Association Between EGF, TGF-β1 and TNF-α Gene Polymorphisms and Hepatocellular Carcinoma

Shi, H.; Ren, Peng; Lu, Qingjun; Niedrgethmnn, Marco; Wu, Guoyang

doi:10.7314/apjcp.2012.13.12.6217

Cited by 23 publications

(22 citation statements)

References 28 publications

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“…Similarly, recent case-control study as well as metaanalysis have shown no association of TGF β1 -509T*C with the risk of hepatocellular carcinoma or overall cancer risk (Liu et al, 2012;Shi et al, 2012). However, some studies have reported that TGF-β1 *29C was protective against breast cancer and suggested that *29C is a protective allele and *29T a risk allele by showing that the individuals with C/C genotype had a significantly lower risk of developing breast cancer compared to those with the T/T or T/C genotype (Ziv et al, 2001;Hishida et al, 2003;Joshi et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

Alqumber¹,

Dar²,

Haque³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The transforming growth factor-β1 (TGF-β1) gene 29 T/C polymorphism is thought to be associated with breast cancer risk. However, reports are largely conflicting and underpowered. We therefore conducted a metaanalysis of all available case-control studies relating the TGF-β1 29T/C polymorphism to the risk of developing breast cancer by including a total of 31 articles involving 24,021 cases and 31,820 controls. Pooled ORs were generated for the allele contrasts, with additive genetic, dominant genetic and recessive genetic models. Subgroup

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Section: Discussionmentioning

confidence: 99%

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

Alqumber¹,

Dar²,

Haque³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Fourteen association studies relating to the TGF-b1 polymorphisms with susceptibility to HCC met the inclusion requirements for the meta-analysis (Ben-Ari et al, 2003;Kwon et al, 2003;Migita et al, 2005;Falleti et al, 2008;Zhang, 2008;Qin, 2009Qin, , 2012Okamoto et al, 2010;Miki et al, 2011;Yang, 2011;Radwan et al, 2012;Shi et al, 2012;Xin et al, 2012;Wei et al, 2012). There were six studies on + 869C/T polymorphism, nine studies on -509C/T polymorphism, and three studies on + 915C/G polymorphism.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five polymorphisms have been identified: two in the promoter region at positions -800 and -509, one at position + 72 in a nontranslated region, and two in the signal sequence at positions + 869 and + 915. Some studies have investigated the associations between the TGF-b1 polymorphisms and susceptibility of HCC (Ben-Ari et al, 2003;Kwon et al, 2003;Migita et al, 2005;Falleti et al, 2008;Zhang, 2008;Qin, 2009Qin, , 2012Okamoto et al, 2010;Miki et al, 2011;Yang, 2011;Radwan et al, 2012;Shi et al, 2012;Xin et al, 2012;Wei et al, 2012). Most of the studies focused on two polymorphisms: + 869C/T (rs1800470) and -509C/T (rs1800469).…”

Section: Introductionmentioning

confidence: 99%

Association Between TGF-β1 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

Guo

Zang²,

Li³

et al. 2013

Genetic Testing and Molecular Biomarkers

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Background: Associations between transforming growth factor (TGF)-b1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations. Methods: We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results: A total of 14 studies were included in this meta-analysis. TGF-b1 + 869C/T polymorphism was significantly associated with HCC risk (OR = 1.74, 95% CI: 1.22-2.47, p = 0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR = 1.40, 95% CI: 1.15-1.70, p = 0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies. Conclusions: Our meta-analysis suggested that the TGF-b1 + 869C/T and -509C/T polymorphisms may be risk factors for developing HCC.

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“…Some studies have also described TGF-β1 gene variants in codons 10 and 25 of exon 1 and at the promoter region positions -800 and -509 [11,12]. Among these variants, TGF-β1 -509 C>T variants (rs1800469) have been most frequently examined as a possible genetic factor contributing to HCC susceptibility [13][14][15][16][17][18][19][20][21]. However, these studies have yielded conflicting results.…”

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confidence: 99%

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

Toshikuni¹,

Matsue²,

Minato³

et al. 2016

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The transcriptional activity of transforming growth factor-β (TGF-β) is increased in subjects with hepatocellular carcinoma (HCC). Recent studies have indicated that the -509C genotype in hepatitis B virus (HBV)-infected subjects and the -509T genotype in hepatitis C virus (HCV)-infected subjects can increase the transcriptional activity of the TGF-β1 gene. We conducted a meta-analysis to clarify whether these two hepatitis viruses affect the association between TGF-β1 C-509T variants and HCC susceptibility. Using data derived from 8 case-control studies available in the PubMed database (5 with Asian and 3 with Caucasian populations), including 1,427 cases and 3,735 controls [1,610 patients with chronic liver disease and 2,125 healthy controls], we calculated pooled odds ratios with corresponding 95% confidence intervals. We used dominant (TT + CT vs. CC), recessive (TT vs. CC + CT), and co-dominant (TT vs. CC and CT vs. CC) genetic models. An overall analysis showed no association between the TGF-β1 C-509T variants and HCC susceptibility for all models. In contrast, a subgroup analysis, based on the infecting hepatitis viruses, provided the following results. Among the cases and controls with chronic liver disease, the TGF-β1 C-509T variants were significantly associated with decreased HCC susceptibility for two models with HBV-infected subjects, whereas the variants were significantly associated with increased HCC susceptibility for one model with HCV-infected subjects. Among the cases and healthy controls, there was a significant association between the TGF-β1 C-509T variants and increased HCC susceptibility for two models involving HCV-infected subjects. Among the cases and the entire control group, the same results were obtained for all genetic models with HCV-infected subjects. Although further data accumulation is required, our results suggest that these two hepatitis viruses affect the association between TGF-β1 C-509T variants and HCC susceptibility in opposite manners.

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Association Between EGF, TGF-β1 and TNF-α Gene Polymorphisms and Hepatocellular Carcinoma

Cited by 23 publications

References 28 publications

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

Association Between TGF-β1 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

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