Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma

Abstract

Genes encoding proteins with antioxidant properties may influence susceptibility to endometrial hyperplasia (EH) and endometrial carcinoma (ECa). Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n = 1110) were genotyped for five polymorphic variants in the genes involved in metabolism of lipoproteins (APOE Cys112Arg and Arg158Cys), iron (HFE Cys282Tyr and His63Asp), and catecholamines (COMT Val158Met). Patients and controls were matched by ethnicity (all Caucasians), age, body mass index (BMI), and incidence of hypertension and diabetes. The frequency of the APOE E 2 allele (158Cys) was higher in patients with EH + ECa than in controls (P = 0.0012, P Bonferroni = 0.018, OR = 2.58, 95% CI 1.49–4.45). The APOE E 4 allele (112Arg) was more frequently found in patients with EH than in controls and HFE minor allele G (63Asp) had a protective effect in the ECa group, though these results appeared to be nonsignificant after correction for multiple comparisons. The results of the study indicate that E 2 allele might be associated with concurrent occurrence of EH and ECa.

Therapeutic options for management of endometrial hyperplasia

“…Significant increase of A1/A1 and a decrease of A1/A2 genotype frequencies have been determined in patients with atypical EH [ 67 ]. A recent study showed a role of functional single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase, apolipoprotein E, and hemochromatosis genes in EH and EC [ 68 ].…”

Prognostic Value of Serum Transferrin Analysis in Patients with Ovarian Cancer and Cancer-Related Functional Iron Deficiency: A Retrospective Case–Control Study

“…The Single Nucleotide Polymorphisms (SNPs) G845A rs 1800562 and C187G rs 1799945 of the HFE gene were genotyped in individuals with elevated TSAT (>40%) or ferritin levels of 400 µg/L or more, as we described earlier [44] (Supplemental S1).…”

Progress in the Study of the Correlation between Apolipoproteins and Endometrial Cancer

“…While most previous studies on Apo E have focused on neurological or ophthalmic diseases, studies on the relationship between Apo E and malignancy have received increasing attention. The results of a study on the association of Apo E2 alleles with the coexistence of endometrial hyperplasia (EH) and EC showed that the frequency of Apo E E2 alleles was significantly higher in the EH + EC group than in the control group (P = 0.0012, PBonferroni = 0.018, OR = 2.58, 95% CI 1.49 to 4.45) [33]. A comparative analysis of gene expression profiles of patients with EC with different degrees of differentiation by Huvila et al…”