Polymorphism of genes of methylenetetrahydrofolate reductase, glutathione S-transferase P1 and M1, cytochrome P450 1A1 and glutathione S-transferase activity in human placenta

Abstract

For the first time the prevalence of Ñ677Ò methylenetetrahydrofolate reductase (MTHFR) genotypes was detected in a cohort of Ukrainian population. We have analyzed the association of polymorphism of MTHFR alone and in its combination with polymorphic genes coding for glutathione S-transferase P1, glutathione S-transferase M1, and cytochrome P450 1A1 with cytosolic glutathione S-transferase activity in human placenta samples. The substitution of Ñ677÷Ò677 in at least one allele of MTHFR gene is accompanied by the tendency of GST activity to increase. The tendency remains irrespective of allelic variants of other three genes in specified combinations. The possible relation between the MTHFR allelic variants and cytosolic glutathione S-transferase activity is discussed.