Polymorphism of vascular endothelial growth factor −1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case–control studies

Abstract

Published data on the association of vascular endothelial growth factor (VEGF) -1154G>A polymorphism with cancer risk is inconclusive. To derive a more precise estimation of association between VEGF -1154G>A polymorphism and the risk of cancer, we performed a meta-analysis of 7,071 cancer cases and 7,693 controls from 16 published case-control studies. Our meta-analysis didn't reveal an association between VEGF -1154G>A polymorphism and overall cancer risk (GG vs. AA: OR: 1.08, 95% CI: 0.96-1.20; GA vs. AA: OR: 1.04, 95% CI: 0.93-1.17; recessive model: GG+GA vs. AA: OR: 1.06, 95% CI: 0.95-1.18; dominant model: GG vs. GA+AA, OR: 1.11, 95% CI: 1.00-1.24). Nevertheless, for non-Caucasians, GG homozygote may have higher cancer risk compared with either A carriers (OR: 1.58, 95% CI: 1.12-2.23) or AA homozygote (OR: 1.43, 95% CI: 1.17-1.76). No significant heterogeneity was detected except in the dominant model and "prostate cancer" subgroup analysis. More studies with larger samples are warranted to confirm these findings.

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

“…The previous metaanalyses performed by Xu et al, 35 Hong et al, 36 and Liu et al 37 contained one study related to OC; those by Cao et al 38 and Hong et al 39 included 2 studies that tested OC. None of these 5 meta-analyses focused exclusively on OC, and none of them conducted subgroup analysis for OC.…”

Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity

“…VEGFA is a highly polymorphic gene with more than 20 reported potential functional SNPs in cancer risk association studies. Some widely studied SNPs, i.e., −2578C/A (rs699947), −2,549 insertion/deletion polymorphism, −460C/T (rs833061), −1154G/A (rs1570360), −634C/G (rs2010963), +936C/T (rs3025039), +1612G/A (rs10434), are reported to be associated with multiple cancers but with controversial results . On the other hand, there are only a few studies concerning HCC risk and VEGFA polymorphisms, with small sample size and limited polymorphisms studied.…”

Associations between single‐nucleotide polymorphisms of the VEGF gene and long‐term prognosis of oral squamous cell carcinoma

“…It was prior indicated that alterations in VEGF expressions and/or functions, that are also described in cases of VEGF‐SNPs , may predict alterations in metastasis rate, treatment response, and progression‐free survival in different malignancies . It was mentioned that VEGF polymorphisms may influence cancer progression rather than the development of malignancies . Therefore, in a retrospective clinical long‐term setting, possible associations between five functional VEGF polymorphisms and prognostic long‐term data in OSCC patients were evaluated.…”