Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease

Chen, Hong; Yu, Ming; Li, Ming; Zhao, Ruie; Zhu, Qihan; Zhou, Wenrui; Ming, Lu; Lu, Yunxia; Zheng, Tao; Jiang, Jiamei; Zhao, Wenxue; Xiang, Kun–san; Jia, Weiping; Liu, Limei

doi:10.1007/s11010-011-1160-3

Cited by 77 publications

(59 citation statements)

References 30 publications

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“…There were significant negative relationships between MDA and HCV-RNA levels with Zn contents in erythrocytes and whole blood. Se deficiency has been observed to be inversely associated with HCV-RNA loads, the severity of hepatic fibrosis, and IR in HCV-infected patients (Ko et al, 2005b;Himoto et al, 2011;Chen et al, 2012). On the other hand, serum, plasma, and erythrocyte levels of Fe and Cu were significantly higher in hepatitis C patients.…”

Section: Alterations In Enzymatic Antioxidants and Cofactorsmentioning

confidence: 99%

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

Guo¹,

Chen²

2012

Antioxidant Enzyme

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Section: Alterations In Enzymatic Antioxidants and Cofactorsmentioning

confidence: 99%

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

Guo¹,

Chen²

2012

Antioxidant Enzyme

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“…Одним из наиболее важных звеньев АОС является фермент каталаза, ген САТ которой локализован на 11-й хромосоме [14]. В нашем исследовании объектом изучения был выбран наименее описанный полиморфизм Т21А rs 17880664 гена САТ, при котором происходит замена азотисто-го основания тимина на аргинин в позиции 21 ну-клеотида, изученный в контексте предрасположен-ности к развитию некоторых соматических заболе-ваний [15,16].…”

Section: результаты и обсуждениеunclassified

Analysis of genes polymorphism of catecholamines metabolism and antioxidant system in women with recurrent miscarriage

Макаров¹,

Morozova²,

Salnikova³

et al. 2015

Probl. reprod.

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“…There is evidence that elevated plasma SOD levels can decrease the damage in diabetics [19,20]. Additionally, GPx can catalyze lipid hydroperoxides to lipid alcohols in a reaction that utilizes GSH as a co-substrate to reduce the effects of oxygen derived free radicals [21].…”

Section: Introductionmentioning

confidence: 99%

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Xie

Zeng

et al. 2017

Open Life Sciences

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Abstract:We investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities.

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Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease

Cited by 77 publications

References 30 publications

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

Analysis of genes polymorphism of catecholamines metabolism and antioxidant system in women with recurrent miscarriage

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

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