Polymorphic Variants of the PDGFRB Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study

Abstract

Background: Differences in response to PRP (platelet-rich plasma) therapy may be linked to the variability of growth factors and their receptor’s genes. Considering that, we checked whether the platelet-derived growth factor receptor beta gene (PDGFRB) single nucleotide polymorphisms (SNPs) affect the effectiveness of PRP therapy in treating tennis elbow patients. Methods: The treatment efficacy was analyzed over time (2, 4, 8, 12, 24, 52, and 104 weeks after PRP injection) on 107 patients (132 elbows) using PROMs (patient-reported outcome measures), namely VAS (Visual Analog Scale), QDASH (quick version of Disabilities of the Arm, Shoulder, and Hand) and PRTEE (Patient-Rated Tennis Elbow Evaluation). Five polymorphisms of the PDGFRB gene (rs4324662, rs758588, rs3828610, rs3756311, and rs3756312) were genotyped. Results: The CC (rs3828610) and GG (rs3756311 and rs3756312) genotypes had a particularly strong impact on the effectiveness of the therapy, as measured by the values of PROMs, both in additive as well as dominant/recessive models. These homozygotes were also characterized by significantly higher values of MPV (mean platelet volume). Conclusions: The PDGFRB gene SNPs affect the effectiveness of PRP therapy in treating tennis elbow patients and it may result from the differentiated metabolic activity of platelets in particular genotype variants.

The Role of Platelet-Rich Plasma on the Chondrogenic and Osteogenic Differentiation of Human Amniotic-Fluid-Derived Stem Cells

“…In recent decades, the use of PRP has gained popularity in the field of tissue engineering because of its anti-inflammatory and analgesic properties, as well as its capacity to induce neo-angiogenesis, tissue formation, and remodeling by influencing stem-cell migration, proliferation, and differentiation [ 14 ]. Because of these properties, the clinical use of PRP in the orthopedic field has increased more and more, with it finding an application with encouraging results in the most common orthopedic pathologies, such as muscle lesions, acute and chronic tendinitis, mild osteoarthritis, and osteochondral lesions [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

“…Because of all these characteristics, PRP has found wide application in clinical practice, useable as local infiltration in many orthopedic diseases, such as as mild osteoarthritis, acute and chronic tendinitis, and plantar fasciitis, as well as in pathologies that are not strictly orthopedic, such as the treatment of chronic wounds and diabetic ulcers, and it has even found application in other fields of medicine, such as plastic surgery and medical esthetics [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

“…Single nucleotide polymorphisms were also investigated as possible factors for various responses of patients in the tissue healing process. Researchers Szyluk et al demonstrated that polymorphic variants of PDGFRB gene, which encodes the PDGFRB receptor involved in the development of blood vessels and in the bone healing process, influence the effectiveness of PVRP treatment of tennis elbow [ 68 ].…”

Platelet-Rich Plasma and Acellular Dermal Matrix in the Surgical Treatment of Hidradenitis Suppurativa: A Comparative Retrospective Study

“…Numerous papers prove the wide application of PRP in tissue regeneration in various fields, such as dentistry, orthopedics, maxillofacial surgery, sports medicine, ophthalmology, and peripheral nerve regeneration. Currently, the most extensive research is being conducted on the use of PRP for tissue regeneration and repair and the prevention of infection [ 16 , 17 ].…”