Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries

Borinskaya, S. A.; Kal'ina, Nina; Sanina, E. D.; Kozhekbaeva, Zh. M.; Gupalo, E. Yu.; Гармаш, И. В.; Ogurtsov, Pavel; Parshukova, O N; Bojko, S. G.; Veselovsky, E. M.; Vershubskaya, Galina; Козлов, А. И.; Rogaev, Evgeny I.; Yankovsky, N. K.

doi:10.1134/s1022795407100158

Cited by 12 publications

(13 citation statements)

References 24 publications

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“…In Uygur population, the frequencies of the E2, E3, and E4 were found to be 15%, 64%, and 19% and in Han population, those ratios were 8%, 77%, 14% respectively (25). The frequencies of alleles E3 and E4 were similar in Russia and neighboring countries (26).…”

Section: Allele Frequenciesmentioning

confidence: 77%

Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism

Ince

Köseoğlu²,

Yeşìl³

et al. 2010

Anadolu Kardiyol Derg

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Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism Results: The genotype frequencies were 7.5% for E2/E3, 77.4% for E3/E3 and 15.1% for E3/E4. The E2 allele frequency was slightly lower than E4 allele. There were no significant differences between apo E2/E3, E3/E3 and E3/E4 genotypes for severity scorings (26, 41 and 32 respectively, p=0.30) and extent scorings (3.2, 5.5, 4.5, p=0.17). It was found that the most of patients who had E2/3 and E3/4 alleles had low severity scores. On the other hand, there were no significant score difference for patients who had E3/3 alleles. Lipids were not significantly different among the different genotypes. The E3 allele was associated with high apo B levels compared with E2 and E4 genotypes. It was found that severity and extent of disease were not related with lipid metabolism. Conclusion: We concluded that there were no statistically significant differences between genotypes for extent and severity scorings, but the apo E3 allele is associated with more severe disease than E2 allele. These associations with severity were mediated not only by changes in lipid metabolism but may be also by other mechanisms in CAD patients. (Anadolu Kardiyol Derg 2010; 10: 202-8)

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Section: Allele Frequenciesmentioning

confidence: 77%

Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism

Ince

Köseoğlu²,

Yeşìl³

et al. 2010

Anadolu Kardiyol Derg

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“…In different Komi groups, the occur rence of allele *ε4 varies from 0.13 to 0.22; these values are higher average frequencies typical of groups of European inhabitants [9,28]. Serum CH LDLP was shown to be increased in subjects with allele APOE*ε4 [29,30].…”

Section: Discussionmentioning

confidence: 99%

Blood serum concentration of lipids and lipoproteins and body composition

et al. 2012

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The goal of this study was to analyze the relationship of the blood serum apolipoprotein E (apoE), total cholesterol (TC), triglycerides (TG), and high and low density lipoproteins (HDLP, LDLP) levels with the body mass index (BMI), relative body surface area (RBSA), and the body muscle (BM) and body fat (BF) amounts. The study was carried out in male and female subjects aged 14-16 years (adolescent age group 1: n 1 M = 141, n 1 F = 151) and 18-25 years (young adult group 2: n 2 M = 141, n 2 F =46). No significant correla tions of serum TG and HDL with the somatometric indices were found. The TÑ content is positively corre lated with the fat component (r 1 = 0.164; r 2 = 0.418) and negatively, with the muscle component of body com position (r 1 = -0.165; r 2 = -0.352) in female subject samples. Blood serum apoE is significantly correlated with body composition (r 1 = -0.168 for BF; r 1 = 0.266, p < 0.05 for BM) in female adolescent subjects. These correlations are significant (p < 0.06) in male subjects aged 14-16 years. The TC and LDLP contents are neg atively correlated with RBSA (r 2 = -0.386 and -0.377, respectively) and positively correlated with BMI (r 2 = 0.413 and 0.415, respectively; p < 0.05) in young adult female subjects. With age, correlations between the fat content and apoE concentration change in female subject samples. The content of apoE decreases with increasing BF in female subjects aged 14-15 years; the correlation disappears in the age interval from 16 to 17 years. An increase in BF is accompanied by an increase in the apoE concentration in female subjects aged 18-19 years and older.

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“…In the various groups of the Komi, the frequency of this allele varies within 13-22%; in the Mari, its frequency is 15%; and only in Mordvinians is it reduced to a European medium of 10% (Borinskaya et al, 2007). We have analyzed the evolutionary and historical reasons for this in a num ber of works (Borinskaya et al, 2009;Kozlov et al, 2008;Kozlov and Sanina et al, 2009).…”

Section: Data: Analysis and Interpretationmentioning

confidence: 94%

“…Thus, a very high frequency of this allele (40%) was detected in hunter gatherers of tropical regions of Africa and South America (Lehtinen et al, 1994;Eisenberg et al, 2010), and a very high one (20%) in the Chukchi Arc tic natives, who are close to the hunter gatherers on the food composition (Kozlov, 2005;Borinskaya et al, 2007). On this basis, we can assume that the high fre quency of the thrifty allele offers certain advantages in the way of life of hunter gatherers or Arctic reindeer herders.…”

Section: Introductionmentioning

confidence: 96%

“…As a result, the odds ratio of peripheral vascular lesions and early development of atherosclerosis and coronary heart disease in carriers of *ε2 allele compared with carriers of the genotype *ε/*ε3 is greater than 1: OR = 1.11 1.25 1.43 , where the average is a point estimate of the odds ratios and the boundary is the upper and lower boundaries of the 95% confidence interval (Bennet et al, 2007). *ε3 is the most common allele; in different groups, the share of its carriers is 50-90% (Borinskaya et al, 2007;Eisenberg et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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The APOE gene ɛ4/ɛ4 “thrifty genotype” and risk of metabolic disorders in populations of the Ural region

Козлов

Borinskaya

Sanina

2012

Russ J Genet Appl Res

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The prevalence of APOE gene ε4/ε4 genotype and its possible contribution to the incidence of cir culatory system diseases in groups with varying degrees of "westernization" are under the consideration. It is proposed that the populations undergoing "modernization transition" with a high frequency of *ε4 carriers are in the most vulnerable position. These are Eastern Finns and especially indigenous peoples of the North, who have a higher incidence of circulatory system diseases than do residents of large cities.

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Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries

Cited by 12 publications

References 24 publications

Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism

Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism

Blood serum concentration of lipids and lipoproteins and body composition

The APOE gene ɛ4/ɛ4 “thrifty genotype” and risk of metabolic disorders in populations of the Ural region

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