Polymorphism at the Glutathione S-Transferase P1 Locus in Korean Patients with Perennial Allergic Rhinitis

Chung, Yoo‐Sam; Cha, Heung-Eog; Kang, Il-Gyu; Hwang, You-Jin; Kim, Seon-Tae

doi:10.2500/ajr.2006.20.2950

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…However, the G allelic frequencies in the control groups of the study by Hur et al 10 . and ours were similar to those found in other Korean studies (16.6–21.5%) 17–21 …”

Section: Discussionsupporting

confidence: 91%

ORIGINAL ARTICLE: No Association Between the GSTP1 Exon 5 Polymorphism and Susceptibility to Advanced Stage Endometriosis in the Korean Population

Jeon

Choi

Min

et al. 2010

American J Rep Immunol

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“…However, the G allelic frequencies in the control groups of the study by Hur et al 10 . and ours were similar to those found in other Korean studies (16.6–21.5%) 17–21 …”

Section: Discussionsupporting

confidence: 91%

ORIGINAL ARTICLE: No Association Between the GSTP1 Exon 5 Polymorphism and Susceptibility to Advanced Stage Endometriosis in the Korean Population

Jeon

Choi

Min

et al. 2010

American J Rep Immunol

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“…Previous epidemiologic studies suggested that tobacco smoke could increase risk of allergic rhinitis. Diaz-Sanchez and colleagues found increased levels of allergen-specific IgE in the nasal lavages of ragweed allergic subjects exposed to environmental tobacco smoke vs. clean air [9], and a small study by Chung and colleagues had suggested the possibility of an association between GSTs and allergic rhinitis [10]. These findings were from small studies, and Gerbase and colleagues found no evidence for these associations in this larger study.…”

mentioning

confidence: 68%

Unravelling gene‐by‐environment effects in asthma and allergy: the glutathione pathway as an early success story

Rogers

Bunyavanich

2011

Clin Experimental Allergy

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Human Glutathione S-Transferase Enzyme Gene Polymorphisms and Their Association With Neurocysticercosis

Prasad

Singh

et al. 2016

Mol Neurobiol

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Neurocysticercosis (NCC), caused by cysticerci of Taenia solium is the most common helminthic infection of the central nervous system. Some individuals harboring different stages of cysticerci in the brain remain asymptomatic, while others with similar cysticerci lesions develop symptoms and the reasons remain largely unknown. Inflammatory response to antigens of dying parasite is said to be responsible for symptomatic disease. Reactive oxygen species (ROS) that are generated in inflammatory conditions can damage cellular macromolecules such as lipids, DNA, and proteins. The glutathione S-transferases (GSTs) are critical for the protection of cells from ROS. A total of 250 individuals were included in the study: symptomatic NCC = 75, asymptomatic NCC = 75, and healthy controls = 100. The individuals carrying the deletions of GSTM1 and GSTT1 were at risk for NCC (OR = 2.99, 95 %CI = 1.31-6.82, p = 0.0073 and OR = 1.94, 95 %CI = 0.98-3.82, p = 0.0550 respectively). Further, the individuals with these deletions were more likely to develop symptomatic disease (OR = 5.08, 95 % CI = 2.12-12.18, p = 0.0001 for GSTM1 and OR = 3.25, 95 %CI = 1.55-6.82, p = 0.0018 for GSTT1). Genetic variants of GSTM3 and GSTP1 were not associated with NCC. The total GST activity and levels of GSTM1, GSTT1, and GSTM3 were significantly higher in asymptomatic subjects than in symptomatic and healthy controls. Lower GST activity was observed in individuals with GSTM1 and GSTT1 deletions. The present study suggests that the individuals with GSTM1 and GSTT1 deletions are at higher risk to develop symptomatic disease. The higher GST activity and levels of GSTM1, GSTT1, and GSTM3 are likely to play role in maintaining asymptomatic condition.

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Polymorphism at the Glutathione S-Transferase P1 Locus in Korean Patients with Perennial Allergic Rhinitis

Abstract: Our results indicate that the Val/Val genetic polymorphism of GSTP1 may exert some protective effects in allergic inflammation.

Cited by 7 publications

References 18 publications

ORIGINAL ARTICLE: No Association Between the GSTP1 Exon 5 Polymorphism and Susceptibility to Advanced Stage Endometriosis in the Korean Population

ORIGINAL ARTICLE: No Association Between the GSTP1 Exon 5 Polymorphism and Susceptibility to Advanced Stage Endometriosis in the Korean Population

Unravelling gene‐by‐environment effects in asthma and allergy: the glutathione pathway as an early success story

Human Glutathione S-Transferase Enzyme Gene Polymorphisms and Their Association With Neurocysticercosis

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