Network Pharmacology Approach Reveals the Potential Immune Function Activation and Tumor Cell Apoptosis Promotion of Xia Qi Decoction in Lung Cancer

Zhang, Song; Wang, Yun

doi:10.3390/medsci8010001

Cited by 5 publications

(3 citation statements)

References 80 publications

(81 reference statements)

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“…Treatment of hyperlipidemic postmenopausal women in China with genistein (60 mg/day) for six months signifcantly lowered TC, TG, and LDL cholesterol levels, while HDL cholesterol levels as well as mRNA expression and protein levels of LDLR, and liver X receptor α (LXRα) were markedly increased [56]. Te efects of genistein on lipids profle are shown in Table 3.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Pharmacological Effects of Genistein on Cardiovascular Diseases

Jafari,

Shoghi,

Khazdair

2023

Evidence-Based Complementary and Alternative Medicine

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Cardiovascular diseases (CVDs) are a group of disorders that involve the heart or blood vessels and are the leading cause of mortality worldwide. Natural products have several pharmacological activities, such as anti-inflammatory, antioxidant, and immunoregulatory properties. This review summarizes the possible therapeutic effects of Genistein on CVD. The information from the current review study was obtained by searching for the keywords such as “Genistein”, “Cardiac dysfunction”, “hypertrophy”, and “Ischemia” “lipid profile” in different online database such as PubMed, Scopus, and Google Scholar, until February 2022. The results of the studies showed that genistein intake has a promising effect on improving cardiac dysfunction, ischemia, and reperfusion of the heart, decreasing cardiac toxicity, modulating lipid profile, and lowering blood pressure. The preventive effects of genistein on experimental models of studies were shown through mechanisms such as anti-inflammatory, antioxidant, and immunomodulatory effects. Pharmacological effects of genistein on cardiac dysfunction, cardiac toxicity, lipid profile, and hypertension indicate the possible remedy effect of this agent in the treatment of CVD.

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Section: In Vivo Studiesmentioning

confidence: 99%

Pharmacological Effects of Genistein on Cardiovascular Diseases

Jafari,

Shoghi,

Khazdair

2023

Evidence-Based Complementary and Alternative Medicine

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“…In a similar way, natural products and NP approaches are being used to discover new agents or indicate new combinations to improve current therapies [98,99]. Multitarget natural dietary supplements containing some ingredients such as Ginseng extracts, Grape seed extracts, and curcumin have been shown to promote recovery from se-vere illnesses, and relieve standard therapy-induced side effects [100].…”

Section: Network Pharmacology In Cancermentioning

confidence: 99%

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Gomez-Cadena¹,

Barreto²,

Fioretino³

et al. 2020

CST

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Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments. However, a promising field in the current therapies based on plant-derived compounds is the study of their immunomodulation properties and their capacity to activate the immune system to fight against multifactorial diseases like cancer. In this review we discuss how network pharmacology could help to characterize and validate natural single molecules or more complex preparations as promising cancer therapies based on their multitarget capacities.

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“…Traditional Chinese medicine (TCM) with antitumor effects has become an important part of clinical prescriptions of TCM and the source of new antitumor drug development [3]. Rhizoma Curcumae, known as Ezhu in China, is a plant of Curcuma L of Zingiberaceae, from dried roots of Curcuma phaeocaulis, Curcuma kwangsiensis, and Curcuma wenyujin.…”

Section: Introductionmentioning

confidence: 99%

Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology

Zhai

Huang

Liao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Aim. To analyse the target of Rhizoma Curcumae in nasopharyngeal carcinoma by using network pharmacological techniques and to explore the associated molecular mechanism. Methods. The targets of nasopharyngeal carcinoma were retrieved from the GeneCards database. At the same time, the drug therapeutic targets of Rhizoma Curcumae were obtained from the TCMSP and SymMap databases. The data were imported into the STRING database and Cytoscape 3.7.1 to construct a network of “Chinese medicine component-target-disease” interactions; then, the intersection was screened as the core Rhizoma Curcumae antinasopharyngeal cancer targets. Through GO target function and KEGG pathway enrichment analyses of the core targets, we predicted the biological processes and key signalling pathways involved in the Rhizoma Curcumae treatment of nasopharyngeal carcinoma. Results. Twenty-five core targets of Rhizoma Curcumae in nasopharyngeal carcinoma were mined: TP53, BCL2 ICAM1 RXRA, TLR3 and TLR9, TNF, PTGS2, IL-6, CTSD, MMP2, MMP9, MMP14, TIMP2, ABCC1, ABCB1, ABCG2, and so on. The results of visual analysis showed that the Rhizoma Curcumae treatment of nasopharyngeal carcinoma mainly involves leukocyte adhesion to vascular endothelial cells, positive regulation of NF-κB import into the nucleus, regulation of the reactive oxygen species biosynthetic and metabolic process, regulation of the chemokine biosynthetic and metabolic process, various cancer-related signalling pathways, and a variety of cytokine signal transduction pathways, such as the NF-κB, TLR, IL-17, and TNF signalling pathways. Conclusion. The core targets predicted by our research can be used as molecular markers for the treatment and prediction of nasopharyngeal carcinoma. The mechanism of Rhizoma Curcumae treatment in NPC may be related to immune regulatory pathways, the inhibition of cancer cell proliferation, metastasis, and angiogenesis, as well as the regulation of tumour microenvironment. Combined with the prediction of its associated mechanism of action, the core targets can provide targeted reference value for subsequent drug development related to Curcuma.

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Network Pharmacology Approach Reveals the Potential Immune Function Activation and Tumor Cell Apoptosis Promotion of Xia Qi Decoction in Lung Cancer

Cited by 5 publications

References 80 publications

Pharmacological Effects of Genistein on Cardiovascular Diseases

Pharmacological Effects of Genistein on Cardiovascular Diseases

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology

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