Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

Wang, Meilin; Yang, Ye; Qian, Haiyang; Song, Zhifang; Jia, Xiaomin; Zhang, Zhengdong; Zhou, Jianwei; Ni, Chunhui

doi:10.1038/jhg.2009.112

Cited by 40 publications

(22 citation statements)

References 17 publications

(17 reference statements)

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“…Rs2292832 in has-miR-149 has been reported to be involved in susceptibility with gastric cancer risk (40), head and neck squamous cell carcinoma risk (41), as well as coal workers' pneumoconiosis risk (26). However, only Rs71428439 in has-miR-149 was observed to be associated with the risk of MI in our study.…”

contrasting

confidence: 54%

A Pre-microRNA-149 (miR-149) Genetic Variation Affects miR-149 Maturation and Its Ability to Regulate the Puma Protein in Apoptosis

Ding

Jiao

et al. 2013

Journal of Biological Chemistry

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contrasting

confidence: 54%

A Pre-microRNA-149 (miR-149) Genetic Variation Affects miR-149 Maturation and Its Ability to Regulate the Puma Protein in Apoptosis

Ding

Jiao

et al. 2013

Journal of Biological Chemistry

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“…Six hundred and ninety-seven CWP patients and 694 controls were recruited from the coal mines of Xuzhou Mining Business Group Co., Ltd. between January 2006 and December 2010, as described previously [27]. In brief, all subjects were underground coal miners and spent their entire working career within the above mentioned company.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Hou

Wang

et al. 2012

PLoS ONE

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BackgroundCoal workers' pneumoconiosis (CWP), resulting from the inhalation of silica-containing coal mine dust, is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Recently, it has been hypothesized that inflammasomes could have a crucial role in the host response to silica and recent studies show that the inflammasome contributes to inflammation and pulmonary fibrosis. NLRP3, CARD8 are components of the NLRP3 inflammasome, which triggers caspase 1-mediated IL-1β and IL-18 release. In the present study, we investigated whether common single nucleotide polymorphisms (SNPs) in inflammasome genes are associated with CWP.MethodsWe performed an association study analyzing 3 NLRP3, 1 CARD8, 1 IL-1β, 2 IL-18 SNPs in a case-control study of 697 CWP and 694 controls. Genotyping was carried out by the TaqMan method.ResultsThe NLRP3 rs1539019 TT genotype was associated with a significantly increased risk of CWP (adjusted odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.07–1.81), compared with the GG/GT genotype, in particular among smokers (adjusted OR = 1.67, 95%CI = 1.15–2.42). In addition, the polymorphism was significantly associated with risk of CWP patients with stage I.ConclusionsThis is the first report showing an association between the NLRP3 rs1539019 polymorphism and CWP, and suggests that this polymorphism may confer increased risk for the development of the disease. Further studies are warranted to confirm our findings.

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“…From January 2006 to December 2010, 694 healthy males and 697 males with definite CWP were recruited from the coal mines of Xuzhou Mining Business Group Co., Ltd., as described previously [11]. All subjects in our study were ethnic Han Chinese without a direct family/genetic relationship.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in SPARC and Coal Workers' Pneumoconiosis Risk in a Chinese Population

et al. 2014

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BackgroundThe SPARC is a crucial matricellular protein and may influence the course of various diseases like tumor metastasis and fibrosis. In the present study, we investigated the association between the potential functional polymorphisms in SPARC and coal workers' pneumoconiosis (CWP) risk in a Chinese population.MethodsFive potentially functional polymorphisms (rs1059279, rs1059829, rs1053411, rs2304052 and rs4958281) in SPARC were genotyped and analyzed in a case-control study including 697 CWP cases and 694 controls. The genotyping was used by the TaqMan method with the ABI 7900HT Real Time PCR system.ResultsOur results revealed that three SNPs (rs1059279, rs1059829, rs1053411) were significantly associated with increased risk of CWP under an additive model (OR = 1.35, 95%CI = 1.06–1.71, P = 0.015 for rs1059279; OR = 1.20, 95%CI = 1.03–1.39, P = 0.021 for rs1059829; OR = 1.31, 95%CI = 1.03–1.65, P = 0.025 for rs1053411). In the stratification analysis, significant associations were observed between each of these three SNPs and patients with 0–20 pack-years of smoking (OR = 1.73, 95%CI = 1.21–2.45 for rs1059279; OR = 1.48, 95%CI = 1.07–2.05 for rs105982; OR = 1.58, 95%CI = 1.13–2.22 for rs1053411). Furthermore, the association between rs1059279 and CWP risk remained significant among subjects with over 27 years of exposure (OR = 1.27, 95%CI = 1.03–1.56, P = 0.023). In the combined analysis of these five polymorphisms, individuals with multiple risk alleles had a higher risk of CWP (Ptrend = 0.015).ConclusionOur results indicate that three functional SPARC SNPs are associated with an increased risk of CWP in a Chinese population. Further functional research and validation studies with diverse populations are warranted to confirm our findings.

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Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis

Cited by 40 publications

References 17 publications

A Pre-microRNA-149 (miR-149) Genetic Variation Affects miR-149 Maturation and Its Ability to Regulate the Puma Protein in Apoptosis

A Pre-microRNA-149 (miR-149) Genetic Variation Affects miR-149 Maturation and Its Ability to Regulate the Puma Protein in Apoptosis

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Polymorphisms in SPARC and Coal Workers' Pneumoconiosis Risk in a Chinese Population

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