Polymethine in der Pharmazie

Görlitzer, K.

doi:10.1002/pauz.19760050503

Cited by 27 publications

(43 citation statements)

References 3 publications

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“…Pyrimidine derivatives form a component in a number of useful drugs and are associated with many biological and therapeutical activities [2]. Pyrimidine derivatives have been reported as anti-microbial [3], analgesic, anti-viral, anti-inflammatory [4], anti-HIV [5], anti-tubercular [6], anti-tumour [7], anti-malarial [8], cardiovascular [9] agents. Pyrimidine derivatives have been found to exhibit cytostatic [10][11][12], immune modulating [13,14] and antibacterial properties [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Arulkumaran¹,

Sundararajan²,

Manikandan³

et al. 2014

ILCPA

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A series of 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamide compounds have been synthesized from various substituted dithioacetal and guanidine. The purities of these compounds were checked by their physical constants, UV, IR, NMR and MASS spectral data. The IR and 1 HNMR spectral data of these compounds have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed.

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Section: Introductionmentioning

confidence: 99%

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Arulkumaran¹,

Sundararajan²,

Manikandan³

et al. 2014

ILCPA

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“…IR spectra were recorded on a Perkin-Elmer BX serried FTIR 5000 spectrometer using KBr pellet. 1 H NMR and 13 C NMR spectra were recorded at room temperature on a Varian spectrometer at 300 and 100 MHz operating frequency using tetramethylsilane (TMS) as an internal standard. Mass spectra were recorded on a VG-Micromass 7070H spectrometer operating at 70 eV.…”

Section: Methodsmentioning

confidence: 99%

“…Consequently, chemists still enthusiastically pursue the syntheses and activity evaluation of thiazolidine derivatives [6]. Nitrogen containing heterocyclic ring such as pyrimidine is a promising structural moiety for drug design and are associated with many biological and therapeutical activities such as antimicrobial [7], analgesic, antiviral, antiinflammatory [8], anti-HIV [9], antitubercular [10], antitumour [11], antineoplastic [12], antimalarial [13], diuretic [14], cardiovascular [15] agents. On the other hand thiazolo-pyrimidines are important class of compounds with wide range of biological activity [16].…”

Section: Introductionmentioning

confidence: 99%

Novel Pyrimidine Associated Thiazolidines: Design, Synthesis, Characterization and Evaluation as Antibacterial Agents

Maddireddi¹,

Parimi²,

Reddy³

et al. 2017

Asian J. Chem.

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Several novel pyrimidine associated thiazolidines (5a-f) have been synthesized by using 6-trifluoromethyl-pyrimidine-4-ol (1) as starting material and by participating (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid ethyl ester (2) (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid hydrazide (3) and (6-trifluoromethyl-pyrimidine-4-yloxy)acetic acid benzylidene-hydrazides (4a-f) as intermediates through substitution, condensation and cyclization. The chemical structures of all the newly synthesized compounds were confirmed by IR, 1 H and 13 C NMR, mass spectral studies and elemental analysis. Further, the synthesized products were screened for their antibacterial activity and the zone of inhibition was measured.

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“…It is reported that many heterocyclic compounds bearing benzofuro[3,2-b]pyridine moiety have anti-allergic, 5 endothelin receptor-antagonists, 6 anti-inflammatory, anti-microbial, analgesic activity, 7 and antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

2,4-Diaryl Benzofuro[3,2-b]pyridine Derivatives: Design, Synthesis, and Evaluation of Topoisomerase Inhibitory Activity and Cytotoxicity

Thapa¹,

Jahng²,

Park³

et al. 2013

Bulletin of the Korean Chemical Society

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Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2-or 3-furyl, 2-or 3-thienyl, and 2-pyridyl were substituted at 2-or 4-position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2-or 4-position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 µM.

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Polymethine in der Pharmazie

Cited by 27 publications

References 3 publications

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Novel Pyrimidine Associated Thiazolidines: Design, Synthesis, Characterization and Evaluation as Antibacterial Agents

2,4-Diaryl Benzofuro[3,2-b]pyridine Derivatives: Design, Synthesis, and Evaluation of Topoisomerase Inhibitory Activity and Cytotoxicity

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