Polymethylmethacrylate-based bone cement modified with hydroxyapatite

Vallo, Claudia Ines; Montemartini, Pablo E.; Fanovich, María Alejandra; López, José Manuel; Cuadrado, T. R.

doi:10.1002/(sici)1097-4636(1999)48:2<150::aid-jbm9>3.0.co;2-d

Cited by 126 publications

(48 citation statements)

References 27 publications

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“…For example, the polymer matrix may be nonresorbable and non-injectable (e.g., thermoplastics such as PAEK, [40][41][42][43] UHMWPE, 44 and HDPE 1-6 ), nonresorbable and injectable (e.g., acrylics such as PMMA [45][46][47][48][49][50][51][52] and bis-GMA/TEG-DMA 52-57 ), bioresorbable and non-injectable (e.g., collagen [58][59][60][61] or poly--hydroxy esters such as PLLA and PLGA 62-68 ), or bioresorbable and injectable (e.g., collagen, calcium phosphate cements [68][69][70][71] and various hydrogels [72][73][74][75]. (Collagen may function as either noninjectable or injectable depending on whether it has been cross-linked prior to implantation.…”

Section: The Polymer Matrixmentioning

confidence: 99%

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Hydroxyapatite-reinforced polymer biocomposites for synthetic bone substitutes

Roeder

Converse

Kane

et al. 2008

JOM

124

100

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Overview Biological Materials ScienceHydroxyapatite (HA)-reinforced polymer biocomposites offer a robust system to engineer synthetic bone substitutes with tailored mechanical, biological, and surgical functions. The basic design rationale has been to reinforce a tough, biocompatible polymer matrix with a bioactive HA filler. A large number of studies have investigated modifications to the biocomposite structure and composition, aimed at improving the mechanical properties, often through modified or novel processing methods. In this article, the effects of the polymer composition and molecular orientation; the HA/polymer interface; and the HA-reinforcement content, morphology, preferred orientation, and size are reviewed with respect to mechanical properties, drawing frequent comparisons between various HA-reinforced polymer composites and bone tissue.

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Section: The Polymer Matrixmentioning

confidence: 99%

“…Finally, note that an Ashby diagram like that shown in Figure 2 could not be plotted for HA-reinforced polymers due to the small number of fracture toughness measurements. 47,51,55,81,82 This paucity of data is somewhat surprising given the importance of fracture toughness to the material performance.…”

Section: The Polymer Matrixmentioning

confidence: 99%

Hydroxyapatite-reinforced polymer biocomposites for synthetic bone substitutes

Roeder

Converse

Kane

et al. 2008

JOM

124

100

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“…Absence of fibrous tissue, necrotic tissue and immune cells apart from complete integration of the repaired bone with old bone makes it desirable bone filler. The other injectable graft material including cements, used for surgeries generally set with exothermic reactions and result in necrosis of surrounding tissue (Hong et al 1991; Vallo et al 1999). The implant site at times needs to be contoured with burr whereas simple hand contouring is sufficient.…”

Section: Resultsmentioning

confidence: 99%

“…Among polymers, methyl methacrylate is quite commonly used though it lacks properties of osteointegration and could result in necrosis and infection. These polymer-based materials also suffer from exothermic setting reactions (Vallo et al 1999). Calcium phosphate (Ca–P) cements were introduced by Brown and Chow 1983 and these self-curing cements proved safe as they are made of mineral closer to natural bone matrix and show osteocompatibility and integration.…”

Section: Introductionmentioning

confidence: 99%

Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions

et al. 2014

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Pressing need for utilization of injectables/fillers in various forms of orthopaedic treatments/surgeries commands an equal demand for better graft material. Injectable bone graft material based on biomimetically synthesized nanohydroxyapatite was developed and subjected to ball milling for different times; three materials thus produced were evaluated for their biological properties. The three composites tested were found to have some difference in proliferation and differentiation on mesenchymal stem cells in cultures. In vivo studies were performed by implanting the graft materials with or without cells in the bone drill hole injury created in the femur of Wistar rats. Our studies show that the composites lead to well-healed injury site with normal histology without inflammation or fibrous tissue formation and bone deformity. This material needs to be tested on large animals for further ascertaining its applicability in clinical use.

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“…Additionally, bone tissue scaffolds frequently also contain biocompatible polymers to emulate bone-like chemical and mechanical properties [6]. Historically, synthetic polymers [7] such as polyethylene oxide (PEO) [8], polymethylmethacrylate [9], polyethylene terephthalate [10], poly-ε-caprolactone (PCL) [11] and polylactic- co -glycolic acid [12] have been of interest, although collagen [13], alginate [14], soy/gelatin [15], fibrin [16], cellulose-based [17], chitin [18] and chitosan [19] biopolymers are now gaining more attention due to their versatile chemistry, resorbability, bioactivity, water-uptake ability, improved biocompatibility and non-toxicity.…”

Section: Introductionmentioning

confidence: 99%

Osteoblast biocompatibility of premineralized, hexamethylene-1,6-diaminocarboxysulfonate crosslinked chitosan fibers

Kiechel

Beringer

Donius

et al. 2015

J. Biomed. Mater. Res.

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Biopolymer-ceramic composites are thought to be particularly promising materials for bone tissue engineering as they more closely mimic natural bone. Here, we demonstrate the fabrication by electrospinning of fibrous chitosan-hydroxyapatite composite scaffolds with low (1 wt%) and high (10 wt%) mineral contents. Scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS) and unidirectional tensile testing were performed to determine fiber surface morphology, elemental composition, and tensile Young’s modulus (E) and ultimate tensile strength (σUTS), respectively. EDS scans of the scaffolds indicated that the fibers, crosslinked with either hexamethylene-1,6-diaminocarboxysulfonate (HDACS) or genipin, have a crystalline hydroxyapatite mineral content at 10 wt% additive. Moreover, FESEM micrographs showed that all electrospun fibers have diameters (122 – 249 nm), which fall within the range of those of fibrous collagen found in the extracellular matrix of bone. Young’s modulus and ultimate tensile strength of the various crosslinked composite compositions were in the range of 116 – 329 MPa and 2 – 15 MPa, respectively. Osteocytes seeded onto the mineralized fibers were able to demonstrate good biocompatibility enhancing the potential use for this material in future bone tissue engineering applications.

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Polymethylmethacrylate-based bone cement modified with hydroxyapatite

Cited by 126 publications

References 27 publications

Hydroxyapatite-reinforced polymer biocomposites for synthetic bone substitutes

Hydroxyapatite-reinforced polymer biocomposites for synthetic bone substitutes

Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions

Osteoblast biocompatibility of premineralized, hexamethylene-1,6-diaminocarboxysulfonate crosslinked chitosan fibers

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