“…527–534) have investigated the inflammatory response to allergen challenge in people with asthma with differing GST P1 genotypes at the Ile105Val locus and found that people who were homozygous for val‐val had a greater release of inflammatory mediators than those who were heterozygous or homozygous for Ile‐Ile, although there was no effect on lung function. Interestingly, we have previously reported that the val‐val genotype was associated with lower total and specific IgE especially in smokers, illustrating the complexity of these genetic associations . …”
Section: Genetics Of Asthma: Glutathione‐s‐transferasementioning
“…527–534) have investigated the inflammatory response to allergen challenge in people with asthma with differing GST P1 genotypes at the Ile105Val locus and found that people who were homozygous for val‐val had a greater release of inflammatory mediators than those who were heterozygous or homozygous for Ile‐Ile, although there was no effect on lung function. Interestingly, we have previously reported that the val‐val genotype was associated with lower total and specific IgE especially in smokers, illustrating the complexity of these genetic associations . …”
Section: Genetics Of Asthma: Glutathione‐s‐transferasementioning
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