Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients

Jiménez-Morales, Silvia; Martínez-Aguilar, Nora; Gamboa-Becerra, Roberto; Jiménez-Ruíz, Juan Luis; López-Ley, D. Y.; Li, Hong; Saldaña-Álvarez, Yolanda; Dean, Michael; Orozco, Lorena

doi:10.1016/j.humimm.2013.04.036

Cited by 21 publications

(23 citation statements)

References 46 publications

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“…For example, we previously reported an association between TNF and MMP9 SNPs and asthma in females [22,44]. Ours and other reports of gender association suggest that the interaction between genotype and sexual hormones plays a role during the development of asthma.…”

Section: Discussionsupporting

confidence: 59%

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

Martínez-Aguilar¹,

Río-Navarro²,

Navarro-Olivos³

et al. 2014

Journal of Asthma

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Section: Discussionsupporting

confidence: 59%

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

Martínez-Aguilar¹,

Río-Navarro²,

Navarro-Olivos³

et al. 2014

Journal of Asthma

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“…Jimenez-Morales et al . found that rs2274755 polymorphism was associated with asthma in Mexican pediatric patients [23], as was the case in Nakashima et al . 's study in a Japanese population [33].…”

Section: Discussionmentioning

confidence: 78%

“…rs243832 and rs7201 polymorphisms are associated with an increased risk of endometriosis [19]. rs3918249 polymorphism is associated with a decreased risk of glaucoma, especially in Caucasian patients [22], and an increased risk of childhood-onset asthma [23]; in the same study, rs2274755 polymorphism was also associated with an increased risk of asthma. Gao et al .…”

Section: Introductionmentioning

confidence: 99%

A single-nucleotide polymorphism inMMP9is associated with decreased risk of steroid-induced osteonecrosis of the femoral head

Liu

Jin

et al. 2016

Oncotarget

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Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the “CGC” MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.

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“…Most studies in Latin Americans include one of a few subgroups (Mexicans, Puerto Ricans, Costa Ricans, Colombians or Brazilians) and focus on replicating candidate genes identified in other populations (e.g. transforming growth factor beta 1 (TFGB1), 21 the 17q21 locus, 22 23 interleukin 13 (IL13), 24 gluthatione S-transferase mu 1 (GSTM1), 25 matrix metallopeptidase 9 (MMP9) 26 and the beta2-adrenergic receptor (ADRB2)). 27 28 On the other hand, two susceptibility genes for asthma-related phenotypes first identified in Latin Americans include thymic stromal lymphopoietin (TSLP) 29 and matrix metalloproteinase 12 (MMP12).…”

Section: Ancestry Genetics and Epigeneticsmentioning

confidence: 99%

Asthma in Latin America

Forno

Gogna

Cepeda

et al. 2015

Thorax

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Consistent with the diversity of Latin America, there is profound variability in asthma burden among and within countries in this region. Regional variation in asthma prevalence is likely multifactorial and due to genetics, perinatal exposures, diet, obesity, tobacco use, indoor and outdoor pollutants, psychosocial stress, and microbial or parasitic infections. Similarly, nonuniform progress in asthma management leads to regional variability in disease morbidity. Future studies of distinct asthma phenotypes should follow up well-characterized Latin American subgroups and examine risk factors that are unique or common in Latin America (e.g. stress and violence, parasitic infections and use of biomass fuels for cooking). Because most Latin American countries share the same barriers to asthma management, concerted and multifaceted public health and research efforts are needed, including approaches to curtail tobacco use, campaigns to improve asthma treatment, broadening access to care and clinical trials of non-pharmacologic interventions (e.g. replacing biomass fuels with gas or electric stoves).

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Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients

Cited by 21 publications

References 46 publications

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

A single-nucleotide polymorphism inMMP9is associated with decreased risk of steroid-induced osteonecrosis of the femoral head

Asthma in Latin America

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