Polymorphisms in human pre-miRNAs

Iwai, Naoharu; Naraba, Hiroaki

doi:10.1016/j.bbrc.2005.04.051

Cited by 189 publications

(125 citation statements)

References 14 publications

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“…7 A few studies have been performed that examined sequence variations in miRNA regions. 7,8,13,14 For example, Hu et al 8 found that rs11614913 in the pre-miRNA-196a2 was associated with an increase in mature miRNA expression, which contributes to the development and prognosis of lung cancer. In this study, we found a positive association between rs2292832 in miR-149 and CWP risk.…”

Section: Discussionmentioning

confidence: 99%

Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

et al. 2009

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microRNAs (miRNAs) are an abundant class of small noncoding RNA molecules thought to be involved in biological functions, including embryonic development, chromosome architecture, cell proliferation and apoptosis. We hypothesized that common variants in the miRNAs are associated with risk of coal workers' pneumoconiosis (CWP). In a case-control study of 496 CWP patients and 513 control subjects frequency matched by exposure years and work types, we genotyped four single-nucleotide polymorphisms (SNPs) (rs2910164, rs2292832, rs11614913 and rs3746444) in pre-miRNAs (miR-146a, miR-149, miR196a2 and miR-499) and assessed the associations with risk of CWP. A significantly increased risk of CWP was found for the miR-149 rs2292832 TT genotype (odds ratio (OR), 1.31; 95% confidence interval (CI), 1.01-1.69), compared with the CT/CC genotypes, and this increased risk was evident among subgroups of those aged X68 years (OR¼1.52, 95% CI¼1.03-2.25), dust exposure X26 years (OR¼1.42, 95% CI¼1.04-1.93) and ever smokers (OR¼1.48, 95% CI¼1.00-2.20). Furthermore, a significant association was observed between the genotypes and patients with stages II and III (OR¼1.50, 95% CI¼1.05-2.14 for stage II, and OR¼3.33, 95% CI¼1.67-6.65 for stage III). These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP.

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Section: Discussionmentioning

confidence: 99%

Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

et al. 2009

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“…Sequence variation in or near the majority of microRNA (miRNA) genes seems to be restrained by evolutionary selection pressure (12,13), emphasizing the central role of these small molecules in modulating gene regulatory networks. The MIR148A gene is quite polymorphic, however, and variation in the gene region exhibits marked population differentiation representing one of the strongest signatures of selection among 117 miRNA regions tested throughout the genome (14).…”

Section: Significancementioning

confidence: 99%

Genetic interplay betweenHLA-CandMIR148Ain HIV control and Crohn disease

Kulkarni

Ying

Ó'hUigín

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Significance In the human population different HLA-C allotypes are present that have different expression levels at the cell surface. Individuals with higher expressed HLA-C allotypes demonstrate better HIV control but increased risk of Crohn disease. A microRNA, miR-148a, regulates expression of some HLA-C allotypes. We report here that this microRNA also varies in expression level between people. MIR148A variation showed significant and opposing effects on HIV viral control vs. risk of Crohn disease, specifically in subjects with HLA-C alleles that are regulated by miR-148a. These results are independent of confounding effects by other HLA loci because only HLA-C is regulated by miR-148a. Our data represent an example of gene interactions that affect immune response and thereby the risk of human disease.

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“…27 Overexpression of miR-146a corresponds to loss of various tumor suppressor genes and receptors associated with signaling pathways that has vital functions in cell growth and immune recognition. 28 Overexpression of miR-146a has been reported as a signature in various cancers.…”

Section: Discussionmentioning

confidence: 99%

Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population

Srivastava

Mittal

2010

J Hum Genet

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MicroRNAs (miRNAs) are small, non-coding RNA molecules that function as negative regulators of gene expression. Common genetic variants (single nucleotide polymorphisms, SNPs) in miRNA genes may alter their expression or maturation resulting in varied functional consequences. Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for the association of individual SNPs and their interactions with GBC. A non-significant increased risk was observed between carriers of variant genotypes of rs2910164, rs11614913 and rs3746444 (ORs¼1.3, 1.3 and 1.1, respectively). This increased risk was more profound in GBC patients with gallstones (ORs¼1.4, 1.6 and 1.1, respectively). To further evaluate the cumulative effects of the variant allele, we did a combined unfavorable genotype analysis, which showed a borderline statistical significance. In comparison with the low-risk group (0-2 variant alleles), the high-risk group (42 variant alleles) had a 1.7-fold (95% CI¼1.0-2.8) increased risk for GBC (P trend ¼0.056). These findings suggest, for the first time, that common miRNA variants may not contribute to GBC susceptibility in North Indian population.

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Polymorphisms in human pre-miRNAs

Cited by 189 publications

References 14 publications

Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

Genetic interplay betweenHLA-CandMIR148Ain HIV control and Crohn disease

Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population

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