Blood serum concentration of lipids and lipoproteins and body composition

Abstract

The goal of this study was to analyze the relationship of the blood serum apolipoprotein E (apoE), total cholesterol (TC), triglycerides (TG), and high and low density lipoproteins (HDLP, LDLP) levels with the body mass index (BMI), relative body surface area (RBSA), and the body muscle (BM) and body fat (BF) amounts. The study was carried out in male and female subjects aged 14-16 years (adolescent age group 1: n 1 M = 141, n 1 F = 151) and 18-25 years (young adult group 2: n 2 M = 141, n 2 F =46). No significant correla tions of serum TG and HDL with the somatometric indices were found. The TÑ content is positively corre lated with the fat component (r 1 = 0.164; r 2 = 0.418) and negatively, with the muscle component of body com position (r 1 = -0.165; r 2 = -0.352) in female subject samples. Blood serum apoE is significantly correlated with body composition (r 1 = -0.168 for BF; r 1 = 0.266, p < 0.05 for BM) in female adolescent subjects. These correlations are significant (p < 0.06) in male subjects aged 14-16 years. The TC and LDLP contents are neg atively correlated with RBSA (r 2 = -0.386 and -0.377, respectively) and positively correlated with BMI (r 2 = 0.413 and 0.415, respectively; p < 0.05) in young adult female subjects. With age, correlations between the fat content and apoE concentration change in female subject samples. The content of apoE decreases with increasing BF in female subjects aged 14-15 years; the correlation disappears in the age interval from 16 to 17 years. An increase in BF is accompanied by an increase in the apoE concentration in female subjects aged 18-19 years and older.

Improvements in metabolic abnormalities among overweight schizophrenia and bipolar disorder patients

“…Based on multivariate linear regression modeling, factors associated significantly and independently with serum lipid concentrations and their decreases during six-months of follow-up included higher BMI, older current age, and diagnosis of BD (Table 3), whereas higher serum lipid and glucose concentrations with older age would be expected [17,28,29]. As already noted, the association of obesity with BD may reflect risks associated with the disorder itself, with its often complex and sometimes unsatisfactory treatment, or, very likely, both [5,7,11,24].…”

Acute toxicity of nickel nanoparticles in rats after intravenous injection

“…Apart from lipid metabolism, the Apo-E protein is thought to have a variety of functions, such as repairing blood vessel walls, regulation of immune status, and anti-oxidant activities. 28 The increase in serum levels of Apo-E in this study may have been in response to the increase in cholesterol levels. It may also have been increased in response to other factors, such as oxidative stress, mechanical stress on the blood vessel walls due to the type of exposure mode used (intravenous), and immune response.…”

Vitamin D Deficiency

“…According to A.I. Kozlov et al, low calcidiol concentration (below 50 nmol/l) was observed in 47% of the examined adolescents in the Perm Territory; deficient concentration of vitamin D was observed in 86% of the girls and boys in the Komi Republic in autumn and in 98% -in the early spring [25]. Thus, analysis of the level of children's and adolescent's provision with vitamin D in various climate/geographic regions of Russia indicates its differences and appears extremely important.…”