Polymicrobial bacteremia in critically ill patients

Rello, Jordi; Quintana, E.; Mirelis, Beatriz; Gurguí, M.; Net, A.; Prats, Guillem

doi:10.1007/bf01709273

Cited by 46 publications

(36 citation statements)

References 24 publications

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“…In our study, the prevalence of polymicrobial bacteremia was 11.6% (10/86), which was somewhat higher than other recent studies, which evaluated the BC-GN assay (5-7.2%) (Dodémont et al, 2014;Rello et al, 1993;Sullivan et al, 2014;Tojo et al, 2014). Among the 10 patients with polymicrobial bacteremia, 3 patients had hematologic malignancies, and 4 patients had gastrointestinal cancers.…”

Section: Discussioncontrasting

confidence: 69%

Rapid detection of Gram-negative bacteria and their drug resistance genes from positive blood cultures using an automated microarray assay

Han

Park

Kim

et al. 2015

Diagnostic Microbiology and Infectious Disease

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Section: Discussioncontrasting

confidence: 69%

Rapid detection of Gram-negative bacteria and their drug resistance genes from positive blood cultures using an automated microarray assay

Han

Park

Kim

et al. 2015

Diagnostic Microbiology and Infectious Disease

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“…In addition, the result of the simulated multiple Acinetobacter species infections suggested that multiple species could be discriminated by the ASPE assay despite being present in the mixture at different ratios. Polymicrobial bacteremia was identified in 5 to 22% of bacteremia cases (25,33), and blood cultures may be inefficient in detecting polymicrobial bacteremia (27). Therefore, these data suggested that the ASPE assay is useful for clinical application.…”

Section: Discussionmentioning

confidence: 99%

Application of a Microsphere-Based Array for Rapid Identification of Acinetobacter spp. with Distinct Antimicrobial Susceptibilities

et al. 2008

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Acinetobacter spp. have emerged as important nosocomial and multidrug-resistant pathogens in the last decade. A. calcoaceticus, A. baumannii, Acinetobacter genospecies 3, and Acinetobacter genospecies 13TU are genetically closely related and are referred to as the A. calcoaceticus-A. baumannii complex (ACB complex). Distinct Acinetobacter spp. may be associated with differences in antimicrobial susceptibility, so it is important to identify Acinetobacter spp. at the species level. We developed a microsphere-based array that combines an allele-specific primer extension assay and microsphere hybridization for the identification of Acinetobacter spp. This assay can discriminate the 13 different Acinetobacter spp. in less than 8.5 h, and it has high specificity without causing cross-reactivity with 14 other common nosocomial bacterial species. The sensitivity of this assay was 100 A. baumannii cells per ml of blood, and it could discriminate multiple species in various mixture ratios. The developed assay could differentiate clinical Acinetobacter spp. isolates with a 90% identification rate. The antimicrobial susceptibility test showed that A. baumannii isolates were resistant to most antimicrobial agents other than imipenem, while the genospecies 3 and 13TU isolates were more susceptible to most antimicrobial agents, especially ciprofloxacin and ampicillinsulbactam. These results supported the idea that this assay possibly could be applied to clinical samples and provide accurate species identification, which might be helpful for clinicians when they are treating infections caused by Acinetobacter spp.

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“…6,7 Patients with polymicrobial bacteremia usually have higher mortality rates than patients with monomicrobial bacteremia, 1,5 but their increased mortality rates may be confounded by their high rates of comorbid conditions. 8 Staphylococcus aureus is a frequent cause of bacteremia, and S. aureus bacteremia (SAB) is associated with high rates of life threatening complications, with documented associated mortality rates of 20e40%.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance and outcome of polymicrobial Staphylococcus aureus bacteremia

Park¹,

Park²,

Bang³

et al. 2012

Journal of Infection

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Polymicrobial bacteremia in critically ill patients

Abstract: We suggest catheter replacement in patients who develop PMB and improving techniques of catheter maintenance in order to reduce its incidence.

Cited by 46 publications

References 24 publications

Rapid detection of Gram-negative bacteria and their drug resistance genes from positive blood cultures using an automated microarray assay

Rapid detection of Gram-negative bacteria and their drug resistance genes from positive blood cultures using an automated microarray assay

Application of a Microsphere-Based Array for Rapid Identification of Acinetobacter spp. with Distinct Antimicrobial Susceptibilities

Clinical significance and outcome of polymicrobial Staphylococcus aureus bacteremia

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