Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Martı́nez-Laso, Jorge; Herráiz, M.; Vidart, José Antonio; Peñaloza, J.; Barbolla, Maria Luz; Jurado, María; Cervera, Isabel

doi:10.1016/j.humimm.2011.02.013

Cited by 5 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 The aforementioned data indicate that HLA-B15 is found in various different ethnic groups, crossing geographical barriers, and altogether these data further support the notion that HLA-B15 plays a role in SpA pathogenesis. 44 …”

Section: Discussionmentioning

confidence: 99%

“…HLA-B15 is an MHC class I molecule encoded by multiple polymorphic alleles leading to at least 7 serological subtypes. 44 Variants have been described—with either tyrosine or serine at position 116—that greatly diverge in their interaction (either strong or weak, respectively) with other proteins in the endoplasmic reticulum for antigen presentation at the cell surface. 47 Accordingly, it might be expected that genetic diversity can contribute to increased or decreased predisposition to autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

et al. 2015

View full text Add to dashboard Cite

ObjectiveHuman leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between SpA with axial and peripheral patterns. We analysed whether HLA-A, HLA-B and HLA-DRB1 alleles could associate with these patterns.MethodsWe studied 100 healthy individuals and 178 patients with SpA according to European Spondyloarthropathy Study Group (ESSG) criteria. Patients were then classified according to ASAS criteria, the axial spondyloarthritis pattern (axSpA) being defined by ascertained sacroiliitis and the peripheral pattern (pSpA) by enthesitis and/or arthritis in extremities. A combined ax/p pattern was also considered.ResultsOnly HLA-B27 and HLA-B15 alleles were associated with SpA. ASAS criteria for axSpA were met in 152 patients (12 with isolated axSpA and 140 with a combined ax/p patterns). When the ASAS peripheral criteria were applied, 161 patients met these criteria (13 with isolated pSpA and 148 with a combined ax/p pattern). HLA-B27 was found in 83% of patients with axSpA and 43% of ax/pSpA patients according to axASAS. HLA-B27 occurred in 7% controls but not in any patient with isolated pSpA. HLA-B15 was encountered in 31% of patients with isolated pSpA and 20% of ax/pSpA patients according to pASAS criteria. Moreover, 2 healthy controls, but none of our patients with isolated axSpA were positive for HLA-B15.ConclusionsOur data suggest that the presence of HLA-B15 favours the development of isolated/combined peripheral rather than isolated axSpA, while HLA-B27 promotes an isolated/combined axial disease and excludes a peripheral pattern. HLA-B15 should be considered in addition to HLA-B27 when diagnosing patients with SpA according to ASAS criteria.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The latter has certain characteristics of the A9 (last part of introns 3, 5, and 7) and A2 family alleles (intron 6) (Figures 1 and 2). There are a lot of data supporting the idea that intron sequences give a more clear view of the evolutionary pathways of the HLA alleles generation than the exon sequences (22)(23)(24). These data confirm that intron sequences are coming from a recombination from to HLA-A ancestral sequences belonging to A2 and A3 families, respectively, followed by an evolutionary pressure mainly in exons 2 and 3 with point mutations, and other recombination events as cross-linking or gene conversion events with the surrounding alleles.…”

Section: Figure 2 Continuedmentioning

confidence: 99%

Different patterns of A80:01:01:01* allele generation based on exon or intron sequences

et al. 2014

View full text Add to dashboard Cite

Generation of the HLA-A*80:01:01:01 allele has been analysed using its complete sequence. Direct comparison of the sequences and phylogenetic trees using the human leukocyte antigen (HLA)-A representative alleles and the major histocompatibility complex (MHC)-A sequences of non-human primates has been made. Results based on exon sequences confirm previously published, but considering only the sequences of the introns, two distinct regions can be differentiated. The first one comprises from the 5' untranslated region region to the first part of intron 3 sequence (shared with A2 family), and the second one includes the sequence from the end of intron 3 to intron 7 (shared with A1/A3/A11/A36/A30 family). Each of them clusters with Gorilla and Chimpanzee MHC-A sequences, respectively, suggesting an origin coming from a common ancestor to Gorilla and Chimpanzee.

show abstract

“…The number of identified HLA alleles has grown rapidly, and 9946 alleles for HLA loci have been identified according to the IMGT/HLA database release 3.14.0, including 3086 HLA‐B alleles . Most polymorphisms of HLA‐B locus are presented in the exons 2, 3 and 4, but in recent years some new HLA‐B alleles have been identified because of nucleotide changes in other exons and introns .…”

mentioning

confidence: 99%

Genomic full‐length sequence of a novel HLA‐B39:01:01:03* allele was identified in a Chinese individual

Chen

Zhang

et al. 2013

Tissue Antigens

View full text Add to dashboard Cite

show abstract

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Cited by 5 publications

References 36 publications

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

Different patterns of A80:01:01:01* allele generation based on exon or intron sequences

Genomic full‐length sequence of a novel HLA‐B39:01:01:03* allele was identified in a Chinese individual

Contact Info

Product

Resources

About

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Cited by 5 publications

References 36 publications

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns

Different patterns of A*80:01:01:01 allele generation based on exon or intron sequences

Genomic full‐length sequence of a novel HLA‐B*39:01:01:03 allele was identified in a Chinese individual

Contact Info

Product

Resources

About

Different patterns of A80:01:01:01* allele generation based on exon or intron sequences

Genomic full‐length sequence of a novel HLA‐B39:01:01:03* allele was identified in a Chinese individual