Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens

Abstract

ABSTRACT. In the past, the focus of broiler breeding programs on yield and carcass traits improvement led to problems related to meat quality. Awareness of public concern for quality resulted in inclusion of meat quality traits in the evaluation process. Nevertheless, few genes associated with meat quality attributes are known. Previous studies mapped quantitative trait loci for weight at 35 and 42 days in a region of GGA4 flanked by the microsatellite markers, MCW0240 and LEI0063. In this region, there are 2 fibroblast growth factor binding protein (FGFBP) genes that play an important role in embryogenesis, cellular Associations of FGFBP1 and FGFBP2 polymorphisms in chickens differentiation, and proliferation in chickens. The objective of this study was to identify and associate single nucleotide polymorphisms (SNPs) in FGFBP1 and FGFBP2 with performance, carcass, and meat quality in experimental and commercial chicken populations. In the commercial population, SNP g.2014G>A in FGFBP1 was associated with decreased carcass weight (P < 0.05), and SNP g.651G>A in FGFBP2 was associated with thawing loss and meat redness content (P < 0.05). Four haplotypes were constructed based on 2 SNPs and were associated with breast weight, thawing loss, and meat redness content. The diplotypes were associated with thawing loss, lightness, and redness content. The SNPs evaluated in the present study may be used as markers in poultry breeding programs to aid in improving growth and meat quality traits.

Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4

“…Initial investigations of this region have resulted in the identification of a polymorphism located at 76,163,331 bp G>A on FGFBP1 (protein binding growth factor fibroblast 1), which is associated with eviscerated carcass weight in a commercial broiler line. This polymorphism is also associated with protein and ash content in Embrapa F 2 chicken population (Felício et al, 2013).…”

Fine mapping of a distal chromosome 4 QTL affecting growth and muscle mass in a chicken advanced intercross line

“…Polymorphisms within the fibroblast growth factor binding protein 1 and 2 ( FGFBP1 and FGFBP2 ) genes were reported by Felício et al . () to have an association with carcass traits in chicken. Hoppman et al .…”

Effects of feeding conditions on gene expression in chicken breast muscle

“…Many genes are associated with the quality of chicken meat (Liu et al, 2013), such as the fibroblast growth factor-binding protein (Felício et al, 2013) and fatty acid-binding protein (FABP) gene families (Li et al, 2006), MYBPC1, CETP, GLTPD1, SNX4 (Cui et al, 2012), and MSTN1 genes (Xu et al, 2015). Although many previous studies have investigated chicken meat quality, the mechanisms underlying these quality traits are unknown.…”