Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids

Tao, Xinfeng; Chen, Hui; Trépout, Sylvain; Cen, Jiayu; Ling, Jun; Li, Min-Hui

doi:10.1039/c9cc07501a

Cited by 23 publications

(20 citation statements)

References 22 publications

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“…Due to the absence of hydrogen bonding and stereogenic centers along the backbone ( Figure 1 ), polypeptoids exhibit good thermal processability and solubility in various organic solvents, as well as enhanced protease stability, in sharp contrast to polypeptides. These features make polypeptoid a potential candidate for a wide variety of biomedical and biotechnological applications, such as antifouling coatings [ 46 , 47 , 48 , 49 , 50 , 51 ], drug/gene delivery [ 52 , 53 , 54 , 55 ] and biosensing [ 56 , 57 , 58 ]. Recent developments in the controlled polymerization and solid-phase synthesis have enabled access to a variety of polypeptoids with tailorable chain length, N-substituent structures, sequence, and architecture [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ].…”

Section: Introductionmentioning

confidence: 99%

Solution Self-Assembly of Coil-Crystalline Diblock Copolypeptoids Bearing Alkyl Side Chains

Jiang

Zhang

2021

Polymers

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Polypeptoids, a class of synthetic peptidomimetic polymers, have attracted increasing attention due to their potential for biotechnological applications, such as drug/gene delivery, sensing and molecular recognition. Recent investigations on the solution self-assembly of amphiphilic block copolypeptoids highlighted their capability to form a variety of nanostructures with tailorable morphologies and functionalities. Here, we review our recent findings on the solutions self-assembly of coil-crystalline diblock copolypeptoids bearing alkyl side chains. We highlight the solution self-assembly pathways of these polypeptoid block copolymers and show how molecular packing and crystallization of these building blocks affect the self-assembly behavior, resulting in one-dimensional (1D), two-dimensional (2D) and multidimensional hierarchical polymeric nanostructures in solution.

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Section: Introductionmentioning

confidence: 99%

Solution Self-Assembly of Coil-Crystalline Diblock Copolypeptoids Bearing Alkyl Side Chains

Jiang

Zhang

2021

Polymers

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“…Self-assembly MRI contrast reagent Antimicrobial nanoparticles [82,9] Tyrosine-NTA (Tyr-NTA) vii (60 °C, tetramethylene sulfone) - [9] Sar-NTA i, ii, iii Hydrophilic block Stealth property, antifouling [4] NEG-NTA i, iii, iv Omnisoluble in solvents Mechanism research [83,84] NBG-NTA i, ii, iii, iv Temperature responsiveness Hydrophobic block [85][86][87] NAG-NTA i Self-assembly Postmodification [88] MeSPG-NTA i Self-assembly Oxidation responsiveness Ref.…”

Section: Polymerization Of Ntasmentioning

confidence: 99%

“…In aqueous solution, the amphiphilic block co-polypeptoids self-assembled into nanoparticles, which showed strong fluorescence emission. [88] Poly(N-3-(methylthio)propyl glycine)-b-polysarcosine (PMeSPG-b-PSar) synthesized from N-3-(methylthio)propyl glycine NTA (MeSPG-NTA) and Sar-NTA bore oxidation-responsive thioether groups, which could be oxidized to hydrophilic sulfoxides. The polymersomes based on PMeSPG-b-PSar and PMeSPG-b-PEG disassembled upon generation of reactive oxygen species triggered by light.…”

Section: Nta Monomers and Applicationmentioning

confidence: 99%

An Inspection into Multifarious Ways to Synthesize Poly(Amino Acid)s

Zheng

Bai

Tao

et al. 2021

Macromol. Rapid Commun.

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Poly(𝜶-amino acid)s (PAAs) attract growing attention due to their essential role in the application as biomaterials. To synthesize PAAs with desired structures and properties, scientists have developed various synthetic techniques with respective advantages. Here, different approaches to preparing PAAs are inspected. Basic features and recent progresses of these methods are summarized, including polymerizations of amino acid N-carboxyanhydrides (NCAs), amino acid N-thiocarboxyanhydrides (NTAs), and N-phenoxycarbonyl amino acids (NPCs), as well as other synthetic routes. NCA is the most classical monomer to prepare PAAs with high molecular weights (MWs). NTA polymerizations are promising alternative pathways to produce PAAs, which can tolerate nucleophiles including alcohols, mercaptans, carboxyl acids, and water. By various techniques including choosing appropriate solvents or using organic acids as promoters, NTAs polymerize to produce polypeptoids and polypeptides with narrow dispersities and designed MWs up to 55.0 and 57.0 kg mol −1 , respectively. NPC polymerizations are phosgene-free ways to synthesize polypeptides and polypeptoids. For the future prospects, detail investigations into polymerization mechanisms of NTA and NPC are expected. The synthesis of PAAs with designed topologies and assembly structures is another intriguing topic. The advantages and unsettled problems in various synthetic ways are discussed for readers to choose appropriate approaches for PAAs.

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“…Owing to their unique characteristics, a variety of AIE uorescent materials, including self-assembled nanomaterials, have been developed for extensive applications. [41][42][43][44][45][46][47] Here, the combination of AIE properties with polymer cubosomes and hexosomes creates original uorescent polymer materials for potential applications in theranostics and bioimaging. As far as we are aware, this is the rst report on AIE uorescent polymer cubosomes and hexosomes.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent polymer cubosomes and hexosomes with aggregation-induced emission

et al. 2021

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Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids

Abstract: Fluorescent and biocompatible polymersomes based on the amphiphilic block copolypeptoid P(TPE-NAG)-b-PSar are promising for bio-imaging and drug delivery applications.

Cited by 23 publications

References 22 publications

Solution Self-Assembly of Coil-Crystalline Diblock Copolypeptoids Bearing Alkyl Side Chains

Solution Self-Assembly of Coil-Crystalline Diblock Copolypeptoids Bearing Alkyl Side Chains

An Inspection into Multifarious Ways to Synthesize Poly(Amino Acid)s

Fluorescent polymer cubosomes and hexosomes with aggregation-induced emission

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