Polymorphism Solvatomorphism 2008

Brittain, Harry G.

doi:10.1002/jps.21966

Cited by 33 publications

(22 citation statements)

References 179 publications

(177 reference statements)

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“…Various solvents used in the crystallization process and different melting points reported earlier, for example, 244°C–246°C,5,6 246°C–248°C,4 and 258°C,7 may indicate the existence of several crystal polymorphic or solvatomorphic forms of BA. Solvatomorphism can be defined as the ability of the compound to form several crystal unit cells, which differ in their structure and elemental composition due to the inclusions of solvent molecules 9,10. It is well known that different polymorphs or solvatomorphs exhibit significantly different pharmaceutically relevant properties such as solubility, stability, density, or bioavailability, particularly when the drug substance is poorly soluble 9–11…”

Section: Introductionmentioning

confidence: 99%

“…Solvatomorphism can be defined as the ability of the compound to form several crystal unit cells, which differ in their structure and elemental composition due to the inclusions of solvent molecules 9,10. It is well known that different polymorphs or solvatomorphs exhibit significantly different pharmaceutically relevant properties such as solubility, stability, density, or bioavailability, particularly when the drug substance is poorly soluble 9–11…”

Section: Introductionmentioning

confidence: 99%

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X-Ray Diffraction and Infrared Spectroscopy of N,N- Dimethylformamide and Dimethyl Sulfoxide Solvatomorphs of Betulonic Acid

Boryczka¹,

Jastrzębska²,

Bębenek³

et al. 2012

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

X-Ray Diffraction and Infrared Spectroscopy of N,N- Dimethylformamide and Dimethyl Sulfoxide Solvatomorphs of Betulonic Acid

Boryczka¹,

Jastrzębska²,

Bębenek³

et al. 2012

Journal of Pharmaceutical Sciences

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“…1 The presence of water in the compounds markedly alters their properties and behavior. 1 The presence of water in the compounds markedly alters their properties and behavior.…”

Section: Introductionmentioning

confidence: 99%

Assignment of the vibrational spectra of lithium hydroxide monohydrate, LiOH·H2O

Parker

Refson

Bewley

et al. 2011

The Journal of Chemical Physics

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The assignment of the vibrational spectra of lithium hydroxide monohydrate, LiOH·H(2)O, has been controversial for more than half-a-century. Here we show that only the combination of all three forms of vibrational spectroscopy: infrared, Raman and inelastic neutron scattering spectroscopies coupled with periodic-density functional theory calculations is able to satisfactorily assign the spectra. All previous work based on empirical criteria is, at least partially, incorrect. The librational modes of water do not follow the expected rock > wag > twist order and the calculations indicate that complete or partial deuterium substitution would not be useful in assigning the modes.

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“…[5][6][7][8][9] The present review continues the annual reviews of this field, will summarize works that have been published during 2010, with the papers and patents cited in the present review being drawn primarily from the major physical, crystallographic, and pharmaceutical journals. As always, the coverage cannot be represented as being totally comprehensive, and consequently apologies are offered in advance to any scientist whose works have been inadvertently omitted.…”

Section: Introductionmentioning

confidence: 99%