The Mollendo-Camana Block (MCB) is a 50 · 150 km Precambrian inlier of the Andean belt that outcrops along the Pacific coast of southern Peru. It consists of stromatic migmatites of Paleoproterozoic heritage intensely metamorphosed during the Grenville event (c. 1 Ga; U-Pb and U-Th-Pb ages on zircon and monazite). In the migmatites, aluminous mesosomes (FMAS) and quartzofeldspathic leucosomes (KFMASH), contain various amounts of K-feldspar (Kfs), orthopyroxene (X Mg Opx ¼ 0.86), plagioclase (Pl), sillimanite (Sil; exceptionally kyanite, Ky) ilmenite (Ilm), magnetite (Mag), quartz (Qtz), and minor amounts of garnet (X Mg Grt ¼ 0.60), sapphirine (X Mg Spr ¼ 0.87), cordierite (X Mg Crd ¼ 0.92) and biotite (X Mg Bt ¼ 0.83). The ubiquitous peak mineral assemblage is Opx-Sil-Kfs-Qtz-(± Grt) in most of the MCB, which, together with the high Al content of orthopyroxene (10% Al 2 O 3 ) and the local coexistence of sapphirine-quartz, attest to regional UHT metamorphism (> 900°C) at pressures in excess of 1.0 GPa. Fluid-absent melting of biotite is responsible for the massive production of orthopyroxene that proceeded until exhaustion of biotite (and most of the garnet) in the southern part of the MCB (Mollendo-Cocachacra areas). In this area, a first stage of decompression from 1.1-1.2 to 0.8-0.9 GPa at temperatures in excess of 950°C, is marked by the breakdown of Sil-Opx to Spr-Opx-Crd assemblages according to several bivariant FMAS reactions. High-T decompression is also shown by Mg-rich garnet being replaced by Crd-Spr-and Crd-Opxbearing symplectites, and reacting with quartz to produce low-Al-Opx-Sil symplectites in quartz-rich migmatites. Neither osumilite nor spinel-quartz assemblages being formed, isobaric cooling at about 0.9 GPa probably followed the initial decompression and proceeded with massive precipitation of melts towards the (Os) invariant point, as demonstrated by Bt-Qtz-(± pl) symplectites in quartz-rich migmatites (melt + Opx + Sil ¼ Bt + Grt + Kfs + Qtz). Finally, Opx rims around secondary biotite attest to late fluid-absent melting, compatible with a second stage of decompression below 900°C. The two stages of decompression are interpreted as due to rapid tectonic denudation whereas the regional extent of UHT metamorphism in the area, probably results from large-scale penetration of hot asthenospheric mantle at the base of an over-thickened crust.