Polymorphisms in the angiotensin I converting enzyme (ACE) gene are associated with multiple sclerosis risk and response to Interferon-β treatment

Yaeghmaie, Rana; Ghafouri‐Fard, Soudeh; Noroozi, Rezvan; Tavakoli, Fatemeh; Taheri, Mohammad; Ayatollahi, Seyed Abdulmajid

doi:10.1016/j.intimp.2018.09.014

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Interestingly, we have analyzed the well-studied I/D in ACE in Iranian patients with multiple sclerosis and reported association between this polymorphism and response to Interferon-β treatment [71]. Thus, ACE/ ACE2 polymorphisms not only can predispose individuals to diverse diseases, but also they can modulate response of patients to therapeutic options.…”

Section: Vascular Pharmacology 130 (2020) 106680mentioning

confidence: 99%

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

Ghafouri‐Fard

Noroozi

Omrani

et al. 2020

Vascular Pharmacology

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Angiotensin-converting enzyme (ACE) and its homologue, ACE2, have been mostly associated with hypertensive disorder. However, recent pandemia of SARS-CoV-2 has put these proteins at the center of attention, as this virus has been shown to exploit ACE2 protein to enter cells. Clear difference in the response of affected patients to this virus has urged researchers to find the molecular basis and pathophysiology of the cell response to this virus. Different levels of expression and function of ACE proteins, underlying disorders, consumption of certain medications and the existence of certain genomic variants within ACE genes are possible explanations for the observed difference in the response of individuals to the SARS-CoV-2 infection. In the current review, we discuss the putative mechanisms for this observation.

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Section: Vascular Pharmacology 130 (2020) 106680mentioning

confidence: 99%

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

Ghafouri‐Fard

Noroozi

Omrani

et al. 2020

Vascular Pharmacology

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“…PCR was used to examine the I\D polymorphism in the ACE gene's 16th intron. Primers were used to perform the PCR(Akbari et al, 2022;Yaeghmaie et al, 2018).…”

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confidence: 99%

Cancer patients with Angiotensin-converting enzyme (ACE) gene polymorphism and COVID-19 phenotypic expression predisposed to SARS-CoV-2 infection

Ali,

Al-Marzoqi,

Rahmaan

2023

JANS

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Pathogenesis of COVID-19 has been linked to the Angiotensin system. Angiotensin-converting enzyme (ACE2) has been recognized as the specific receptor of the SARS-CoV-2 virus, serves as a cellular receptor for SARS-CoV-2, suggesting that a person's vulnerability to infection may be controlled by how much of the ACE2 gene is expressed. It is also possible that the severity of COVID-19 is related to the equilibrium between ACE1 and ACE2 activity, which has been linked to the etiology of respiratory disorders. This study aimed to investigate the association of ACE1 I/D polymorphism with the severity of Covid-19. The study looked at 113 people-(50 healthy controls, 63 people with Covid). Results for the ACE2 rs4240157 T > C polymorphism were obtained. Logistic regression was used to evaluate the distribution frequencies of variables across the study groups. The ACE1-CC*CT genotype (p = 0.049) and male gender (p0.001) were related to severe COVID-19. COVID-19 severity was found to be associated with the ACE2–CT genotype through multiple logistic regression under the co-dominant inheritance model: CC*CT Allele, 95% CI (0.0104 to 0.2954), Significance level, (0.0007) Odd Ratio (0.0556); CC*TT Allele, 95% CI (0.1854 to 6.1927), Significance level, (0.9386) Odd Ratio (1.0714); and CT*TT (19.2857). This was assuming the ACE2–CC*CT genotype was connected with covid-19 severity. However, the ACE2 polymorphism did not affect the development of illness. In conclusion, male gender, malignancy, and the ACE1 genotype were linked to a negative result of COVID-19. Our results indicated that ACE1-C/T might affect COVID-19 severity; however, this association was hypertensive status-specific. However, this finding needs to be confirmed in additional large samples.

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“…The rs4359 genotypes were identified using tetra-primer amplification-refractory mutation system (ARMS)-PCR method in a similar manner to our former study [ 19 ]. Specific primers for ARMS-PCR were designed using Primer1 tool.…”

Section: Methodsmentioning

confidence: 99%

Angiotensin I converting enzyme gene polymorphisms and risk of psychiatric disorders

et al. 2022

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Angiotensin-converting enzyme (ACE) as an important enzyme in the renin-angiotensin system facilitates biogenesis of the functionally active product angiotensin II from angiotensin I. ACE gene contains a number of functional polymorphisms which modulate activity of the encoded protein. In the current case–control study, we appraised the association between the rs4359 and rs1799752 polymorphisms and risk of bipolar disorder (type I and type II; BPDI and BPDII), schizophrenia (SCZ) and obsessive–compulsive disorder (OCD). The rs4359 was associated with risk of OCD, BPDI and BPDII in co-dominant and dominant models. The rs1799752 was associated with all assessed psychiatric conditions in four inheritance models except for BPDII whose association was not significant in recessive model. The I allele of rs1799752 was associated with OCD (adjusted FDR q-Value = 4.04E-04), SCZ (adjusted FDR q-Value = 6.00E-06), BPDI (adjusted FDR q-Value = 8.40E-03) and BPDII (adjusted FDR q-Value = 6.00E-06). The effective T allele of rs4359 showed a significant association with disease risk for BPDII group. The estimated haplotypes of these polymorphisms have been distributed differently among patients and controls. Taken together, ACE polymorphisms can be regarded as risk factors for a variety of psychiatric disorders.

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Polymorphisms in the angiotensin I converting enzyme (ACE) gene are associated with multiple sclerosis risk and response to Interferon-β treatment

Cited by 9 publications

References 17 publications

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

Cancer patients with Angiotensin-converting enzyme (ACE) gene polymorphism and COVID-19 phenotypic expression predisposed to SARS-CoV-2 infection

Angiotensin I converting enzyme gene polymorphisms and risk of psychiatric disorders

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