Polymorphism and Solvatomorphism 2010

Chemical and Physicochemical Approaches to Solve Formulation Problems

“…It has been estimated that as many as 80 percent of drug substances are polymorphic [28], echoing McCrone's famous claim that "It is at least this author's opinion that every compound has different polymorphs and that, in general, the number of forms known for a given compound is proportional to the time and money spent in research of that compound." Properties such as melting point, solubility, morphology, and surface free energy may differ [30]. Properties such as melting point, solubility, morphology, and surface free energy may differ [30].…”

FT-Raman Spectroscopy with Chemometric Methods for Quantification of Lamivudine Form II in Lamivudine Form I

“…It has been well known from the middle of 18 th century that many substances could be obtained in more than one crystalline form [1]. The subject of drug polymorphism has received extensive academic and industrial importance since the early pioneering reports of Aguiar et al [2,3], in which effect of polymorphism on dissolution and bioavailability were highlighted for the drug chloramphenicol palmitate.…”

Characterization and Physicochemical Evaluation of Molecular Complexes Formed Between Umifenovir and Dicarboxylic Acids

“…It is known that different polymorphs or pseudopolymorphs of pharmaceutical compounds may possess different chemical and physical properties which can affect the bioavailability and stability of the resulting drugs [1][2][3]. Crystalline form screening is a common procedure during the development of pharmaceutical molecules, and it is often possible to obtain drug candidates as many types of crystal forms, including salts, polymorphs, solvates (typically hydrates), and co-crystals [4].…”