Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer

Grešner, Peter; Gromadzińska, Jolanta; Wąsowicz, Wojciech

doi:10.1016/j.lungcan.2007.02.002

Cited by 58 publications

(45 citation statements)

References 194 publications

(267 reference statements)

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“…NRF2 regulates the expression of several genes encoding antioxidant and detoxification proteins or enzymes (11,25). Differences in the xenobiotic metabolism may contribute to the risk of developing both CODP and lung cancer (26,27). Common somatic mutations in the encoding region of the NRF2 gene resulting in increased cellular accumulation of NRF2 are associated with poor prognosis in squamous cell lung carcinoma (27,28).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers

et al. 2013

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Abstract. The metabolism of xenobiotics plays a fundamental role in smoking-related lung function loss and the development of pulmonary disease. An NRF2-dependent response is a key protective mechanism against oxidative stress. In the present study, we evaluated the effect of single nucleotide polymorphisms in NRF2 genes on the level of forced expiratory volume in one second (FEV1) in lung cancers of smokers. We genotyped the status of NRF2 gene polymorphisms in 209 surgically treated lung cancer cases of smokers using TaqMan polymerase chain reaction (PCR). The results demonstrated the mean FEV1 in patients with

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers

et al. 2013

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“…The genetic variations of carcinogen-metabolizing enzymes may lead to interindividual differences in the levels of the internal carcinogenic dose and lead to a differential risk in individuals with similar exposures [1,2] . Phase I enzymes such as myeloperoxidase (MPO) and cytochrome P450 can metabolically activate a wide range of tobacco mutagens to DNAdamaging metabolites [3,4] .…”

Section: Introductionmentioning

confidence: 99%

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

Feng

Mei

et al. 2014

Acta Pharmacol Sin

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Aim: Myeloperoxidase (MPO) and glutathione S-transferase pi 1 (GSTP1) are important carcinogen-metabolizing enzymes. The aim of this study was to investigate the association between the common polymorphisms of MPO and GSTP1 genes and lung cancer risk in Chinese Han population. Methods: A total of 266 subjects with lung cancer and 307 controls without personal history of the disease were recruited in this case control study. The tagSNPs approach was used to assess the common polymorphisms of MOP and GSTP1 genes and lung cancer risk according to the disequilibrium information from the HapMap project. The tagSNP rs7208693 was selected as the polymorphism site for MPO, while the haplotype-tagging SNPs rs1695, rs4891, rs762803 and rs749174 were selected as the polymorphism sites for GSTP1. The gene polymorphisms were confirmed using real-time PCR, cloning and sequencing. Results: The four GSTP1 haplotype-tagging SNPs rs1695, rs4891, rs762803 and rs749174, but not the MPO tagSNP rs7208693, exhibited an association with lung cancer susceptibility in smokers in the overall population and in the studied subgroups. When Phase 2 software was used to reconstruct the haplotype for GSTP1, the haplotype CACA (rs749174+rs1695 + rs762803+rs4891) exhibited an increased risk of lung cancer among smokers (adjust odds ratio 1.53; 95%CI 1. 04-2.25, P=0.033). Furthermore, diplotype analyses demonstrated that the significant association between the risk haplotype and lung cancer. The risk haplotypes co-segregated with one or more biologically functional polymorphisms and corresponded to a recessive inheritance model. Conclusion: The common polymorphisms of the GSTP1 gene may be the candidates for SNP markers for lung cancer susceptibility in Chinese Han population.

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“…With the improvement in molecular biotechnology, more and more genes associated with genetic susceptibility to lung cancer have been found. Most of them are DNA repair genes (such as OGG1, XRCC1 and APEX1) and biotransformation genes (such as CYP1 gene family and EPHX1 gene) (Kiyohara et al, 2006;Gresner et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Yang¹,

Wang²,

Shi³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

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Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer

Cited by 58 publications

References 194 publications

Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers

Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

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