Polymorphism of genes associated with increased cardiovascular risk and cognitive function in patients with chronic heart failure and in healthy persons: the pilot study

Martynovich, T.V.; Акимова, Н. С.; Федотов, Э А; Schwartz, Yuri G.

doi:10.15275/rusomj.2015.0102

Cited by 2 publications

(2 citation statements)

References 6 publications

(5 reference statements)

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“…Results of the present study indicated that TT genotypes performed more poorly on measures of attention/processing speed and language, but not executive function. While the lack of genetic effect on executive function may be a result of low power, it is plausible that vascular risk associated with the 268T allele disrupts basic-level cognitive processes (e.g., attention/processing speed, language) prior to disturbances in executive networks [79]. This remains conjecture at this point and longitudinal studies are needed to assess the chronology of vascular-related cognitive changes in aging populations.…”

Section: 0 Discussionmentioning

confidence: 99%

Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition

Salminen

Schofield

Pierce

et al. 2016

Behavioural Brain Research

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The common angiotensinogen (AGT) M268T polymorphism (rs699; historically referred to as M235T) has been identified as a significant risk factor for cerebrovascular pathologies, yet it is unclear if healthy older adults carrying the threonine amino acid variant have a greater risk for white matter damage in specific fiber tracts. Further, the impact of the threonine variant on cognitive function remains unknown. The present study utilized multiple indices of diffusion tensor imaging (DTI) and neuropsychological assessment to examine the integrity of specific white matter tracts and cognition between individuals with homozygous genotypes of M268T (MetMet n = 27, ThrThr n = 27). Differences in subcortical hyperintensity (SH) volume were also examined between groups. Results indicated that the threonine variant was associated with significantly reduced integrity in the superior longitudinal fasciculus (SLF) and the cingulate gyrus segment of the cingulum bundle (cingulum CG) compared to those with the methionine variant, and poorer cognitive performance on tests of attention/processing speed and language. Despite these associations, integrity of these tracts did not significantly mediate relationships between cognition and genetic status, and SH did not differ significantly between groups. Collectively our results suggest that the threonine variant ofM268T is a significant risk factor for abnormalities in specific white matter tracts and cognitive domains in healthy older adults, independent of SH burden.

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Section: 0 Discussionmentioning

confidence: 99%

Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition

Salminen

Schofield

Pierce

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…Standard models of organizing care for patients with CHF are also being developed [6], methods of evaluating its quality and efficacy are being perfected [7] and CHF registries are created [8][9][10][11][12][13][14]. Researchers turn their attention to different aspects of CHF: from influence of low-intensity electromagnetic fields on endothelium function [15] and genetic determinants of CHF [16] to vegetative [17] and cognitive dysfunction [18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of impact of medical therapy and surgical treatment on overall mortality in patients with severe chronic heart failure: a meta-analysis

Olanna¹

2016

Russ Open Med J

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Aim-Meta-analysis of clinical trials comparing the efficacy of medical therapy (MT) and surgical treatment, including cardiac resynchronization therapy with and without cardioversion-defibrillation (CRT and CRT-D), circulatory support system (CSS) and heart transplantation (HT), in terms of decreasing overall mortality in patients with severe chronic heart failure (CHF). Material and Methods-Meta-analysis included 39 clinical trials with a total number of 30,257 patients. Search was performed in MEDLINE, Medscape, Pubmed databases and on web resources, dedicated to clinical trials (National Institutes of Health, Clinical Center, ClinicalStudyResults.org, ClinicalTrials.gov). Results-There was no significant overall mortality reduction in patients receiving MT when compared to control group: OR=0.97 (95% CI: 0.85-1.10), p=0.211. Treatment with CRT and CRT-D, as well as CSS implantation and HT reduced overall mortality: OR=0.67 (95% CI: 0.57-0.79), p < 0.001 for CRT/CRT-D and OR=0.46 (95% CI: 0.24-0.86), p = 0.018 for CSS/HT. Conclusion-Superiority of surgical treatment over traditional MT in terms of overall mortality was observed in patients with severe CHF.

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Polymorphism of genes associated with increased cardiovascular risk and cognitive function in patients with chronic heart failure and in healthy persons: the pilot study

Cited by 2 publications

References 6 publications

Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition

Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition

Comparison of impact of medical therapy and surgical treatment on overall mortality in patients with severe chronic heart failure: a meta-analysis

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