Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Abstract

ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>

“…Lower frequency of HLA-DRB1*1302 was found in Han nationality lung cancer patients from North China and it was also detected in Japanese lung cancer patients 33,34. And patients of Han nationality from North China had higher frequency of HLA-DRB1*0401, HLA-DRB1*0402 and HLA-DRB1*1201 than healthy controls, which might indicate that these were susceptible factors of lung cancer 33. In Japanese, HLA-DRB1*14 group was found absent in lung cancer patients while the frequency of HLA-DRB1*0901 was significantly increased 34…”

“…For instance, HLA-DRB1*1301/02 frequency was lower in patients compared to that in control, while HLA-DQB1*03 frequency was higher in HPV (+) cervical carcinoma 32. Lower frequency of HLA-DRB1*1302 was found in Han nationality lung cancer patients from North China and it was also detected in Japanese lung cancer patients 33,34. And patients of Han nationality from North China had higher frequency of HLA-DRB1*0401, HLA-DRB1*0402 and HLA-DRB1*1201 than healthy controls, which might indicate that these were susceptible factors of lung cancer 33.…”

“…As many studies have shown HLA class II gene is different between cancer patients and healthy controls, HLA class II gene analysis may provide predictive information for lung cancer risk, prognosis and response to treatment 33,38,42. However, HLA genes have intrinsic differences between different regions and nationalities, which makes it necessary to do further research in large NSCLC samples in different regions and nationalities.…”

Comparative beneficiary effects of immunotherapy against chemotherapy in patients with advanced NSCLC: Meta-analysis and systematic review

“…MCP-1 is known to be a tumor suppressor via pathways involving T-lymphocytes or independent of lymphocytes (14). Similarly, we also noted that the frequencies of polymorphisms in the human leukocyte antigen (HLA) system, which is involved in the regulation of immune response, HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 are higher in the lung cancer patients than healthy controls (15), and affect the tumor immunity.…”

Network Pharmacology Approach Reveals the Potential Immune Function Activation and Tumor Cell Apoptosis Promotion of Xia Qi Decoction in Lung Cancer

“…While complexing with antigenic peptides, HLA-B molecules initiate CD8+T cell responses via interaction with the T cell receptor (TCR) and coreceptor CD8 [68]. Similarly, the expression of HLA-B in cancer cells was helpful in activating the activation and proliferation of CD8+T cells [69].…”