<i>SPINK5</i>and<i>ADRB2</i>haplotypes are risk factors for asthma in Mexican pediatric patients

Martínez-Aguilar, Nora; Río-Navarro, Blanca Estela Del; Navarro-Olivos, Efraín; Garcia‐Ortíz, Humberto; Orozco, Lorena; Jiménez-Morales, Silvia

doi:10.3109/02770903.2014.966913

Cited by 15 publications

(14 citation statements)

References 57 publications

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“…SPINK5 encodes an inhibitor of multiple serine proteases, including plasmin, neutrophil elastase, and trypsin, and mutations in this gene have been associated with Netherton syndrome [29]. SPINK5 polymorphisms/haplotypes have also been associated with asthma susceptibility in numerous populations [30–32]. The upregulation of SPINK5 in controls at T2 suggests it may be important in epithelial repair.…”

Section: Discussionmentioning

confidence: 99%

Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence

et al. 2017

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BackgroundRhinovirus (HRV) is associated with the large majority of virus-induced asthma exacerbations in children and young adults, but the mechanisms remain poorly defined.MethodsAsthmatics and non-asthmatic controls were inoculated with HRV-A16, and nasal epithelial samples were obtained 7 days before, 36 hours after, and 7 days after viral inoculation. RNA was extracted and subjected to RNA-seq analysis.ResultsAt baseline, 57 genes were differentially expressed between asthmatics and controls, and the asthmatics had decreased expression of viral replication inhibitors and increased expression of genes involved in inflammation. At 36 hours (before the emergence of peak symptoms), 1329 genes were significantly altered from baseline in the asthmatics compared to 62 genes in the controls. At this time point, asthmatics lacked an increase in IL-10 signaling observed in the controls. At 7 days following HRV inoculation, 222 genes were significantly dysregulated in the asthmatics, whereas only 4 genes were dysregulated among controls. At this time point, the controls but not asthmatics demonstrated upregulation of SPINK5.ConclusionsAs judged by the magnitude and persistence of dysregulated genes, asthmatics have a substantially different host response to HRV-A16 infection compared with non-asthmatic controls. Gene expression differences illuminate biologically plausible mechanisms that contribute to a better understanding of the pathogenesis of HRV-induced asthma exacerbations.

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Section: Discussionmentioning

confidence: 99%

Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence

et al. 2017

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“…The included studies were published between 2010 and 2020 and conducted in 11 countries: China, Indian, Egypt, Jordan, Poland, Mexico, Saudi Arabia, Colombia, Chile, Turkey, and Tunisia. A total of 18 polymorphisms in 7 genes were identified for data synthesis: IL-13 +2044G/A (rs20541), [ 10 – 15 ] IL-13 -1112C/T (rs1800925), [ 11 , 13 , 15 – 19 ] IL-13 +1923C/T (rs1295686), [ 20 – 22 ] IL-4 - 590C/T (rs2243250), [ 12 , 15 – 19 , 21 , 23 – 28 ] ADRB2 -46 G /A (rs1042713), [ 11 , 15 , 21 , 29 – 37 ] ADRB2 -79G/C (rs1042713), [ 29 , 31 – 35 , 38 ] ADAM33 F+1 (rs511898), [ 39 – 42 ] ADAM33 V4 (rs2787094), [ 39 , 40 , 43 – 45 ] ADAM33 S2 (rs528557), [ 15 , 39 , 41 , 44 , 45 ] ADAM33 T2 (rs2280090), [ 40 , 43 – 46 ] ADAM33 T1 (rs2280091), [ 40 , 41 , 44 , 45 ] ADAM33 ST+4 (rs44707), [ 39 , 47 , 48 ] ORMDL3 rs7216389, [ 49 – 52 ] VDR Apa I (rs7975232), [ 53 – 59 ] VDR Fok I (rs2228570), [ 53 – 55 , 57 , 58 , 60 , 61 ] VDR ...…”

Section: Resultsmentioning

confidence: 99%

Asthma susceptible genes in children

et al. 2020

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“…A total of 3420 cases and 4808 controls from 17 studies [20–22,26–28,30–32,34,39–41,43,45,46,49] were included in our meta-analysis. Random-effects model was used to calculate the pooled OR and 95% CI because of the presence of moderate heterogeneity in dominant and codominant model (TC vs CC) ( I 2 = 57.2%, P < 0.05), fixed-effects model in other models (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…However, the data have yielded conflicting results. [11,21,30–36] Therefore, we performed this updated meta-analysis to investigate the more precise association between the CD14 −159C/T variant and asthma risk.…”

Section: Discussionmentioning

confidence: 99%

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Yang

Zhou

et al. 2016

Medicine

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Background:It has been reported that the cluster of differentiation 14 (CD14) gene −159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association.Methods:A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. We used I2 to assess heterogeneity, and a funnel plot and Egger test to assess publication bias.Results:In total, 34 studies involving 15,641 subjects were included in this meta-analysis. There was a statistically significant association between CD14 −159C/T polymorphism and asthma risk observed in dominant model (TT+TC vs CC: OR = 0.86, 95% CI = 0.77–0.97, P = 0.012) and codominant model (TC vs CC: OR = 0.88, 95% CI = 0.78–0.99, P = 0.035) in adults. However, there may be no significant association between CD14 159C/T and atopic and nonatopic asthma risk.Conclusion:In summary, the overall results suggested that the CD14 −159C/T variant may decrease the risk of asthma susceptibility in adults. However, no significant association between CD14 159C/T and atopic and nonatopic asthma susceptibility was identified. More studies with larger sample size are needed to validate the findings from this study.

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SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

Abstract: Our results suggest that SPINK5 and ADRB2 haplotypes might play a role in the susceptibility to childhood-onset asthma.

Cited by 15 publications

References 57 publications

Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence

Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence

Asthma susceptible genes in children

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

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