Polymorphism and Solvatomorphism 2007

Brittain, Harry G.

doi:10.1002/jps.21518

Cited by 49 publications

(41 citation statements)

References 209 publications

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“…[5][6][7][8][9] The present review continues the annual reviews of this field, will summarize works that have been published during 2010, with the papers and patents cited in the present review being drawn primarily from the major physical, crystallographic, and pharmaceutical journals. As always, the coverage cannot be represented as being totally comprehensive, and consequently apologies are offered in advance to any scientist whose works have been inadvertently omitted.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism and Solvatomorphism 2010

Brittain¹

2012

Journal of Pharmaceutical Sciences

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128

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Section: Introductionmentioning

confidence: 99%

Polymorphism and Solvatomorphism 2010

Brittain¹

2012

Journal of Pharmaceutical Sciences

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128

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“…We try to obtain this new polymorphic form Phase-II by slow solvent evaporation method [9,10]. Organic solvents such as N,N-dimethylformamide C 3 H 7 NO (DMF), dimethylsulfoxide C 2 H 6 SO (DMSO) and N,N-dimethylacetamide C 3 H 9 NO (DMA) were selected because they are known to form supramolecular assemblies in a variety of geometrical arrangements on their own or in combination with other molecules.…”

Section: Introductionmentioning

confidence: 99%

Crystal structure of the biclotymol–N,N-dimethylacetamide solvate 1:1: experimental and theoretical conformational analysis of biclotymol molecule

Nicolaı̈

Mahé

2010

Struct Chem

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The crystal structure of the N,N-dimethylacetamide-biclotymol 1:1 solvate has been determined at room temperature by X-ray single-crystal diffraction. The molecular geometry of the biclotymol molecule is compared to the geometries observed in the N,N-dimethylformamide and dimethylsulfoxide solvates, and in the unsolvated form Phase-I. Rotational energy profile of the isolated molecule was obtained by semi-empirical AM1 calculations with respect to two selected torsional angles, which were rotated from 0°to 360°by steps of 10°. Not only, we find the two conformations experimentally observed, but also the conformation proposed by simple force fields calculations 30 years ago. Moreover, we propose three additional possible conformations that may offer potential candidates for the structure biclotymol Phase-II, which remains to be solved.

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“…These phenomena have been the focus of monographs devoted to polymorphism and solvatomorphism, [1][2][3][4] and the ongoing interest in the field has been documented in the preceding annual reviews of this series. [5][6][7][8][9] The present review will summarize works that have been published during 2009, with the papers and patents cited in the present review being drawn primarily from the major physical, crystallographic,…”

Section: Introductionmentioning

confidence: 99%