Polymorphism of Alcohol Dehydrogenase Genes in Alcoholic and Nonalcoholic Individuals from Valencia (Spain)

Espinós, Carmen; Sánchez, Francisco; Ramírez, Carlos; Juan, Florence Giannina F. San; Nájera, Carmén

doi:10.1111/j.1601-5223.1997.00247.x

Cited by 17 publications

(12 citation statements)

References 30 publications

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“…The studies report conflicting findings with no correlation [11,36,37,38], protection against alcohol dependence [8,10] or inconclusive results [39,40]. In contrast to our study, Borras et al [8] and Espinos et al [11] found that the ADH1C * 1 allele was more frequent in alcohol-dependent patients compared to that of non-drinkers in Europeans. Similarly, Cichoz-Lach et al [10] showed that the ADH1C * 1 allele and ADH1C * 1/ * 1 genotype were detected significantly more frequently in the alcohol-dependent group than in the control group.…”

Section: Discussioncontrasting

confidence: 50%

“…Among these, a functional relevance of the ADH1C genetic polymorphisms that appear to impact on ethanol metabolism and susceptibility to alcoholism has been reported [7]. Its role in the development of alcohol dependence differs according to ethnicity [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28]. Furthermore, small studies have generated somewhat inconsistent results, especially in populations where the minor allele frequency is low, which would serve to reduce statistical power.…”

Section: Introductionmentioning

confidence: 99%

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Association of a Genetic Polymorphism of the Alcohol-Metabolizing Enzyme ADH1C with Alcohol Dependence: Results of a Case-Control Study

Kortunay

Köseler²,

Özdemir³

et al. 2012

Eur Addict Res

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Objective: Alcohol dependence causes serious problems which may be influenced by genetic factors associated with alcohol metabolism. The aim was to investigate the allelic and genotypic difference in distribution of a polymorphism in alcohol dehydrogenase 1C gene (ADH1C) between alcohol-dependent individuals and controls, and to examine if these genotypes were associated with the age at which the patient became alcohol-dependent. Methods: We conducted a case-control study including 90 alcohol-dependent cases and 100 historic controls. The genomic DNA was isolated and the alleles were analyzed with an RFLP. Results: The ADH1C*1 allele frequencies were 0.89 (95% CI 0.84–0.91) in controls and 0.68 (95% CI 0.61–0.74) in alcohol-dependent patients. The frequencies of the ADH1C*2 allele were 0.11 (95% CI 0.07–0.14) and 0.32 (95% CI 0.25–0.38) among controls and alcohol-dependent patients, respectively (p < 0.0001). The ADH1C*1/*1 genotype frequency was significantly higher in the control group (77%) compared to that of the alcohol-dependents (51%, p < 0.0001). The ADH1C*1/*2 genotype frequency was significantly lower in the control group (23%) compared to that of the alcohol-dependents (42%, p < 0.0001). We obtained no statistically significant difference among the ADH1C genotype groups regarding age. Conclusions: These findings suggest that a significantly higher presence of ADH1C*2 allele is associated with alcohol dependence in a Turkish population. Studies with other related polymorphisms are needed to more precisely estimate the association of alcohol dependence with ADH1C.

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Section: Discussioncontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Association of a Genetic Polymorphism of the Alcohol-Metabolizing Enzyme ADH1C with Alcohol Dependence: Results of a Case-Control Study

Kortunay

Köseler²,

Özdemir³

et al. 2012

Eur Addict Res

View full text Add to dashboard Cite

show abstract

“…Borras at al. (3) and Espinos et al (22), who studied Europeans, found that the ADH1C*1 allele was more frequent in alcohol-dependent subjects than among non-drinkers. Similarly, the results of the present study show that the ADH1C*1 allele and ADH1C*1/*1 genotype were detected significantly more frequently in the alcohol-dependent group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Studies regarding ADH1C*1 among whites are more contradictory and show ambiguous findings: no correlation (13,22,23), protection against alcohol dependence (3) or inconclusive results (24,25). Borras at al.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men

Cichoż‐Lach

Celiński

Wojcierowski

et al. 2010

Braz J Med Biol Res

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“…Eight studies in alcoholism 28,33,38,39,44,56,65,66 and two studies in liver disease 33,44 reported that the controls were age-or sex-matched. Studies were conducted in various populations of racial background: 24 involved Caucasians, 5 …”

Section: Eligible Studiesmentioning

confidence: 99%

Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?

et al. 2006

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Case-control studies that have investigated the association between alcoholism and alcoholinduced liver damage and the ADH2, ADH3, CYP2E1, and ADLH2 polymorphisms have reported controversial or inconclusive results. Thus, we conducted a meta-analysis of 50 association studies of the above polymorphisms. We explored potential sources of heterogeneity and bias, performed subgroup analyses by racial background and sex, performed sensitivity analyses for studies not in Hardy-Weinberg equilibrium, and performed a subgroup analysis for cases that met strict criteria for alcoholism. The present meta-analysis underscores significant associations of ADH2*1, ADH3*2, and ALDH2* . When strict criteria were imposed, the pattern of results remained unaltered. For liver disease, there were no significant associations for ADH2*1, ADH3*2, or ALDH2*1 in all subpopulations. The CYP2E1 polymorphism showed no association whatsoever. There is evidence that alleles are mainly dominant. In conclusion, there was heterogeneity between studies in alcoholism for ADH2, ADH3, and ALDH2, and lack of bias in all polymorphisms. The above findings reinforce the need for more rigorous studies, and for regular synthesis of studies' results. O ver the last few years, an increasing number of studies have provided compelling evidence for the involvement of genetically defined predisposing factors in alcoholism and alcohol-induced cirrhosis. The strongest support comes from the fact that not all subjects with a high daily intake of alcohol develop alcohol-induced liver disease. Mostly metabolized in the liver by the successive action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the rate of conversion of ingested ethanol to acetaldehyde, and of acetaldehyde to acetate, is influenced by genetic polymorphisms at both loci. ALDH2 is the most important gene that affects predisposition to alcoholism in Asian populations. Thus, the prevalence in these populations of the inactive ALDH enzymatic form encoded by the ALDH2*2 allele appears to protect against alcoholism. 1 Furthermore, alcoholics with this inactive allele may be at great risk for advanced alcoholic liver disease. [2][3][4] Regarding the ADH gene cluster, polymorphisms are also detected at the ADH2 and ADH3 loci with two alleles (referred to as *1 and *2) each. Alleles ADH2*2 and ADH3*1 encode, respectively, for the highly active ␤ 2 and ␥ 1 allozymes, 5 and a low prevalence of both alleles has been reported in alcoholic Asians-although some studies did not detect associations between ADH3 polymor-

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Polymorphism of Alcohol Dehydrogenase Genes in Alcoholic and Nonalcoholic Individuals from Valencia (Spain)

Cited by 17 publications

References 30 publications

Association of a Genetic Polymorphism of the Alcohol-Metabolizing Enzyme ADH1C with Alcohol Dependence: Results of a Case-Control Study

Association of a Genetic Polymorphism of the Alcohol-Metabolizing Enzyme ADH1C with Alcohol Dependence: Results of a Case-Control Study

Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men

Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?

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