Polymorphic Changes of Thiamine Hydrochloride During Granulation and Tableting

Wöstheinrich, Karin; Schmidt, Peter

doi:10.1081/ddc-100105172

Cited by 29 publications

(12 citation statements)

References 7 publications

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“…DSC thermograms of processed and original vitamin B 1 powders included two endothermic peaks: the first beginning at about 40°C was attributed to moisture elimination and the second above 248°C, corresponding to melting of thiamine hydrochloride. No hydrate formation during powder processing was observed due to the nonappearance of the peak, corresponding to the elimination of water of crystallization in the region between 140°C and 185°C (21). Minor dissimilarities in the molar enthalpy of fusion confirmed the absence of significant changes in crystallinity after aqueous mist treatment.…”

Section: Solid State Propertiesmentioning

confidence: 59%

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

et al. 2009

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Abstract. The goal of the present study was to design a new technique to modify particle surface properties and, through that, to improve flowability of poorly flowing drug thiamine hydrochloride and pharmaceutical sugar lactose monohydrate of two different grades. The powdered particles were supplied by a vibratory feeder and exposed to an instantaneous effect of water mist generated from an ultrasound nebulizer. The processed and original powders were evaluated with respect to morphology (scanning electron microscopy, atomic force microscopy, and spatial filtering technique), flow, and solid state properties. It was found that rapid exposition of pharmaceutical materials by water mist resulted in the improvement of powder technical properties. The evident changes in flowability of coarser lactose were obviously due to smoothing of particle surface and decreasing in the level of fines with very slight increment in particle size. The changes in thiamine powder flow were mainly due to narrowing in particle size distribution where the tendency for better flow of finer lactose was related to surface and size modifications. The aqueous mist application did not cause any alteration of the crystal structures of the studied materials. The proposed water mist treatment technique appears to be a robust, rapid, and promising tool for the improvement of the technological properties of pharmaceutical powders.

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Section: Solid State Propertiesmentioning

confidence: 59%

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

et al. 2009

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“…Formation of cocrystals and their subsequent agglomeration in a single step saves at least four operations involved in conventional size enlargement processes (granulation) for pharmaceuticals. Another advantage is the prevention of polymorphic changes, to which drugs can be susceptible during these unit operations (31).…”

Section: Resultsmentioning

confidence: 99%

Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion

et al. 2010

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“…Wostheinrich et al have reported that tabletting of thiamine hydrochloride could cause its conversion to monohydrate. 23 For the hydrates having relatively high stability, compression usually has no effect on its solid-state form. Diclofenac sodium tetrahydrate remained as hydrate after compressing at 443 MPa for 1 h, and the same was found for cefdinir monohydrate after compression at 135 MPa.…”

Section: Unit Operations Involving Watermentioning

confidence: 99%

Perspective on Water of Crystallization Affecting the Functionality of Pharmaceuticals

Tian

Rantanen

2011

Food Biophysics

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Water can be incorporated into crystalline lattice of organic molecules in several ways and thus forms systems with different molecular packing characteristics. This review outlines a general classification of hydrates and explains why it is of high relevance for pharmaceutical researchers to investigate water of crystallization and hydrate systems. The different manufacturing steps related to the final drug product are also briefly discussed with an emphasis on the role of water and possible solid-state transformations related to hydrates. Application of spectroscopic techniques in characterizing water of crystallization and the effect of water on the drug and formulation stability are presented. Moreover, the role of water on the in vitro drug dissolution behavior is reviewed where an example is shown to illustrate the recent development on correlating solid state of the drug, for instance, hydrate formation, to the dissolution profile of the product, to achieve a better understanding of the dissolution process.

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Polymorphic Changes of Thiamine Hydrochloride During Granulation and Tableting

Cited by 29 publications

References 7 publications

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist

Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion

Perspective on Water of Crystallization Affecting the Functionality of Pharmaceuticals

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