Polymorphisms in the +252(A/G) lymphotoxin‐alpha and the −308(A/G) tumor necrosis factor‐alpha genes and susceptibility to chronic periodontitis in a Czech population

Fassmann, Antonín; Hollá, Lýdie Izakovičová; Bučková, Dana; Vašků, Anna; Znojil, Vladimı́r; Vaněk, Jiřı́

doi:10.1034/j.1600-0765.2003.00661.x

Cited by 54 publications

(59 citation statements)

References 31 publications

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“…Several 103,104,105,106). These reports support the view of periodontitis as a disease that is largely dependent on the manner of the inflammatory response to components of the oral biofilm.…”

Section: Cytokines and Chemokinessupporting

confidence: 68%

Inflammatory mediators in the pathogenesis of periodontitis

Yucel‐Lindberg

Båge

2013

Expert Rev. Mol. Med.

352

334

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Periodontitis is a chronic inflammatory condition of the periodontium involving interactions between bacterial products, numerous cell populations and inflammatory mediators. It is generally accepted that periodontitis is initiated by complex and diverse microbial biofilms which form on the teeth, i.e. dental plaque. Substances released from this biofilm such as lipopolysaccharides, antigens and other virulence factors, gain access to the gingival tissue and initiate an inflammatory and immune response, leading to the activation of host defence cells. As a result of cellular activation, inflammatory mediators, including cytokines, chemokines, arachidonic acid metabolites and proteolytic enzymes collectively contribute to tissue destruction and bone resorption. This review summarises recent studies on the pathogenesis of periodontitis, with the main focus on inflammatory mediators and their role in periodontal disease.

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Section: Cytokines and Chemokinessupporting

confidence: 68%

Inflammatory mediators in the pathogenesis of periodontitis

Yucel‐Lindberg

Båge

2013

Expert Rev. Mol. Med.

352

334

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“…One of them, rs1041981, is exonic with a threonine-to-asparagine change (36) causing increased expression of adhesion molecules, such as VCAM-1 and E-selectin (37). The other SNP (rs909253) has been associated with periodontal disease (34,35), as well as with myocardial infarction (37), rheumatoid arthritis (38), and asthma (39). In our study, these two SNPs were associated with current periodontitis and the homozygous subjects had higher serum LTA concentrations.…”

Section: Discussionmentioning

confidence: 54%

“…It is expressed by lymphocytes (T, B, and natural killer cells) (31) and may exist in cell-bound and soluble forms (32). LTA gene polymorphism has also previously been associated with susceptibility to periodontitis (10,(33)(34)(35). In our study, five significant SNPs in the original study were located in the LTA gene and two of them were part of the risk haplotype.…”

Section: Discussionmentioning

confidence: 81%

Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis

et al. 2014

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Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (n ‫؍‬ 169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (P < 0.001) were replicated in Parogene 2 population samples (n ‫؍‬ 339) and the Health 2000 Survey (n ‫؍‬ 1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-␣ (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of >6 mm with the genes BAT1, NFKBIL1, and LTA. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, and rs1041981 (r 2 , >0.92), constituted a risk haplotype. In the Parogene 1 population, the haplotype had the strongest association with the parameter BOP, a PPD of >6 mm, and severe periodontitis with odds ratios (95% confidence intervals) of 2.63 (2.21 to 3.20), 2.90 (2.37 to 3.52), and 3.10 (1.63 to 5.98), respectively. These results were replicated in the other two populations. High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the LTA SNPs (rs909253 and rs1041981) of the haplotype. In addition, the protein was expressed in inflamed gingival connective tissue. We identified a novel BAT1-NFKBIL1-LTA haplotype as a significant contributor to the risk of periodontitis. The genetic polymorphisms in the MHC class III region may be functionally important in periodontitis susceptibility.

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“…44 IL-1 gibi periodontitisin patogenezinde önemli role sahip olan TNF-α'nın gen polimorfizmi ile periodontitis arasındaki ilişkiyi değerlendiren çalışmalara göre TNF-α geninin allel sıklığı da IL-1 gibi farklı etnik toplumlarda çeşitlilik gös-termektedir. TNF-α gen polimorfizmi ile periodontitis arasında ilişki olduğunu belirten çalış-malara 47 karşın, ilişkinin olmadığını ileri süren çalışmalar da [47][48][49][50][70][71][72][73] bulunmaktadır. Periodontal hastalıkta etkili olabilen bir diğer antienflamatuvar sitokin de IL-10'nun promoter polimorfizmleridir.…”

Section: Peridontal Hastalıkta Genetik Faktörlerin Rolüunclassified

Genes and Gene Polymorphisms Associated with Periodontal Diesases

Özçaka¹,

Bıçakçı²

2010

EÜ Dişhek Fak Derg

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Genetik polimorfizmler ile çeşitli medikal hastalıkların, kronik immün ve enflamatuvar durumların ilişkilerini inceleyen çalışmalar son on yılda bir artış göstermiştir. Günümüzde periodontal araştırmalar bu büyüyen alana katkıda bulunmaktadırlar. Bu yeni araştırmalar, gen ürünlerinin birbirleri ile olan fonksiyonel ilişkileri ve çevresel ajanlarla olan ilişkilerini anlamaya katkı sağlayan, genomu anlama yönünde de etkilemektedir. Bu araştırmaların sonuçları ışığında, periodontitisi de içine alan birçok hastalık için genetik temellerinin olduğuna dair kanıtlar ortaya çıkmaktadır. Bu kanıtlar da, hastalıkların genetik temellerini anlarsak hastalık riskini belirlemeye yönelik genetik testler ve etiyoloji temelli tedavilerin gelişimi de yakın zaman da gerçekleşecektir, fikrini desteklemektedir. Sonuç olarak, periodontal hastalıkların hastalık riskini belirlemede kullanılan genlerin allelik çeşitliliğini tanımlamak oldukça önemlidir.

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Polymorphisms in the +252(A/G) lymphotoxin‐alpha and the −308(A/G) tumor necrosis factor‐alpha genes and susceptibility to chronic periodontitis in a Czech population

Cited by 54 publications

References 31 publications

Inflammatory mediators in the pathogenesis of periodontitis

Inflammatory mediators in the pathogenesis of periodontitis

Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis

Genes and Gene Polymorphisms Associated with Periodontal Diesases

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