Polymorphism rs4787951 in IL-4R contributes to the increased risk of renal cell carcinoma in a Chinese population

Lin, Yadi; Qi, Yuan; Qian, Fangze; Qin, Chao; Cao, Qiang; Wang, Meilin; Chu, Haiyan; Zhang, Zhengdong

doi:10.1016/j.gene.2018.11.070

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Similarly, the authors found that IL-13 rs2066960, rs2069744 had no relationship with the risk of renal cell carcinoma in another study. 30 Currently, research on the association between IL-13 and PTB was very limited, and our results contributed to further understanding of the role of IL-13 gene variation in the pathogenesis of PTB. It was important to noted that increased sample sizes and additional SNP might need to be explored.…”

Section: Discussionmentioning

confidence: 72%

Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis

Li¹,

Tang²,

Huang³

et al. 2022

JIR

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Our study aimed to explore the association of IL-13, IL-13RA1, and IL-13RA2 genes polymorphisms with PTB susceptibility and its clinical features. Methods: Nine SNPs were genotyped by improved multiple ligase detection reaction (iMLDR) in 476 PTB patients and 473 controls. The association between these SNPs and PTB risk was analyzed using SPSS software and haplotype analysis was assessed using SHEsis software. Results:The IL-13RA1 rs2495636 GA genotype frequency in PTB patients was significantly decreased, and IL-13RA2 rs5946039 A allele was related to the lower risk of PTB. In IL-13 gene, rs20541 variant was found to be associated with PTB risk under recessive mode. Moreover, IL-13RA1 rs141573089 C allele was significantly lower in PTB presenting with fever, drug resistance, and CC genotype was decreased in PTB presenting with leukopenia. IL-13RA1 rs2495636 polymorphism was associated with drug resistance, pulmonary infection, and IL-13RA2 rs3795175, rs638376 polymorphisms were related to drug resistance in PTB patients. Conclusion: IL-13 rs20541, IL-13RA1 rs2495636, IL-13RA2 rs5946039 polymorphisms might be contributed to the genetic background of PTB in Chinese population.

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Section: Discussionmentioning

confidence: 72%

Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis

Li¹,

Tang²,

Huang³

et al. 2022

JIR

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“…For instance, the IL-13 rs1800925 (C−1055T) polymorphism is adjacent to the nuclear factor of activated T cells (NFAT) binding site and some reports have indicated that it regulates IL-13 production (25)(26)(27)(28). Furthermore, IL-13 promoter polymorphism rs1881457 has been investigated for its association with renal cell carcinoma (29), coronary artery disease (30), lung cancer (31,32), and chronic obstructive pulmonary disease (33).…”

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confidence: 99%

Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility

Tsai

Chang

et al. 2020

Anticancer Res

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Background/Aim: The current study aimed at evaluating the contribution of IL-13 promoter rs1881457 and rs1800925 genotypes to the risk of breast cancer in Taiwan. Materials and Methods: A total of 1,232 breast cancer cases and 1,232 age-matched controls were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: As for IL-13 rs1881457, the rates of AA, AC and CC genotypes were 54.8, 37.9 and 7.3% among the cases, and 53.8, 38.7 and 7.5% among the healthy controls, respectively; there were no statistically significant differences between the two groups (p for trend=0.8889). Also, regarding IL-13 rs1800925, there were no statistically significant differences between the two groups either (p for trend=0.6803). Furthermore, the allelic frequencies for IL-13 rs1881457 and rs1800925 were not differentially distributed between the case and control groups (p=0.6515 and 0.8753, respectively). Conclusion: The rs1881457 and rs1800925 IL-13 promoter polymorphisms may not serve as breast cancer susceptibility determinants for Taiwanese.Breast cancer is the leading female malignant disease worldwide. In both genders combined in 2018, lung cancer was the most commonly diagnosed cancer (11.6% of the total cancer cases) and the leading cause of cancer-related death (18.4% of the total cancer deaths) followed by female breast cancer (11.6%) (1). Epidemiological studies indicate that breast cancer is caused by several environmental factors, including imbalanced diet, excessive alcohol drinking and cigarette smoking, and insufficient physical exercise (2, 3). In addition, genetic factors are also involved in breast cancer susceptibility, progression and prognosis (4-7).The gene of the immune-regulatory cytokine interleukin-13 (IL-13), cloned in 1993, is located on chromosome 5q31 and has a length of approximately 1.4 kb (8). The 13 kDa protein IL-13 is secreted predominantly by Th2 lymphocytes and natural killer T cells (9, 10). The role of IL-13 in tumor progression is complex, and it seems to function like a double-sided blade. Regarding tumor promotion, it has been previously reported that the decrease in IL-13 levels in CD1deficient mice lacking natural killer T cells may inhibit tumor recurrence (11-15). In addition, there is evidence that IL-13 may directly block apoptosis and promote proliferation of tumor cells in B chronic lymphocytic leukemia and Hodgkin disease (16)(17)(18)(19). Furthermore, a study has also indicated that CD4-positive T cell-derived IL-13 can 6743 *These Authors contributed equally to this study.

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The Prognosis Model of Clear Cell Renal Cell Carcinoma Based on Allograft Rejection Markers

Liu

Chen

Gopalakrishnan

et al. 2022

Intelligent Computing Theories and Application

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Polymorphism rs4787951 in IL-4R contributes to the increased risk of renal cell carcinoma in a Chinese population

Cited by 3 publications

References 36 publications

Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis

Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis

Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility

The Prognosis Model of Clear Cell Renal Cell Carcinoma Based on Allograft Rejection Markers

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