Associations between single‐nucleotide polymorphisms of the VEGF gene and long‐term prognosis of oral squamous cell carcinoma

Kämmerer, Peer W.; Koch, Felix P.; Schiegnitz, Eik; Kumar, Vijaya; Berres, Manfred; Toyoshima, Takeshi; Brieger, Jürgen

doi:10.1111/jop.12026

Cited by 18 publications

(27 citation statements)

References 51 publications

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“…In addition, the +936 CC genotype was associated with advanced OSCC in the study by Supic et al (20). An additional European study did not identify any association of the +936 C/T polymorphism with OSCC (19). Two Asian studies suggested SNP -460 C/T as a suitable genetic marker of OSCC (21,25), whereas in a European study no such association was observed (19), indicating an effect of the origin of the subjects.…”

Section: Search Resultsmentioning

confidence: 74%

“…An additional European study did not identify any association of the +936 C/T polymorphism with OSCC (19). Two Asian studies suggested SNP -460 C/T as a suitable genetic marker of OSCC (21,25), whereas in a European study no such association was observed (19), indicating an effect of the origin of the subjects. Kämmerer et al (19) identified the -405 GG genotype as a biomarker for poor survival in advanced OSCC.…”

Section: Search Resultsmentioning

confidence: 93%

“…Two Asian studies suggested SNP -460 C/T as a suitable genetic marker of OSCC (21,25), whereas in a European study no such association was observed (19), indicating an effect of the origin of the subjects. Kämmerer et al (19) identified the -405 GG genotype as a biomarker for poor survival in advanced OSCC. Supic et al (20) reported decreased overall survival associated with SNP -1154 GG, suggesting a consideration of this SNP as a prognostic marker of poor survival in advanced-stage OSCC patients.…”

Section: Search Resultsmentioning

confidence: 99%

“…Supic et al (20) reported decreased overall survival associated with SNP -1154 GG, suggesting a consideration of this SNP as a prognostic marker of poor survival in advanced-stage OSCC patients. Kämmerer et al (19) observed a worse overall and disease-free survival for advanced OSCC associated with the -1154 AA genotype. Despite the differences attributed to genetic background, environmental factors such as smoking or alcohol consumption were proven to be the main risk factors for the development of OSCC.…”

Section: Search Resultsmentioning

confidence: 99%

“…A possible association of smoking and VEGF-SNPs with the incidence of OSCC was investigated in single studies comprising only small samples. In brief, five common VEGF-SNPs in the 5'-untranslated promoter region [-2578 C/A, -460 C/T, +405 C/G (also referred to as -634 G/C) and -1154 G/A] or the 3'-untranslated region (+936 C/T) and their association with OSCC were analysed (6,(19)(20)(21)(22). Studies investigating VEGF-SNPs and their correlation with OSCC were reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: A systematic review and meta-analysis

Metzger

Kämmerer

Schmidtmann

et al. 2014

Molecular and Clinical Oncology

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Abstract.Smoking is one of the main risk factors for the development of oral squamous cell carcinoma (OSCC). Smoking may affect single-nucleotide polymorphism (SNP)-dependent vascular endothelial growth factor (VEGF)-induced angiogenic activity. Therefore, we systematically reviewed the published VEGF-SNP genotype data of OSCC patients and healthy individuals and performed a meta-analysis comparing the VEGF-SNP genotypes of smoking and non-smoking patients in association with OSCC incidence. Prospective and retrospective studies on the clinical comparison of OSCC patients with different VEGF-SNP genotypes were reviewed. The meta-analysis re-pooled studies of smoking and non-smoking OSCC patients with different VEGF-SNPs between 2006 and 2014. The identified articles were reviewed and those reporting pertinent information, assignment to smoking and non-smoking patient groups and sufficient data for estimation of an odds ratio (OR) with a 95% confidence interval (CI) were selected for the meta-analysis. Pooled ORs and CIs for the comparison of SNP distribution in the smoking and non-smoking subgroups were calculated and compared using the random-effects model. A total of 7 studies were included in the systematic review, which was followed by a meta-analysis using 3 pertinent studies. The reviewed studies reported discrepant findings, with differences between Asian and European patients. The meta-analysis demonstrated marginal but not statistically significant differences, suggesting that specific VEGF-SNPs may be OSCC risk modifiers for smokers, depending on the ethnic background. The performed meta-analysis suggested an increased OSCC risk for smokers carrying specific VEGF-genotypes, although the calculated data did not reach the level of significance. However, data have to be interpreted with caution due to the limited sample size. Therefore, further studies, including larger patient samples, are mandatory.

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Section: Search Resultsmentioning

confidence: 74%

Section: Search Resultsmentioning

confidence: 93%

Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: A systematic review and meta-analysis

Metzger

Kämmerer

Schmidtmann

et al. 2014

Molecular and Clinical Oncology

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Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer

2017

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Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo

Zhang

Cheng

et al. 2017

Molecular Carcinogenesis

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Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by the time it is diagnosed, high recurrence rates and metastasis. In the present study, we investigated the effects of metformin (a safe anti-diabetic drug) and curcumin (a turmeric polyphenol extracted from rhizome of Curcuma longa Linn.) on proliferation, apoptosis, invasion, metastasis, and angiogenesis of HCC in vitro and in Conventional chemotherapy remains ineffective in curing HCC due to its high hepatotoxicity. Natural dietary phytochemicals could be potential options of cancer therapy for reducing adverse side effects and improving the anti-cancer effectiveness. 5 Curcumin is a turmeric polyphenol extracted from rhizome of Curcuma longa Linn. Curcumin has pleiotropic pharmacological effects, good tolerance and low toxicity 6 and has been reported to have anti-tumor effects in numerous cancers, including HCC. 7 Metformin is a well-tolerated anti-diabetic drug and has been reported to reduce the risk of various cancers including HCC. 8 Recently, clinical evaluation of metformin for its chemo-preventive and antineoplastic effects has bypassed the traditional phase I 44 |

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Associations between single‐nucleotide polymorphisms of the VEGF gene and long‐term prognosis of oral squamous cell carcinoma

Abstract: Possible reciprocal interactions between smoking and VEGF-SNP function were observed. Multivariate analysis confirmed the VEGF +405 G/G genotype to be associated with poor survival in advanced OSCCs; a further use of this haplotype as biomarker has to be discussed.

Cited by 18 publications

References 51 publications

Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: A systematic review and meta-analysis

Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: A systematic review and meta-analysis

Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer

Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo

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