Polymorphism and Synergism of the Hemostasis System Genes in Pathogenesis of Infective Endocarditis

Мальцева, Н. В.; Лапутенко, Т А; Smirnova, AG; Kan, Shigenao

doi:10.29296/24999490-2019-04-07

Search citation statements

Order By: Relevance

Paper Sections

Select...

патофизиологические механизмы локального нарушения гемостаза...1

Citation Types

Supporting

Mentioning

Contrasting

Unclassified

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Крайне важны условия, способствующие образованию вегетации и вклад в этот процесс звеньев системы гемостаза (рис. 1) [8][9][10][11][12][13][14][15][16][17].…”

Section: патофизиологические механизмы локального нарушения гемостаза...unclassified

Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)

Pisaryuk

Zamarashkina

Safarova

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agents (mostly bacteria) to be cloaked from the immune system and to multiply freely, leading to growth of vegetation, thus resulting in higher chance of fragmentation. Small-scale experimental and clinical studies on the correction of hemostatic disorders in infective endocarditis, that were performed in 20th century, didn’t show any significant results, that could affect clinical practice. However, reinterpretation of available data on coagulative system will allow to have elements of hemostasis as an application point in treating infective endocarditis. The article will discuss latest insights on the role of hemostasis system in pathophysisology of infective endocarditis, its effects on the development of the embolic complications, perspectives for diagnostics and treatment.

show abstract

Section: патофизиологические механизмы локального нарушения гемостаза...unclassified

Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)

Pisaryuk

Zamarashkina

Safarova

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

show abstract

Polymorphism and Synergism of the Hemostasis System Genes in Pathogenesis of Infective Endocarditis

Cited by 1 publication

References 0 publications

Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)

Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)

Contact Info

Product

Resources

About