (22%), factor VIIc (9%), and factor VIIIc (4%), and decreases in natural anticoagulants antithrombin III (3%), protein C (11%) and protein S (6%) and of 20% in plasminogen activator inhibitor-1. At the same time, individuals on MD had increases in ®brinogen (4%), antithrombin III (5%), protein C (3%), protein S (2.7%), and decreases in factor VIIIc (9%), and plasminogen activator inhibitor-1 (21%). After adjusting by baseline values, MD was associated with lower plasma ®brinogen (P 0.03), factor VIIc (P 0.034) and factor VIIIc (P 0.0057) and with higher levels of protein S (P 0.013). Red wine supplementation, in both diets, resulted in decreased plasma ®brinogen (P 0.001) and factor VIIc (P 0.05), and increased tissue plasminogen activator antigen (P 0.01) and plasminogen activator inhibitor-1 antigen (P 0.0003). Wine consumption was also associated with signi®cantly (P 0.01) divergent effects on antithrombin III: it decreased by 10% in individuals on HFD but increased slightly in those on MD. No effects of diet or wine were detected in plasma protein C and C-reactive protein.Conclusion: MD and moderate consumption of red wine have complementary, mostly bene®cial effects on HCVRF.

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Section: Discussionmentioning

confidence: 99%

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

et al. 2001

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“…77,78 Similar to fibrinogen, the latter is a known determinant of hypercoagulability and of the risk of CVD. 21,23,79 Whether a similar gradient for fibrinogen is also present also is unclear.…”

Section: Areas Of Future Researchmentioning

confidence: 99%

Measuring Plasma Fibrinogen to Predict Stroke and Myocardial Infarction

Maresca

Blasio

Marchioli

et al. 1999

ATVB

296

182

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Abstract-Plasma fibrinogen is a major determinant of platelet aggregation and blood viscosity. The decrease in plasma fibrinogen by bezafibrate is associated with a decrease in the risk of reinfarctions. To strengthen the predictive value of plasma fibrinogen with respect to cardiovascular risk, we performed a meta-analysis of studies conducted between 1984 and 1998. Emphasis has been put on the relationship between high levels of plasma fibrinogen and fatal and/or nonfatal cardiovascular events in both the general population and in patients with previous cardiovascular events. Twenty-two studies (13 prospective, 5 cross-sectional, and 4 case-control) addressing the association between fibrinogen plasma concentrations and cardiovascular disease were analyzed. The overall estimate of risk of cardiovascular event in subjects with plasma fibrinogen levels in the higher tertile, was twice as high as that of subjects in the lower one (odds ratio, 1.99; 95% confidence interval, 1.85 to 2.13). High plasma fibrinogen levels were associated with an increased risk of cardiovascular disease in healthy as much as in high-risk individuals. A metaregression showed no confounding effects attributable to selected characteristics of retrieved studies. A subgroup analysis (study design, follow up, mean fibrinogen levels, percentage of smokers, and mean age) allowed us to conclude that fibrinogen is an independent risk factor for cardiovascular disease; that it interacts with major determinants of myocardial and cerebrovascular ischemia; and that, in secondary prevention studies, it enhances by 8% the prediction of future events by established risk factors. Thus, fibrinogen measurements should be encouraged to refine the overall risk profiles of individuals and to better tailor preventive interventions.

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“…In summary, we found that about 40% of Italians carry B-MYB polymorphisms that confer a significant (Iacoviello et al, 1998). The remaining 130 control DNAs were gathered in different Italian hospitals from over 65 years noncancer patients.…”

Section: Functional Characterization Of B-myb Polymorphisms R Schwab mentioning

confidence: 89%

Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk

Schwab¹,

Bussolari

Corvetta

et al. 2007

Oncogene

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The B-MYB proto-oncogene is a transcription factor belonging to the MYB family that is frequently overexpressed or amplified in different types of human malignancies. While it is suspected that B-MYB plays a role in human cancer, there is still no direct evidence of its causative role. Looking for mutations of the B-MYB gene in human cell lines and primary cancer samples, we frequently isolated two nonsynonymous B-MYB polymorphic variants (rs2070235 and rs11556379). Compared to the wild-type protein, the B-MYB isoforms display altered conformation, impaired regulation of target genes and decreased antiapoptotic activity, suggesting that they are hypomorphic variants of the major allele. Importantly, the B-MYB polymorphisms are common; rs2070235 and rs11556379 are found, depending on the ethnic background, in 10-50% of human subjects. We postulated that, if B-MYB activity is important for transformation, the presence of common, hypomorphic variants might modify cancer risk. Indeed, the B-MYB polymorphisms are underrepresented in 419 cancer patients compared to 230 controls (odds ratio 0.53; (95%) confidence interval 0.385-0.755; P ¼ 0.001). This data imply that a large fraction of the human population is carrier of B-MYB alleles that might be associated with a reduced risk of developing neoplastic disease.

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Polymorphisms in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction

Abstract: Our findings suggest that certain polymorphisms of the factor VII gene may influence the risk of myocardial infarction. It is possible that this effect may be mediated by alterations in factor VII levels.

Cited by 268 publications

References 23 publications

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

Measuring Plasma Fibrinogen to Predict Stroke and Myocardial Infarction

Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk

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