Polymorphisms in PDCD1 gene are not associated with aplastic anemia in Chinese Han population

Zhou, Ming; Hui, Huang; Miao, Maohua; Qiu, Yongchang; Zhang, X. G.

doi:10.1007/s00296-011-2127-0

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Furthermore, two recent studies suggested that the nonsynonymous Val215Ala SNP in the intracellular domain of PD-1 might also affect signal transduction. 19,20 We therefore focused on determining whether the PD-1.9 C/T SNP affected the development of SSPE. We found a lower frequency of the PD-1 rs2227982 T allele in Turkish SSPE patients.…”

Section: Discussionmentioning

confidence: 99%

PD-1 Gene Polymorphism in Children with Subacute Sclerosing Panencephalitis

et al. 2013

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Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. Several factors influence the risk of chronic brain infection with the mutant measles virus. However, to date, no pathogenic mechanism that may predispose to SSPE has been determined. Studies have indicated that specific polymorphisms in certain host genes are probably involved in impairing the ability of host immune cells to eradicate the measles virus in SSPE patients. Programmed cell death protein 1 (PD-1), a member of the CD28 family, is a negative regulator of the immune system. The purpose of our study was to investigate whether PD-1 gene polymorphisms affect susceptibility to the development of SSPE in Turkish children. In total, 109 subjects (54 SSPE patients and 55 healthy controls) were genotyped for the PD-1.9 C/T (rs2227982) single-nucleotide polymorphism (SNP). The distributions of T alleles in the PD-1.9 polymorphism in SSPE patients and healthy controls were 2.8 and 10.9%, respectively. There was a statistically significant difference between the groups; the 95% confidence interval (CI) was 0.06 to 0.85 and the odds ratio (OR) was 0.23 (χ(2) test). Thus, we identified an association between SSPE and the PD-1 rs2227982 gene polymorphism; the frequency of T alleles was higher in controls than in SSPE patients.

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Section: Discussionmentioning

confidence: 99%

PD-1 Gene Polymorphism in Children with Subacute Sclerosing Panencephalitis

et al. 2013

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“…Among single nucleotide polymorphisms (SNPs) in the human PD-1 gene (PDCD1) region, PD-1.1 G/A (rs36084323) was reported to have connection with autoimmune diseases [ 13 ]. Previous studies suggested that nonfunctional SNPs could affect gene function through haplotype tagging [ 14 ]. In this work, PD-1.1 G/A (rs36084323), a nonfunctional SNPs in PDCD1, was studied in a Chinese Han population, aiming to explore whether PD-1 expression was related to the variant of the SNP PD-1.1 G/A (rs36084323) and SLE Disease Activity Index (SLEDAI).…”

Section: Introductionmentioning

confidence: 99%

Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene

Jiao

Liu

Yang

et al. 2014

International Journal of Genomics

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real-time-reverse transcription polymerase chain reaction (RT-PCR). Also, whether PD-1 expression levels are associated with the variant of the SNP rs36084323 and the SLE Disease Activity Index (SLEDAI) was studied in this work. The PD-1 expression levels of SLE patients were significantly increased compared with those of the healthy controls. The upregulated PD-1 expression levels in SLE patients were greatly associated with SLEDAI scores. No significant difference was found between PD-1 expression levels and SNP rs36084323. The results suggest that increased expression of PD-1 may correlate with the pathogenesis of SLE, upregulated PD-1 expression may be a biomarker for SLE diagnosis, and PD-1 inhibitor may be useful to SLE treatment.

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“…In power system,peak-valley difference increases year by year,generation and T&D systems invest heavily to meet short-term peak load demand each year,so equipment utilization is inefficiency [1].Distribution network introduced BESS can do load shifting [2],reduce investment of power building capacity, decrease system losses,and make use of TOU price to reduce electricity tariff,meanwhile improving distribution system power supply reliability to minimize power losses.…”

Section: Introductionmentioning

confidence: 99%

Optimal Sizing of Battery Energy Storage System in Distribution Network

Ren

Liu³

2013

AMR

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Economical value including reducing investment in generation side as well as transmission and distribution (T&D) side of the building capacity and decreasing the power expenses for important users brought by BESS are studied.Economic benefits obtained by BESS through decreasing loss of power grid and making use of time of use (TOU) price to reduce electricity tariff are analysed.Considering the primarily capital cost and operation and maintenance (O&M) cost,the capacity optimal allocation model for different types of BESS is developed under optimal conomy condition and genetic algorithm is used to solve it.

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Polymorphisms in PDCD1 gene are not associated with aplastic anemia in Chinese Han population

Cited by 7 publications

References 27 publications

PD-1 Gene Polymorphism in Children with Subacute Sclerosing Panencephalitis

PD-1 Gene Polymorphism in Children with Subacute Sclerosing Panencephalitis

Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene

Optimal Sizing of Battery Energy Storage System in Distribution Network

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