Polymorphism in the tumor necrosis factor-? promotor region and in the heat shock protein 70 genes associated with malignant tumors

Chouchane, Lotfi; Ahmed, Slim Ben; Baccouche, Sami; Remadi, Sami

doi:10.1002/(sici)1097-0142(19971015)80:8<1489::aid-cncr17>3.0.co;2-1

Cited by 103 publications

(91 citation statements)

References 30 publications

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“…The less common allele, G-308A, was actually too rare in the present data sets to provide adequate statistical power for investigation. The frequency of the -308A allele was 1.3% (n ϭ 240) in this study and 1.7% (n ϭ 575) in another Japanese study [13], 3.1% (n ϭ 113) in Koreans [9], 7.4% (n ϭ 121) in Chinese [27], and 16.5% in Tunisia [26]. The TNF-A -857T allele is not rare, and its frequency seems to be similar among ethnic groups; 17.0% (457/2690) in this study, 17.3% (n ϭ 575) in another study in Japan [13], and 23.2% (n ϭ 235) in Northern Ireland [28].…”

Section: Discussionsupporting

confidence: 44%

“…The finding that IL-1B C-31T was associated with H. pylori seropositivity [4][5][6][7] prompted us to examine TNF-A and TNF-B polymorphisms. The documented associations between TNF polymorphisms and several diseases [13,[26][27][28][29] indicate that these polymorphisms are functional or that they are linked with a functional polymorphism, and this feature was also part of the rationale for the present study.…”

Section: Discussionmentioning

confidence: 81%

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Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

Hamajima

Shibata

Katsuda³

et al. 2003

Gastric Cancer

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Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 81%

Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

Hamajima

Shibata

Katsuda³

et al. 2003

Gastric Cancer

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“…Associations in several cancers including breast, liver, and gastric cancers have also been reported (Chouchane et al 1997;Mestiri et al 2001;Jeng et al 2008;Shibata et al 2009). The most commonly examined polymorphism is the PstI polymorphism in nucleotide 1267 of HSPA1B (rs1061581).…”

Section: Introductionmentioning

confidence: 81%

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Ucisik-Akkaya

Davis

Gorodezky

et al. 2010

Cell Stress and Chaperones

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Three heat shock protein 70 (HSP70) genes, HSPA1L, HSPA1A, and HSPA1B, are located within the human leukocyte antigen (HLA) class III region. HSPs act as stress signals and regulate natural killer cell response to cancer. HSP70 gene polymorphisms show disease associations partly due to their linkage disequilibrium with HLA alleles. To systematically evaluate their associations with childhood acute lymphoblastic leukemia (ALL), we examined the three functional single nucleotide polymorphisms (SNPs) rs2227956 (T493M) in HSPA1L, rs1043618 in HSPA1A 5′UTR, and rs1061581 (Q351Q) in HSPA1B by TaqMan assays or polymerase chain reaction-restriction fragment length polymorphism in 114 ALL cases and 414 controls from Wales (UK), in 100 Mexican Mestizo ALL cases and 253 controls belonging to the same ethnic group, and in a panel of 82 HLA-typed reference cell line samples. Homozygosity for HSPA1B rs1061581 minor allele G was associated with protection (odds ratio (OR)=0.37, 95% confidence interval (CI)=0.16-0.78; P=0.007) with genedosage effect (additive model) reaching significance (P= 0.0001) in the Welsh case-control group. This association was replicated in the second case-control group from Mexico (OR (recessive model)=0.49, 95% CI=0.24-0.96; P=0.03), and the pooled analysis yielded a strong association (Mantel-Haenszel OR=0.43, 95% CI=0.27-0.69, P= 0.0004). The association was stronger in males in each group and in the pooled analysis. A three-SNP haplotype including the major allele A of rs1061581 showed a highly significant increase in Welsh cases compared with respective controls (6.7% vs 1.8%; P=0.0003) due to the difference between male cases and controls. The protective allele of rs1061581 occurred more frequently on the HLA-DRB3 haplotypes (especially DRB1*03) in the cell line panel, but the HSPA1B association was independent from the HLA-DRB4 association previously detected in the same case-control group from Wales (adjusted P=0.001). Given the cancer promoting roles played by HSPs intracellularly as well as roles in immune surveillance when expressed on the cell surface and the known correlations between expression levels and the HSP polymorphisms, these results are likely to indicate a primary association and warrant detailed assessment in childhood ALL development.

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“…Although we did not measure circulating TNF-α levels, TNF-α-308*A allele has already been shown to increase the constitutive and inducible expression of TNF-α protein, possibly caused by the differential binding of a nuclear protein to the TNF-α-308*A allele (Kroeger et al, 1997;Wilson et al, 1997). It has been reported that some malignant tumors such as prostate cancer, nonHodgkin's lymphoma and breast carcinoma are related to TNF-α-308*A/G gene polymorphism (Chouchane et al, 1997;Oh et al, 2000;Jeng et al, 2007). Our result shows that TNF-α-308*A/G gene polymorphism is not related to hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Association Between EGF, TGF-β1 and TNF-α Gene Polymorphisms and Hepatocellular Carcinoma

Shi

Ren²,

Lu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Polymorphism in the tumor necrosis factor-? promotor region and in the heat shock protein 70 genes associated with malignant tumors

Cited by 103 publications

References 30 publications

Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Association Between EGF, TGF-β1 and TNF-α Gene Polymorphisms and Hepatocellular Carcinoma

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