Polymorphism of genes for catechol-O-methyltransferase (COMT) and hemochromatosis (HFE) in residents of radiocontaminated regions varying in chromosome aberration frequency

Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma

“…The 389 bp fragment of the HFE gene including codon Cys282Tyr was amplified with primers F 5′-TGGCAAGGGTAAACAGATCC and R 5′-CTCAGGCACTCCTCTCAACC; the 208 bp fragment of the HFE gene containing codon His63Asp was amplified using primers F 5′-ACATGGTTAAGGCCTGTTGC and R 5′-GCCACATCTGGCTTGAAATT. Primers used to amplify a 169 bp of the COMT gene containing codon Val158Met were F 5′-ACTGTGGCTACTCAGCTGTG and R 5′-CCTTTTTCCAGGTCTGACAA [ 15 ]. The fragments were amplified in 25 μ L reaction volume containing 0,625 U of HotStarTag polymerase (Qiagen, Valencia, USA), 0,15 mM dNTPs, 0,2 μ M primers, and 50 ng of genomic DNA.…”

The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk of uterine leiomyoma (ULM)

“…Then, one article was excluded for not being the Val158Met polymorphism of COMT gene (Jin, 2008). Finally, a total of 12 case-control studies in 7 articles concerning 1506 cases and 1243 controls were included in the meta-analysis (Al-Hendy and Salama, 2006b; Ates et al, 2013;de Oliveira et al, 2008;Denschlag et al, 2006;Gooden et al, 2007;Ivanova et al, 2010;Morikawa et al, 2008). The characteristics and genotype distributions of included studies were listed in Table 1.…”