Polymorphisms in Base Excision Repair Genes as Colorectal Cancer Risk Factors and Modifiers of the Effect of Diets High in Red Meat

Brevik, Asgeir; Joshi, Amit D.; Corral, Román; Onland‐Moret, N. Charlotte; Siegmund, Kimberly D.; Marchand, Loı̈c Le; Baron, John A.; Martı́nez, Marı́a Elena; Haile, Robert W.; Ahnen, Dennis J.; Sandler, Robert S.; Lance, Peter; Stern, Mariana C.

doi:10.1158/1055-9965.epi-10-0606

Cited by 70 publications

(37 citation statements)

References 23 publications

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“…Our present study found no association between the XRCC1 gene heterozygous polymorphism (G399A) and the risk of colorectal cancer. This is consistent with the negative findings of the cohort study of a Singapore Chinese population (Stern et al, 2007) and previous case-control studies (Brevik et al, 2010;Kabzinski et al, 2010;Engin et al, 2011;Gsur et al, 2011;Yin et al, 2012;Przybylowska et al, 2013). The negative finding has also been confirmed in several meta-analyses Liu et al, 2013;Yi et al, 2013).…”

Section: Discussionsupporting

confidence: 91%

“…The negative finding has also been confirmed in several meta-analyses Liu et al, 2013;Yi et al, 2013). The positive finding that the XRCC1 homozygous A allele was associated with a higher risk of CRC is also consistent with previous case-control studies (Brevik et al, 2010;Kabzinski et al, 2010;Engin et al, 2011;Gsur et al, 2011;Przybylowska et al, 2013).…”

Section: Discussionsupporting

confidence: 88%

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XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. This study aimed to investigate the interaction between the presence of a polymorphism of the XRCC1 gene and known risk factors for colorectal cancer in Thailand. Materials and Methods: A hospital-based case-control study was conducted in Thailand. The participants were 230 histologically confirmed new cases and 230 controls matched by sex and age and recruited from the same hospital. Information about demographic characteristics, life style, and dietary habits was collected using structured interviews, and blood samples were taken which were used for the detection of a homozygous and heterozygous polymorphisms of XRCC1. Associations were assessed using multiple conditional logistic regression. Results: In the univariate analysis, factors found to be significantly associated with an increased risk for CRC were the presence of the XRCC1 AA homozygote (OR= 4.95; 95% CI: 1.99-12.3), a first degree family history of cancer (OR= 1.74; 95% CI: 1.18-2.58), and a high frequency of pork consumption (OR= 1.49; 95% CI: 1.00-2.21). Intakes of fish fruit and vegetables appeared to be protective factors, but the associations were not statistically significant. In the multivariate analysis only the XRCC1 AA homozygote polymorphism and a family history of cancer emerged as risk factors (OR= 4.96; 95% CI: 1.90-12.95 and OR=1.80; 95% CI: 1.18-2.72, respectively). Conclusions: While the XRCC1 AA homozygote and a family history of cancer were found to be associated with an increased risk of CRC, none of the dietary intake variables were clearly identified as risk or protective factors. There is a need for further research to determine the reasons for this.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Thirty five studies were included based on the search criteria for CRC susceptibility related to the XRCC1 Arg399Gln polymorphisms (Abdel-Rahman et al, 2000;Krupa et al, 2004;Hong et al, 2005;Skjelbred et al, 2006;Ren et al;Moreno et al, 2006;Jin et al, 2007;Stern et al, 2007;Yeh et al, 2007;Martinez-Balibrea et al, 2008;Pardini et al, 2008;Kasahara et al, 2008; Song et al, 2008;Sliwinski et al, 2008;Improta et al, 2008;Curtin et al, 2009;Brevik et al, 2010;Jelonek et al, 2010;Canbay et al, 2011;Engin et al, 2011;Gsur et al, 2011;Huang et al, 2011;Zhu et al, 2011;Muniz-Mendoza et al, 2012;Yin et al, 2012;Zhao et al, 2012;Gil et al, 2013;Khan et al, 2013;Li et al, 2013;Przybylowska et al, 2013;Procopciuc et al, 2013;Nissar et al, 2014;Poomphakwaen et al, 2014;Zhang et al, 2014). Study characteristics were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies

Forat-Yazdi

Gholi-Nataj²,

Neámatzadeh³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce effectiveness of DNA repair and be associated with risk of certain cancers. In this study we aimed to clarify any association between XRCC1 Arg399Gln and colorectal cancer (CRC) risk by performing a meta-analysis of published case-control studies. Materials and Methods: PubMed and Google Scholar were searched to explore the association between XRCC1 and CRC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength.

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“…Zhang et al [21] found that smoking significantly affects the association between XRCC1 399Arg/Gln and CRC risk in certain Chinese populations. Moreover, Brevik et al [22] showed that free radical damage generated by a diet rich in red meat plays a significant contribution to the development of CRC.…”

Section: Discussionmentioning

confidence: 99%

XRCC1 Gene Polymorphisms and miR-21 Expression in Patients with Colorectal Carcinoma

et al. 2017

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Objective: The objectives of this study were to evaluate the impact of two X-ray repair cross complementing 1 (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) on the risk of development of colorectal cancer (CRC) and to assess the expression levels of microRNA-21 (miR-21) in CRC patients. Materials and Methods:A case-control cross sectional study was conducted on 50 CRC patients and 50 cancer-free subjects. DNA and miR-21 were extracted from whole blood samples. The expression levels of the XRCC1 polymorphisms and miR-21 were assessed by real-time PCR in all subjects of the study.Results: Genotype analysis revealed a significant association between CRC risk and both the Arg194Trp genotype (OR=11.407, 95% CI=4.039-32.221, p<0.001) and the Arg399Gln genotype (OR=3.778, 95% CI= 1.6-8.919, p=0.002). The expression levels of circulating miR-21 were able to detect CRC cases significantly (p=0.022) with a sensitivity of 82% and a specificity of 56% (Area under the curve (AUC)=0.633) but were unable to distinguish between early and late cases (AJCC classification) (p=0.194). Conclusion:The XRCC1 Arg194Trp and Arg399Gln polymorphisms both confer high susceptibility for the development of CRC. Circulating miR-21 expression levels are a potentially diagnostic non-invasive genetic marker of CRC.Keywords: Colorectal cancer, miRNA-21, XRCC1, DNA repair, single nucleotide polymorphisms ÖZ Amaç: Bu çalışmanın amacı iki XRCC1 gen polimorfizminin (Arg194Trp ve Arg399Gln) kolorektal kanser (KRK) gelişimi riski üzerindeki etkisini değerlendirmek ve KRK hastalarında microRNA-21 (miR-21) ekspresyonu düzeylerini incelemektir.Gereç ve Yöntemler: 50 KRK hastası ve 50 kansersiz denekle vaka-kontrollü bir kesitsel çalışma gerçekleşti-rildi. Tüm kan numunelerinden DNA ve miR-21 alındı. XRCC1 polimorfizmlerinin ve miR-21'in ekspresyon seviyeleri, çalışmadaki tüm deneklerde gerçek zamanlı PCR ile değerlendirildi. Bulgular: Genotip analizinde KRK riski ile Arg194Trp (OR=11.407, 95% CI=4.039-32.221, p<0,001) ve Arg399Gln (OR=3.778, 95% CI=1, p=0,002) genotipleri arasında önemli bir ilişki ortaya konuldu. Dolaşımdaki miR-21 ekspresyon düzeyleriyle KRK olguları %82 duyarlılık ve %56 özgüllük (AUC=0,633) ile anlamlı bir şekilde (p=0,022) saptanabildi, ancak erken ve geç vakalar ayırt edilemedi (AJCC sınıflandırması) (p=0,194).Sonuç: XRCC1 Arg194Trp ve Arg399Gln polimorfizmlerinin her ikisi de KRK gelişimine yüksek düzeyde yatkınlık göstermektedir. Dolaşımdaki miR-21 ekspresyon seviyeleri potansiyel olarak KRK'nın tanısal noninvasiv genetik belirtecidir.Anahtar Kelimeler: Kolorektal kanser, miRNA-21, XRCC1, DNA onarımı, SNPs Eurasian J Med 2017; 49: 132-6 Original Article

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Polymorphisms in Base Excision Repair Genes as Colorectal Cancer Risk Factors and Modifiers of the Effect of Diets High in Red Meat

Cited by 70 publications

References 23 publications

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies

XRCC1 Gene Polymorphisms and miR-21 Expression in Patients with Colorectal Carcinoma

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