Polymorphism at position −174 of IL‐6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population

Trevilatto, Paula Cristina; Scarel‐Caminaga, Raquel Mantuaneli; Brito, Rui Barbosa de; Souza, Ana Paula de; Line, Sérgio Roberto Peres

doi:10.1034/j.1600-051x.2003.20016.x

Cited by 123 publications

(127 citation statements)

References 39 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…However, in this study, IL-6 GG genotypes could not modify the risk of chronic periodontitis but increased the risk of aggressive periodontitis. Several studies have been published on whether the IL-6 polymorphism predisposes to periodontitis (29)(30)(31). However, the results of studies on the associations between these polymorphism and clinical forms of periodontitis are contradictory (13,19,32,33).…”

Section: Genotypes and Alleles Distribution Of Polymorphisms In The Nmentioning

confidence: 93%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

View full text Add to dashboard Cite

SUMMARYObjective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis.Methods: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p = 0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR = 9.93, 95% CI: 2.11-46.7, OR = 5.7, 95% CI: 1.22-26.89, respectively).Conclusions: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/ aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis.Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.

show abstract

Section: Genotypes and Alleles Distribution Of Polymorphisms In The Nmentioning

confidence: 93%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

View full text Add to dashboard Cite

show abstract

“…First, Trevilatto et al reported an association between IL-6(-174) gene polymorphism and CP in the Caucasian race. 11 After that,several studies found different results regarding the relationship between IL-6(-174) gene polymorphism and periodontal disease. Some of these studies did not find any association between IL-6(-174) gene polymorphism and CP, 12,13,14,15 however some others found associations.…”

Section: Introductionmentioning

confidence: 99%

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

et al. 2017

View full text Add to dashboard Cite

“…Moreover, the host response is influenced by several possible risk factors including genetic factors. Previous studies indicated that chronic periodontitis (CP) may have a genetic background (12,13), as well as PID (14,15).…”

Section: Introductionmentioning

confidence: 99%

History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

et al. 2013

View full text Add to dashboard Cite

The success rates in implant dentistry vary significantly among patients presenting previous history of periodontitis. The aim of this study was to evaluate if patients with history of chronic periodontitis (CP) are more susceptible to peri-implant disease (PID) than those without history of CP. Two hundred and fifteen individuals, under periodontal maintenance, presenting 754 osseointegrated implants, were selected for this study. The patients were divided into two groups according to the peri-implant status: Control group (patients without PID; n=129) and PID group (patients with PID; n=86). All peri-implant regions were clinically evaluated, including analyses of mucosa inflammation, edema and implant mobility. Periapical radiography assessed the presence of peri-implant bone loss. According to the clinical/radiographic characteristics, patients in Control and PID groups were diagnosed as having CP or not. Nominal variables were evaluated by the chi-square test. The distribution of numeric variables was analyzed by Shapiro-Wilk test. Student's t-test and Mann-Whitney test were used to analyze significant differences for parametric and non-parametric data. A p-value <0.05 was considered significant. There was a highly significant correlation between CP history and PID (p<0.0001). Patients with CP had 4 times more chance of developing PID than patients with healthy periodontal tissues. Also, CP patients showed higher bleeding on probing (p=0.002) and bone loss around implant (p=0.004) when compared with patients without CP. In conclusion, history of CP is a high risk factor for the development of PID, irrespective of gender or region of implant placement.

show abstract

Polymorphism at position −174 of IL‐6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population

Abstract: We concluded that the IL-6-174 polymorphism is associated with susceptibility to chronic periodontitis in the population studied.

Cited by 123 publications

References 39 publications

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

Contact Info

Product

Resources

About