Polymicrobial wound infections: Pathophysiology and current therapeutic approaches

Berteșteanu, Șerban; Triaridis, Stefanos; Stanković, Milan; Lazăr, Veronica; Chifiriuc, Mariana Carmen; Vlad, Mihaela; Grigore, Raluca

doi:10.1016/j.ijpharm.2013.12.012

Cited by 90 publications

(78 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetite nanoparticles with anti-pathogenic properties attract the interest of researchers in the last 5 years [19,20,21,22,23,24,25,26,27]. A series of papers reports two novel approaches in addition to classical applications.…”

Section: Resultsmentioning

confidence: 99%

MAPLE fabrication of thin films based on kanamycin functionalized magnetite nanoparticles with anti-pathogenic properties

Grumezescu

Andronescu

Holban

et al. 2015

Applied Surface Science

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

MAPLE fabrication of thin films based on kanamycin functionalized magnetite nanoparticles with anti-pathogenic properties

Grumezescu

Andronescu

Holban

et al. 2015

Applied Surface Science

Self Cite

View full text Add to dashboard Cite

“…Interestingly, a number of virulence factors in S. aureus were enhanced by C. albicans. 25 Burns caused by both P. aeruginosa and S. aureus have resulted in a chronic non-healing wound in which such co-infection have shown that the P. aeruginosa limits S. aureus growth. 26 The majority of previous studies on polymicrobial burn infections have documented the pathogen-infection interaction, but often ignored the host microbiota.…”

Section: Introductionmentioning

confidence: 99%

Synthesized zinc peroxide nanoparticles (ZnO<sub>2</sub>-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds

Ali¹,

Morsy²,

El-Zawawy³

et al. 2017

IJN

119

View full text Add to dashboard Cite

Increasing of multidrug resistance (MDR) remains an intractable challenge for burn patients. Innovative nanomaterials are also in high demand for the development of new antimicrobial biomaterials that inevitably have opened new therapeutic horizons in medical approaches and lead to many efforts for synthesizing new metal oxide nanoparticles (NPs) for better control of the MDR associated with the polymicrobial burn wounds. Recently, it seems that metal oxides can truly be considered as highly efficient inorganic agents with antimicrobial properties. In this study, zinc peroxide NPs (ZnO 2 -NPs) were synthesized using the co-precipitation method. Synthesized ZnO 2 -NPs were characterized by X-ray diffraction, Fourier transformed infrared, transmission electron microscopy, thermogravimetric analysis, differential scanning calorimetry, and ultraviolet-visible spectroscopy. The characterization techniques revealed synthesis of the pure phase of non-agglomerated ZnO 2 -NPs having sizes in the range of 15–25 nm with a transition temperature of 211°C. Antimicrobial activity of ZnO 2 -NPs was determined against MDR Pseudomonas aeruginosa (PA) and Aspergillus niger (AN) strains isolated from burn wound infections. Both strains, PA6 and AN4, were found to be more susceptible strains to ZnO 2 -NPs. In addition, a significant decrease in elastase and keratinase activities was recorded with increased concentrations of ZnO 2 -NPs until 200 µg/mL. ZnO 2 -NPs revealed a significant anti-inflammatory activity against PA6 and AN4 strains as demonstrated by membrane stabilization, albumin denaturation, and proteinase inhibition. Moreover, the results of in vivo histopathology assessment confirmed the potential role of ZnO 2 -NPs in the improvement of skin wound healing in the experimental animal models. Clearly, the synthesized ZnO 2 -NPs have demonstrated a competitive capability as antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory candidates, suggesting that the ZnO 2 -NPs are promising metal oxides that are potentially valued for biomedical applications.

show abstract

“…In addition, the role of anaerobic species in wound infection is becoming increasingly recognized [17]. These fastidious species present challenges in their culture and inoculation due to sensitivity to atmospheric oxygen, but due to their role in chronic wounds and multi-pathogen infection, infected animal models are more frequently incorporating anaerobic species [18]. Out of these three general classes (gram positive, gram negative, and anaerobic), the specific organism is chosen based on prevalence in human disease.…”

Section: 0 Considerations In Model Selectionmentioning

confidence: 99%

“…While the majority of animal models of infected tissue defects challenge wounds with one pathogen species at a time, human chronic wounds such as diabetic ulcers most frequently feature polymicrobial communities [18, 33]. In addition, multiple species have been demonstrated to show synergistic effects and alter bacterial phenotype in animal wound models [34].…”

Section: 0 Considerations In Model Selectionmentioning

confidence: 99%

Infected animal models for tissue engineering

Tatara

Shah

Livingston

et al. 2015

Methods

View full text Add to dashboard Cite

Infection is one of the most common complications associated with medical interventions and implants. As tissue engineering strategies to replace missing or damaged tissue advance, the focus on prevention and treatment of concomitant infection has also begun to emerge as an important area of research. Because the in vivo environment is a complex interaction between host tissue, implanted materials, and native immune system that cannot be replicated in vitro, animal models of infection are integral in evaluating the safety and efficacy of experimental treatments for infection. In this review, considerations for selecting an animal model, established models of infection, and areas that require further model development are discussed with regard to cutaneous, fascial, and orthopedic infections.

show abstract

Polymicrobial wound infections: Pathophysiology and current therapeutic approaches

Cited by 90 publications

References 132 publications

MAPLE fabrication of thin films based on kanamycin functionalized magnetite nanoparticles with anti-pathogenic properties

MAPLE fabrication of thin films based on kanamycin functionalized magnetite nanoparticles with anti-pathogenic properties

Synthesized zinc peroxide nanoparticles (ZnO<sub>2</sub>-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds

Infected animal models for tissue engineering

Contact Info

Product

Resources

About