Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men

Cichoż‐Lach, Halina; Celiński, Krzysztof; Wojcierowski, Jacek; Słomka, Maria; Lis, Ernest

doi:10.1590/s0100-879x2010007500006

Cited by 18 publications

(14 citation statements)

References 39 publications

(44 reference statements)

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“…However, the results regarding the effect of these mutations are not so obvious among Caucasians. Although previous meta-analyses and other studies [8,9,13,14] did not find an association between these alleles and alcoholism or liver disease, some researchers have described associations with alcohol drinking habits and/or alcoholism among Europeans [18,30,32]. However, while our results confirm the lack of association with CLDs, we did find a significantly increased OR for problem drinking (i.e.…”

Section: Discussioncontrasting

confidence: 85%

“…In previous years, the potential role of the quality of alcohol consumed in this region has been examined [25,26] but potential genetic factors have received less attention. Although research has been conducted in other European countries [12][13][14]16,18,[27][28][29][30][31][32], the combined effects of the main polymorphisms remain to be clarified. In a previous study [22], we have taken a first step by mapping the prevalence of ADH1B Arg48His in Hungary.…”

Section: Discussionmentioning

confidence: 99%

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Combined Effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 Alleles on Alcoholism and Chronic Liver Diseases

et al. 2011

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Abstract. The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary. The study included men, aged 45-64 years. Altogether, 241 cases with chronic liver disease (CLD) and 666 randomly selected controls without CLD were analysed for all four polymorphisms. Associations between the polymorphisms, individually, and in combination, and excessive and problem drinking and CLD, were assessed using logistic regression. In this study we have identified a novel mutation, called ADH1B Arg370His. The ADH1C Arg272Gln and Ile350Val showed almost complete linkage. The 272Gln/350Val allele increased the risk of excessive and problem drinking in homozygous form (OR = 1.582, p = 0.035, CI = 1.034-2.421, OR = 1.780, p = 0.016, CI = 1.113-2.848, respectively). The joint analysis showed that when combined with the wild type ADH1C Arg272/Ile350 allele, the ADH1B 48His is protective against CLD (OR = 0.368, p = 0.019, CI = 0.159-0.851). The results obtained in the study help not only to clarify the effects of different ADH SNPs but to better understand how these polymorphisms modify each other's effects in the development of alcoholism and related diseases.

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Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Combined Effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 Alleles on Alcoholism and Chronic Liver Diseases

et al. 2011

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“…Making meaningful comparison of our results to other studies in the region is therefore difficult. The frequency of the His47 carriers in the neighboring Polish, German, and Hungarian populations have been reported to be 11, 10 and 18%, respectively (Cichoz‐Lach et al., 2010; Lilla et al., 2005; Toth et al., 2010), which is similar to our results and significantly higher than in western European populations. Unfortunately, these studies were not primarily focused on the associations between ADH1B and with alcohol intake.…”

Section: Discussionsupporting

confidence: 92%

ADH1B Polymorphism, Alcohol Consumption, and Binge Drinking in Slavic Caucasians: Results from the Czech HAPIEE Study

Hubacek

Pikhart

Peasey

et al. 2011

Alcoholism Clin & Exp Res

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Background Several genetic polymorphisms influence the risk of heavy alcohol consumption but it is not well understood whether the genetic effects are similar in different populations and drinking cultures, nor whether the genetic influences on binge drinking are similar to those seen for alcoholism. Methods We have analysed the effect of the Arg47His (rs1229984) variant within the alcohol dehydrogenase (ADH1B) gene on a range of drinking related variables in a large Eastern European Slavic population (Czech HAPIEE study), which recruited random samples of men and women aged 45–69 years in six Czech towns (3,016 males and 3,481 females with complete data). Drinking frequency, annual alcohol intake, prevalence of binge drinking (≥100g in men and ≥60g in women at least once a month) and the mean dose of alcohol per occasion were measured by the graduated frequency questionnaire. Alcohol intake in a typical week was used to define heavy drinking (≥350g/week in men and ≥210g in women). Problem drinking (≥2 positive answers on CAGE) and negative consequences of drinking on different aspects of life were also measured. Results The frequency of the His47 allele carriers was 11%. Homozygotes in the common allele (Arg47Arg), among both males and females, had significantly higher drinking frequency, and annual and weekly intake of alcohol than His47 carriers. The odds ratio of heavy drinking in Arg47Arg homozygotes vs. His47 carriers was 2.1 (95% confidence intervals 1.1–3.2) in men and 2.2 (1.0–4.7) in women. In females, but not in males, Arg47Arg homozygotes had marginally significantly higher prevalence of binge drinking and mean alcohol dose per drinking session. There was no consistent association with problem drinking and negative consequences of drinking. Conclusions The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.

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“…The present study suggests a possible effect of Arg48His SNP in ADH1B gene with HD and BD in HIV‐1‐infected people from southern Brazil. Previous studies with non‐HIV‐1‐infected individuals detected a strong association between this SNP and HD in general population of different ethnicities: Euro‐Americans, Mexican Americans, Europeans, and Asians (Bierut et al., ; Cichoz‐Lach et al., ; Ehlers et al., ; Gelernter et al., ; Hart et al., ; Hubacek et al., ; Li et al., ; Luo et al., ; Meyers et al., ; Toth et al., ; Way et al., ). This SNP was associated with BD in Euro‐Americans (Hart et al., ; Xu et al., ) and mental illness and alcohol misuse in a Japanese sample (Yoshimasu et al., ).…”

Section: Discussionmentioning

confidence: 94%

Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV‐1‐Positive Individuals

Wolf

Simon

Béria

et al. 2017

Alcoholism Clin & Exp Res

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Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men

Cited by 18 publications

References 39 publications

Combined Effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 Alleles on Alcoholism and Chronic Liver Diseases

Combined Effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 Alleles on Alcoholism and Chronic Liver Diseases

ADH1B Polymorphism, Alcohol Consumption, and Binge Drinking in Slavic Caucasians: Results from the Czech HAPIEE Study

Analysis of the Association of Nonsynonymous Polymorphisms in ADH Genes with Hazardous Drinking in HIV‐1‐Positive Individuals

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