Polymorphisms and Haplotypes in the XRCC1 Gene and the Risk of Advanced Non-Small Cell Lung Cancer

Kim, In-Suk; Lee, Gyeong‐Won; Kim, Dong Chul; Kim, Hoon-Gu; Kim, Sun‐Joo; Oh, Sung Yong; Kim, Sung-Hyun; Kwon, Hyuk‐Chan

doi:10.1097/jto.0b013e3181f46708

Cited by 17 publications

(8 citation statements)

References 38 publications

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“…The data showed that there is no association between SNPs and NSCLC risk in never smokers and this is the first study in a Chinese population to show this patten. However, the present data were markedly discordant with that of previously published studies (Chang et al, 2009;Kim et al, 2010;Wang et al, 2010). The reason for this discrepancy is unknown, but ethnic background of such patient population may play a role in it.…”

Section: Discussionsupporting

confidence: 64%

“…Meanwhile, rs401681 (Wang et al, 2008) and rs4975616 (Broderick et al, 2009;Wang et al, 2010)were associated with a significant decrease in lung cancer risk in Europeans. Another study showed a stronger association of rs1001581 heterozygote with the increased NSCLC risk in Korean (Kim et al, 2010). Thus, the present study investigated the polymorphisms of XRCC1 and CLPTM1L for association with NSCLC risk in never-smoking Chinese.…”

Section: Introductionmentioning

confidence: 86%

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No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Sun¹,

Zhang²,

Kong³

2013

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 86%

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Sun¹,

Zhang²,

Kong³

2013

Asian Pacific Journal of Cancer Prevention

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“…Chinese scholar Li Zheng found a correlation between XRCC1‐399SNP and NSCLC through a genetic polymorphism study of BER in the Chinese population. Similarly, Korean scholar Kim found that XRCC1‐399SNP had an important role in the development of NSCLC through studying the 3 XRCC1 genetic sites in the Korean population. Nevertheless, foreign scholar Improta found no association between XRCC1‐399SNP and NSCLC through a polymorphism study of XRCC1 in a southern Italian population.…”

Section: Discussionmentioning

confidence: 97%

Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non‐small cell lung cancer in East Chinese Han population

Mei

et al. 2014

Clinical Respiratory J

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“…XRCC1 Arg399Gln, a functional genetic variation, may alter the capacity of XRCC1 to interact with several acting enzymes and associated with the efficiency of BER repair [24,25]. Many previous studies [26-28] revealed XRCC1 Arg399Gln was associated with the common cancers such as lung, bladder, esophageal cancers, etc. and modulated the cancer risk for common environmental exposure.…”

Section: Discussionmentioning

confidence: 99%

XRCC1 Arg399Gln was associated with repair capacity for DNA damage induced by occupational chromium exposure

Zhang

et al. 2012

BMC Res Notes

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BackgroundOccupational chromium exposure may induce DNA damage and lead to lung cancer and other work-related diseases. DNA repair gene polymorphisms, which may alter the efficiency of DNA repair, thus may contribute to genetic susceptibility of DNA damage. The aim of this study was to test the hypothesis that the genetic variations of 9 major DNA repair genes could modulate the hexavalent chromium (Cr (VI))-induced DNA damage.FindingsThe median (P25-P75) of Olive tail moment was 0.93 (0.58–1.79) for individuals carrying GG genotype of XRCC1 Arg399Gln (G/A), 0.73 (0.46–1.35) for GA heterozygote and 0.50 (0.43–0.93) for AA genotype. Significant difference was found among the subjects with three different genotypes (P = 0.048) after adjusting the confounding factors. The median of Olive tail moment of the subjects carrying A allele (the genotypes of AA and GA) was 0.66 (0.44–1.31), which was significantly lower than that of subjects with GG genotype (P = 0.043). The A allele conferred a significantly reduced risk of DNA damage with the OR of 0.39 (95% CI: 0.15–0.99, P = 0.048). No significant association was found between the XRCC1Arg194Trp, ERCC1 C8092A, ERCC5 His1104Asp, ERCC6 Gly399Asp, GSTP1 Ile105Val, OGG1 Ser326Cys, XPC Lys939Gln, XPD Lys751Gln and DNA damage.ConclusionThe polymorphism of Arg399Gln in XRCC1 was associated with the Cr (VI)- induced DNA damage. XRCC1 Arg399Gln may serve as a genetic biomarker of susceptibility for Cr (VI)- induced DNA damage.

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Polymorphisms and Haplotypes in the XRCC1 Gene and the Risk of Advanced Non-Small Cell Lung Cancer

Abstract: This study presents several novel aspects of the genetic susceptibility to develop NSCLC. Larger studies that will focus on the role of the rs1001581 and rs2293036 htSNPs and haplotypes for developing NSCLC are needed in the future.

Cited by 17 publications

References 38 publications

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non‐small cell lung cancer in East Chinese Han population

XRCC1 Arg399Gln was associated with repair capacity for DNA damage induced by occupational chromium exposure

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