Polymorphisms in Cytokine Genes and Their Association with Acute Rejection and Recurrence of Hepatitis B in Chinese Liver Transplant Recipients

Xie, Hai; Wang, Wei Lin; Yao, Min; Yu, Song; Feng, Xiao; Jin, Jing; Jiang, Zhi; Wu, Liming; Zheng, Shu

doi:10.1016/j.arcmed.2008.01.003

Cited by 33 publications

(24 citation statements)

References 48 publications

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“…The results from these studies and those from our research were strongly influenced by patient ethnicity. In the study reported by Mas et al (2004), the IL10 AA genotype in Caucasians at position -1082 occurred in 32.5% of patients, while in Han Chinese (Xie et al, 2008) it occurred in 88.2% of patients; the figure was 85.45% in our study. Therefore, apparent discrepancies might be due to cytokine frequency differences among the different ethnic backgrounds.…”

Section: Discussionsupporting

confidence: 49%

“…Although some studies have shown an effect on rejection (Warlé et al, 2002;Rattanasiri et al, 2013), others have shown no association (Conti et al, 1998;Xie et al, 2008). The regulatory-type cytokines, such as transforming growth factor-b1 (TGF-b1), may influence both TH1-and TH2-type cytokines in the immune response (Liu et al, 2009), and some researchers have reported that they are upregulated in rejection (Eikmans et al, 2002), while others have reported no relationship (Eurich et al, 2011;Rattanasiri et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation

Rj²,

Wang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphisms in the genes encoding interleukin-10 (IL10), transforming growth factor-b1 (TGFB1), and tumor necrosis factor-a (TNF), and the risk of AR recurrence. We enrolled 359 LT recipients; they were divided into two groups: an AR group (N = 165) and a non-AR group (N = 194) according to whether they experienced rejection within the first month following liver transplantation. After providing informed consent, blood was collected and DNA was extracted. The single nucleotide polymorphisms of IL10 (-1082, -819, and -592), TGFB1 (+869 and +915), and TNF (-308) were investigated according to the methods used in previous studies. A significant difference was observed in the distribution of allelic frequencies at position +869 in TGFB1 between the AR and non-AR groups (P = 0.000). However, no significant differences (P > 0.05) were found in the genotype distributions in IL10, TNF, and TGFB1 between the AR and non-AR groups. Our study suggests that the +869 gene polymorphism of TGFB1 is significantly associated with liver graft rejection, while the other gene polymorphisms investigated in IL10, TNF, and TGFB1 are probably not risk factors for AR in LT recipients.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation

Rj²,

Wang

et al. 2016

Genet. Mol. Res.

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“…A number of genes contribute to the difference in the cytokine levels observed in individuals; however, the mechanism of function of these genes has not been fully understood [7][17][18]. Because cytokines regulate the immune response, polymorphisms in cytokine genes or variations in their expression may affect an individual's susceptibility to infectious diseases [19][20].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Transforming Growth Factor-β1 Gene Polymorphisms Among Iranian Patients With Chronic Hepatitis C

Romani

Azimzadeh²,

Mohebbi

et al. 2011

Hpat Mon

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BackgroundChronic hepatitis C infection is caused by the hepatitis C virus (HCV), and its clinical complications include liver cirrhosis, liver failure, and hepatocellular carcinoma.Transforming growth factor-β1 (TGF-β1) is an important cytokine in cell growthand differentiation, angiogenesis, extracellular matrix formation, immune responseregulation, and cancer development and progression.ObjectivesThe aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in TGF-β1 and chronic HCV infection among patients referred to the Taleghani Hospital, Tehran, Iran between 2008 and 2010.Patients and MethodsIn this case-control study, samples were collected using a convenience sampling method. We genotyped 164 HCV patients and 169 healthy controls for 3 SNPs in the TGF-β1 gene (-509 promoter, codon 10, and codon 25). We determined the SNP genotypes by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. To confirm the PCR-RFLP genotyping results, 10% of the samples were re-genotyped using a direct sequencing method.ResultsThere were no significant differences in the allelic frequency distribution of SNPs at -509 C/T, +869 C/T, or +915 G/C between HCV patients and the healthy controls. Genotyping results for all three polymorphic sites were similar with no statistically significant differences between the groups.ConclusionsMost of the Iranian patients (over 85%), both healthy controls and HCV patients, had the GG genotype at the +915 G/C position, resulting in a high level of TGF-β1 production. Therefore, we concluded that the SNPs investigated by us cannot be considered as prognostic factors for HCV infection in our population, despite being reported as prognostic markers in other populations. Moreover, there is a possibility that most of the population is susceptible to HCV infection.

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“…Therefore, the study performed by We updated this analysis with a literature search (the last update was performed on March 1, 2011). Three additional studies [4][5][6] were found for the IL-10-1082 G/A polymorphism and acute rejection in liver transplant recipients. When we included the 3 studies, the pooled OR for the A allele versus the G allele was 0.79 (95% CI ¼ 0.60-1.05) in a fixed effect model and 0.82 (95% CI ¼ 0.58-1.17) in a random effect model.…”

mentioning

confidence: 99%

Need for the clarification of data in a recent meta-analysis about cytokine gene polymorphisms and acute liver graft rejection

Liu

Yue

et al. 2011

Liver Transpl

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Polymorphisms in Cytokine Genes and Their Association with Acute Rejection and Recurrence of Hepatitis B in Chinese Liver Transplant Recipients

Cited by 33 publications

References 48 publications

Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation

Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation

Investigation of Transforming Growth Factor-β1 Gene Polymorphisms Among Iranian Patients With Chronic Hepatitis C

Need for the clarification of data in a recent meta-analysis about cytokine gene polymorphisms and acute liver graft rejection

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