Polymorphism of delta-aminolevulinic acid dehydratase in lead-exposed workers

Ziemsen, B.; Angerer, Jennifer I.; Lehnert, G.; Benkmann, Heide‐G.; Goedde, H. W.

doi:10.1007/bf00432107

Cited by 90 publications

(74 citation statements)

References 2 publications

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“…This was in agreement with the results of Ziemsen et al (28), Steenland and Boffetta (6), Fleming et al (29) and Wetmur et al (30). All these studies examined populations with exposure levels that were higher compared to the normal level, with blood lead levels often >30 µg/dl, which was previously designated as a cut-off used as evidence of lead poisoning.…”

Section: Primary Brain Tumorsupporting

confidence: 92%

Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients

Taha

Gaber

Sabbah

et al. 2015

Molecular and Clinical Oncology

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Abstract. As the δ-aminolevulinic acid dehydratase (ALAD) G177C polymorphism affects the toxicokinetics of lead in the body, and the corresponding exposure to lead may increase the risk of adult brain tumors, we hypothesize that there is a possible association of the ALAD G177C genotype and the risk of brain tumors in human. Therefore, the aim of the present study was to clarify the role of the ALAD enzyme gene polymorphism at position G177C in the pathogenesis of brain tumors and its correlation to lead exposure. The ALAD gene polymorphism at position G177C was genotyped using the polymerase chain reaction with restriction fragment length polymorphism method and measured the blood lead level by atomic absorption in 81 brain tumor patients and compared the results with 81 controls. The frequency of the GC genotype (ALAD1-2) was significantly increased in primary brain tumor patients compared to the control group. The genotype frequency of ALAD2 (ALAD1-2 and ALAD2-2) was significantly higher in the meningioma patients but was not significant in glioma patients. There was no significant difference in the number of patients and blood lead level when compared with the control. There was a significant increase when compared to ALAD1 regarding a mean value of the lead level. The genotyping of the ALAD G177C polymorphism in the present study revealed a significant association between ALAD2 and brain tumors. The ALAD G177C polymorphism may modify the lead kinetics in the blood, is associated with higher blood lead burden and may provide a biomarker of neurotoxic risk.

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Section: Primary Brain Tumorsupporting

confidence: 92%

Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients

Taha

Gaber

Sabbah

et al. 2015

Molecular and Clinical Oncology

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“…Of eight ALAD gene variants, we focused on one polymorphism that yields two alleles, designated ALAD-1 and ALAD-2, which exhibit a codominant pattern of inheritance (40). Ziemsen et al (41) found that lead-exposed workers with the ALAD 1-2 genotype had higher blood lead levels than ALAD 1-1 homozygotes (440 µg L -1 vs. 380 µg L -1 ) and that ALAD 2-2 homozygotes had still higher blood lead levels (560 µg L -1 ). Hypotheses based on the charge of the ALAD-2 isozyme (42) imply that the ALAD 1-2 and 2-2 genotypes are the "at-risk genotypes" at high exposure levels.…”

Section: Discussionmentioning

confidence: 99%

Adverse Effects in Workers Exposed to Inorganic Lead

Stoleski¹,

Karadžinska-Bislimovska²,

Стикова³

et al. 2008

Archives of Industrial Hygiene and Toxicology

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This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were assessed using data obtained from a specially designed Questionnaire for lead exposure and toxic effects assessment, physical examination, spirometry, ECG, and laboratory tests including blood lead level (BLL) and biomarkers of lead toxic effects. Muscle pain, droopiness, and work-related nasal symptoms were significantly more frequent in lead workers. The prevalence of lung symptoms was higher in lead workers than in controls, but not significantly (20 % vs. 6.6 %, respectively). Mean values of BLL and δ-aminolevulinic acid (ALA) were significantly higher in lead workers. The activity of δ-aminolevulinic acid dehydratase (ALAD) in lead workers was significantly lower than in controls. Abnormal of BLL, ALAD, and ALA were more frequent in lead workers, with statistical difference for BLL and ALAD. Inverse correlation was found between BLL and ALAD, and positive correlation between BLL and age, years of employment, and years of exposure. Inverse correlation was found between ALAD and age, years of employment, years of exposure, blood pressure, alcohol consumption, and years of alcohol consumption. Changes in spirometry correlated inversely with BLL. A positive correlation was found between BLL and erythrocyte count and haemoglobin concentration, whereas it was inverse for ALAD and haemoglobin concentration. A significant difference was found for BLL and ALAD, with a very high odds ratio (14.64 and 7.23, respectively) and high relative risk (4.18 and 3.08, respectively). Our data have confirmed the association between occupational lead exposure and deviation in specific biological markers of lead effect and between the role of occupational exposure in the development of adverse effects.

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“…Creatinine in urine was analyzed by the Sigma kit (St. Louis, Missouri, United States) (33). ALAD and VDR genotyping were completed for 798 exposed subjects and 795 referents by previously described methods (34)(35)(36)(37).…”

Section: Laboratory Methodsmentioning

confidence: 99%

Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers

Lee

et al. 2001

Scand J Work Environ Health

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Polymorphism of delta-aminolevulinic acid dehydratase in lead-exposed workers

Cited by 90 publications

References 2 publications

Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients

Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients

Adverse Effects in Workers Exposed to Inorganic Lead

Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers

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